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Sobotta, Fabian H. ; Kuchenbrod, Maren T. ; Gruschwitz, Franka V. ; Festag, Grit ; Bellstedt, Peter ; Hoeppener, Stephanie ; Brendel, Johannes C.:
Tuneable Time Delay in the Burst Release from Oxidation‐Sensitive Polymersomes Made by PISA.
In: Angewandte Chemie International Edition.
Bd. 60
(2021)
Heft 46
.
- S. 24716-24723.
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.202108928
Abstract
Reactive polymersomes represent a versatile artificial cargo carrier system that can facilitate an immediate release in response to a specific stimulus. The herein presented oxidation-sensitive polymersomes feature a time-delayed release mechanism in an oxidative environment, which can be precisely adjusted by either tuning the membrane thickness or partial pre-oxidation. These polymeric vesicles are conveniently prepared by PISA allowing the straightforward and effective in situ encapsulation of cargo molecules, as shown for dyes and enzymes. Kinetic studies revealed a critical degree of oxidation causing the destabilization of the membrane, while no release of the cargo is observed beforehand. The encapsulation of glucose oxidase directly transforms these polymersomes into glucose-sensitive vesicles, as small molecules including sugars can passively penetrate their membrane. Considering the ease of preparation, these polymersomes represent a versatile platform for the confinement and burst release of cargo molecules after a precisely adjustable time span in the presence of specific triggers, such as H2O2 or glucose.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie I |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Eingestellt am: | 20 Feb 2024 06:38 |
| Letzte Änderung: | 20 Feb 2024 06:38 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/88620 |