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Straightforward synthesis of functionalized γ-Lactams using impure CO₂ stream as the carbon source

Title data

Qin, Yuman ; Cauwenbergh, Robin ; Pradhan, Suman ; Maiti, Rakesh ; Franck, Philippe ; Das, Shoubhik:
Straightforward synthesis of functionalized γ-Lactams using impure CO₂ stream as the carbon source.
In: Nature Communications. Vol. 14 (2023) . - 7604.
ISSN 2041-1723
DOI: https://doi.org/10.1038/s41467-023-43289-w

Abstract in another language

Direct utilization of CO2 into organic synthesis finds enormous applications to synthesize pharmaceuticals and fine chemicals. However, pure CO2 gas is essential to achieve these transformations, and the purification of CO2 is highly cost and energy intensive. Considering this, we describe a straightforward synthetic route for the synthesis of γ-lactams, a pivotal core structure of bioactive molecules, by using commercially available starting materials (alkenes and amines) and impure CO2 stream (exhaust gas is collected from the car) as the carbon source. This blueprint features a broad scope, excellent functional group compatibility and application to the late-stage transformation of existing pharmaceuticals and natural products to synthesize functionalized γ-lactams. We believe that our strategy will provide direct access to γ-lactams in a very sustainable way and will also enhance the Carbon Capture and Utilization (CCU) strategy.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Organic Chemistry I > Chair Organic Chemistry I - Univ.-Prof. Dr. Das Shoubhik
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 29 Nov 2023 06:38
Last Modified: 29 Nov 2023 08:13
URI: https://eref.uni-bayreuth.de/id/eprint/87889