at Google ScholarTitle data
Mansfield, Edward D. H. ; Hartlieb, Matthias ; Catrouillet, Sylvain ; Rho, Julia Y. ; Larnaudie, Sophie C. ; Rogers, Sarah E. ; Sanchis, Joaquin ; Brendel, Johannes C. ; Perrier, Sébastien:
Systematic study of the structural parameters affecting the self-assembly of cyclic peptide–poly(ethylene glycol) conjugates.
In: Soft Matter.
Vol. 14
(2018)
Issue 30
.
- pp. 6320-6326.
ISSN 1744-6848
DOI: https://doi.org/10.1039/C8SM01133H
Abstract in another language
Self-assembling cyclic peptides (CP) consisting of amino acids with alternating D- and L-chirality form nanotubes by hydrogen bonding, hydrophobic interactions, and π–π stacking in solution. These highly dynamic materials are emerging as promising supramolecular systems for a wide range of biomedical applications. Herein, we discuss how varying the polymer conformation (linear vs. brush), as well as the number of polymer arms per peptide unimer affects the self-assembly of PEGylated cyclic peptides in different solvents, using small angle neutron scattering. Using the derived information, strong correlations were drawn between the size of the aggregates, solvent polarity, and its ability to compete for hydrogen bonding interactions between the peptide unimers. Using these data, it could be possible to engineer cyclic peptide nanotubes of a controlled length.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry I Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry I > Chair Macromolecular Chemistry I - Univ.-Prof. Dr. Johannes C. Brendel |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Date Deposited: | 20 Feb 2024 06:58 |
| Last Modified: | 02 May 2024 07:39 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/88602 |