at Google ScholarTitle data
Gardey, Elena ; Sobotta, Fabian H. ; Quickert, Stefanie ; Bruns, Tony ; Brendel, Johannes C. ; Stallmach, Andreas:
ROS‐Sensitive Polymer Micelles for Selective Degradation in Primary Human Monocytes from Patients with Active IBD.
In: Macromolecular Bioscience.
Vol. 22
(2022)
Issue 4
.
- 2100482.
ISSN 1616-5195
DOI: https://doi.org/10.1002/mabi.202100482
Abstract in another language
Inflammatory bowel disease (IBD) is characterized by increased levels of reactive oxygen species (ROS) in inflamed areas of the gastrointestinal tract and in circulating immune cells, providing novel opportunities for targeted drug delivery. In the recent experiments, oxidation-responsive polymeric nanostructures selectively degrade in the presence of H2O2. Based on these results, it is hypothesized that such degradation process can be triggered in a similar way by the incubation with stimulated monocytes isolated from patients with IBD. A first indication is given by a significant correlation between excessive ROS and degradation of micelles in monocytes isolated from healthy individuals after phorbol 12-myristate 13-acetate (PMA) stimulation. But even if the ROS-sensitive micelles are incubated with nonstimulated monocytes from patients with active IBD, a spontaneous degradation is observed in contrast to micelles incubated with monocytes from healthy donors. The findings indicate that the thioether-based micelles are indeed promising for selective drug release in the presence of activated immune cells.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry I Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry I > Chair Macromolecular Chemistry I - Univ.-Prof. Dr. Johannes C. Brendel |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Date Deposited: | 20 Feb 2024 12:22 |
| Last Modified: | 02 May 2024 07:39 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/88581 |