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Comparing Raman and Fluorescence lifetime spectroscopy from human atherosclerotic lesions using a bimodal probe

Title data

Dochow, Sebastian ; Fatakdawala, Hussain ; Phipps, Jennifer E. ; Ma, Dinglong ; Bocklitz, Thomas ; Schmitt, Michael ; Bishop, John W. ; Margulies, Kenneth B. ; Marcu, Laura ; Popp, Jürgen:
Comparing Raman and Fluorescence lifetime spectroscopy from human atherosclerotic lesions using a bimodal probe.
In: Journal of Biophotonics. Vol. 9 (2016) Issue 9 . - pp. 958-966.
ISSN 1864-0648
DOI: https://doi.org/10.1002/jbio.201500341

Official URL: Volltext

Abstract in another language

Fluorescence lifetime imaging (FLIm) and Raman spectroscopy are two promising methods to support morphological intravascular imaging techniques with chemical contrast. Both approaches are complementary and may also be used in combination with OCT/IVUS to add chemical specificity to these morphologic intravascular imaging modalities. In this contribution, both modalities were simultaneously acquired from two human coronary specimens using a bimodal probe. A previously trained SVM model was used to interpret the fluorescence lifetime data; integrated band intensities displayed in RGB false color images were used to interpret the Raman data. Both modalities demonstrate unique strengths and weaknesses and these will be discussed in comparison to histologic analyses from the two coronary arteries imaged.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: fluorescence lifetime; Raman spectroscopy,; bimodal; imaging; fiber probes; atherosclerosis
Institutions of the University: Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Computer Science > Lehrstuhl Künstliche Intelligenz in der Mikroskopie und Spektroskopie > Lehrstuhl Künstliche Intelligenz in der Mikroskopie und Spektroskopie - Univ.-Prof. Dr. Thomas Wilhelm Bocklitz
Result of work at the UBT: No
DDC Subjects: 500 Science > 530 Physics
Date Deposited: 19 May 2023 09:29
Last Modified: 19 May 2023 09:29
URI: https://eref.uni-bayreuth.de/id/eprint/76299