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Reichardt, Christian ; Monro, Susan ; Sobotta, Fabian H. ; Colón, Katsuya L. ; Sainuddin, Tariq ; Stephenson, Mat ; Sampson, Eric ; Roque III, John ; Yin, Huimin ; Brendel, Johannes C. ; Cameron, Colin G. ; McFarland, Sherri ; Dietzek, Benjamin:
Predictive Strength of Photophysical Measurements for in Vitro Photobiological Activity in a Series of Ru(II) Polypyridyl Complexes Derived from π-Extended Ligands.
In: Inorganic Chemistry.
Bd. 58
(2019)
Heft 5
.
- S. 3156-3166.
ISSN 1520-510X
DOI: https://doi.org/10.1021/acs.inorgchem.8b03223
Abstract
This study investigates the correlation between photocytotoxicity and the prolonged excited-state lifetimes exhibited by certain Ru(II) polypyridyl photosensitizers comprised of π-expansive ligands. The eight metal complexes selected for this study differ markedly in their triplet state configurations and lifetimes. Human melanoma SKMEL28 and human leukemia HL60 cells were used as in vitro models to test photocytotoxicity induced by the compounds when activated by either broadband visible or monochromatic red light. The photocytotoxicities of the metal complexes investigated varied over 2 orders of magnitude and were positively correlated with their excited-state lifetimes. The complexes with the longest excited-state lifetimes, contributed by low-lying 3IL states, were the most phototoxic toward cancer cells under all conditions.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie I |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Eingestellt am: | 20 Feb 2024 06:48 |
| Letzte Änderung: | 20 Feb 2024 06:48 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/88609 |