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Nominally identical microplastic models differ greatly in their particle-cell interactions

Title data

Wieland, Simon ; Ramsperger, Anja ; Groß, Wolfgang ; Lehmann, Moritz ; Witzmann, Thomas ; Caspari, Anja ; Obst, Martin ; Gekle, Stephan ; Auernhammer, Günter K. ; Fery, Andreas ; Laforsch, Christian ; Kress, Holger:
Nominally identical microplastic models differ greatly in their particle-cell interactions.
In: Nature Communications. Vol. 15 (2024) . - 922.
ISSN 2041-1723
DOI: https://doi.org/10.1038/s41467-024-45281-4

Official URL: Volltext

Abstract in another language

Due to the abundance of microplastics in the environment, research about its possible adverse effects is increasing exponentially. Most studies investigating the effect of microplastics on cells still rely on commercially available polystyrene microspheres. However, the choice of these model microplastic particles can affect the outcome of the studies, as even nominally identical model microplastics may interact differently with cells due to different surface properties such as the surface charge. Here, we show that nominally identical polystyrene microspheres from eight different manufacturers significantly differ in their ζ-potential, which is the electrical potential of a particle in a medium at its slipping plane. The ζ-potential of the polystyrene particles is additionally altered after environmental exposure. We developed a microfluidic microscopy platform to demonstrate that the ζ-potential determines particle-cell adhesion strength. Furthermore, we find that due to this effect, the ζ-potential also strongly determines the internalization of the microplastic particles into cells. Therefore, the ζ-potential can act as a proxy of microplastic-cell interactions and may govern adverse effects reported in various organisms exposed to microplastics.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: Featured in Nature Communications Editor’s Highlights
Institutions of the University: Faculties
Faculties > Faculty of Mathematics, Physics und Computer Science
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics
Faculties > Faculty of Mathematics, Physics und Computer Science > Department of Physics > Professor Experimental Physics VI - Biologial Physics
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Ecology I
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Animal Ecology I > Chair Animal Ecology I - Univ.-Prof. Dr. Christian Laforsch
Research Institutions > Collaborative Research Centers, Research Unit > SFB 1357 - MIKROPLASTIK
Research Institutions
Research Institutions > Collaborative Research Centers, Research Unit
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 530 Physics
500 Science > 570 Life sciences, biology
Date Deposited: 01 Feb 2024 06:20
Last Modified: 07 Feb 2024 05:57
URI: https://eref.uni-bayreuth.de/id/eprint/88460