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Degradable polycaprolactone nanoparticles stabilized via supramolecular host–guest interactions with pH-responsive polymer-pillar[5]arene conjugates

Title data

Wei, Peng ; Sobotta, Fabian H. ; Kellner, Carolin ; Bandelli, Damiano ; Hoeppener, Stephanie ; Schubert, Stephanie ; Brendel, Johannes C. ; Schubert, Ulrich S.:
Degradable polycaprolactone nanoparticles stabilized via supramolecular host–guest interactions with pH-responsive polymer-pillar[5]arene conjugates.
In: Polymer Chemistry. Vol. 11 (2020) Issue 12 . - pp. 1985-1997.
ISSN 1759-9954
DOI: https://doi.org/10.1039/C9PY01928F

Abstract in another language

Smart nano-carriers such as micelles, vesicles or nanoparticles constructed from amphiphilic polymers promise a new generation of drug delivery systems featuring localized and controlled release. Keeping the considerable effort for the synthesis of these polymers in mind, supramolecular host–guest interactions represent an interesting alternative to engineer amphiphilic materials with multiple functionalities. Using the known interaction of pillar[5]arenes with aromatic guests such as viologen-derivatives, we designed quasi-block copolymers based on polycaprolactone (PCL) and either the neutral and biocompatible poly(N-acryloyl morpholine) (PNAM-P[5]) or the structurally similar but pH-responsive poly(N-acryloyl-N′-methyl piperazine) (PNAMP-P[5]), which were modified with the pillar[5]arene. Self-assembly experiments in water resulted in the formation of small spherical nanostructures for the methyl viologen-polycaprolactone (viologen-PCL), but surprisingly also for the non-functionalized PCL. However, only the pH-responsive PNAMP-P[5] provided stable structures in the buffer for both cases, while PNAM-P[5] resulted in aggregation. Additional degradation studies revealed that the presence of host–guest complexes could retard the disintegration of the particles at low pH (5.1) in comparison to the particles based on plain PCL, while all structures remained stable at neutral pH value. In combination with their excellent biocompatibility, the presented supramolecular approach to stabilize PCL nanoparticles with pH-responsive polymers pave a convenient way to degradable delivery systems with tailored release profiles.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry I
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry I > Chair Macromolecular Chemistry I - Univ.-Prof. Dr. Johannes C. Brendel
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 20 Feb 2024 11:56
Last Modified: 02 May 2024 07:39
URI: https://eref.uni-bayreuth.de/id/eprint/88627