Antiparasitic activities of bimetallic N-heterocyclic carbene gold(I) complexes with ferrocene ligands : Relevance of chlorido and phosphino ligands

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Al Nasr, Ibrahim S. ; Weise, Markus ; Koko, Waleed S. ; Khan, Tariq A. ; Schobert, Rainer ; Biersack, Bernhard:
Antiparasitic activities of bimetallic N-heterocyclic carbene gold(I) complexes with ferrocene ligands : Relevance of chlorido and phosphino ligands.
In: Applied Organometallic Chemistry. Bd. 37 (2023) Heft 1 . - e6952.
ISSN 1099-0739
DOI: https://doi.org/10.1002/aoc.6952

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Abstract

Gold(I) complexes carrying imidazole-2-ylidene ligands and ferrocene substituents were prepared. Their activities against protozoal Leishmania major and Toxoplasma gondii parasites were analyzed. Certain gold(I) complexes with chlorido and 1,1′-bis(triphenylphosphino)ferrocene ligands revealed promising antiparasitic effects. The new chlorido complexes 5b and 5c showed high activities against T. gondii tachyzoites and L. major promastigotes while the new ferrocene-bridged bis-gold(I) complexes 8a and 8b were particularly active against L. major amastigotes and considerably selective as to toxicity results from Vero cells and macrophages.