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Wei, Peng ; Czaplewska, Justyna A. ; Wang, Limin ; Schubert, Stephanie ; Brendel, Johannes C. ; Schubert, Ulrich S.:
Straightforward Access to Glycosylated, Acid Sensitive Nanogels by Host–Guest Interactions with Sugar-Modified Pillar[5]arenes.
In: ACS Macro Letters.
Bd. 9
(2020)
Heft 4
.
- S. 540-545.
ISSN 2161-1653
DOI: https://doi.org/10.1021/acsmacrolett.0c00030
Abstract
The introduction of specific targeting units to polymer nanogels usually requires tedious chemical modifications, which limits flexibility in the design of combinatorial approaches. Here, we present a straightforward and versatile method to reversibly introduce various carbohydrate-based targeting units to a pH-sensitive nanogel via host–guest interactions. Glucose-, mannose-, or fructose-modified pillar[5]arenes can adaptably and conveniently be introduced to the surface of the nanogel. Binding studies between these nanogels and the lectin Concanavalin A revealed a high selectivity and strong interaction with only the mannose-modified nanogels. With the addition of other pillar[5]arenes, the interaction can be influenced proving a dynamic exchange of the targeting units. In comparison with common covalent modifications of polymer nanostructures, the presented combination of straightforward precipitation polymerization and supramolecular interactions promises convenient access to adaptable nanostructures for high-throughput screening of targeted delivery systems.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Lehrstuhl Makromolekulare Chemie I |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Eingestellt am: | 20 Feb 2024 08:28 |
| Letzte Änderung: | 20 Feb 2024 08:28 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/88624 |