Antifungal Activity of Natural Naphthoquinones and Anthraquinones against Madurella mycetomatis

Title data

Ma, Jingyi ; Todd, Matthew ; van de Sande, Wendy W. J. ; Biersack, Bernhard:
Antifungal Activity of Natural Naphthoquinones and Anthraquinones against Madurella mycetomatis.
In: Chemistry & Biodiversity. Vol. 20 (2023) Issue 5 . - e202300151.
ISSN 1612-1880
DOI: https://doi.org/10.1002/cbdv.202300151

Official URL:

Abstract in another language

Abstract Eumycetoma, the fungal form of the neglected tropical disease mycetoma, is a crippling infectious disease with low response rates to currently available antifungal drugs. In this study, a series of natural naphthoquinones and anthraquinones was evaluated for their activity against Madurella mycetomatis, which is the most common causative agent of eumycetoma. The metabolic activity of Madurella mycetomatis as well as the viability of Galleria mellonella larvae upon treatment with quinones was investigated. Several hydroxy-substituted naphthoquinones exhibited activity against Madurella mycetomatis. In particular, naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) was identified as a considerably active antifungal compound against Madurella mycetomatis (IC50=1.4 μM), while it showed reduced toxicity to Galleria mellonella larvae, which is a well-established in vivo invertebrate model for mycetoma drug studies.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Keywords:	antifungal; eumycetoma; naphthazarin; naphthoquinone; neglected tropical disease
Institutions of the University:	Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Organic Chemistry I - Univ.-Prof. Dr. Rainer Schobert Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT:	Yes
DDC Subjects:	500 Science > 540 Chemistry
Date Deposited:	28 Oct 2023 21:20
Last Modified:	15 Apr 2024 06:55
URI:	https://eref.uni-bayreuth.de/id/eprint/87430