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Challenges and recent advancements in the synthesis of α,α-disubstituted α-amino acids

Title data

Zhang, Yu ; Vanderghinste, Jaro ; Wang, Jinxin ; Das, Shoubhik:
Challenges and recent advancements in the synthesis of α,α-disubstituted α-amino acids.
In: Nature Communications. Vol. 15 (2024) Issue 1 . - 1474.
ISSN 2041-1723
DOI: https://doi.org/10.1038/s41467-024-45790-2

Abstract in another language

α,α-Disubstituted α-amino acids (α-AAs) have improved properties compared to other types of amino acids. They serve as modifiers of peptide conformation and as precursors of bioactive compounds. Therefore, it has been a long-standing goal to construct this highly valuable scaffold efficiently in organic synthesis and drug discovery. However, access to α,α-disubstituted α-AAs is highly challenging and largely unexplored due to their steric constraints. To overcome these, remarkable advances have been made in the last decades. Emerging strategies such as synergistic enantioselective catalysis, visible-light-mediated photocatalysis, metal-free methodologies and CO2 fixation offer new avenues to access the challenging synthesis of α,α-disubstituted α-AAs and continuously bring additional contributions to this field. This review article aims to provide an overview of the recent advancements since 2015 and discuss existing challenges for the synthesis of α,α-disubstituted α-AAs and their derivatives.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Organic Chemistry I
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Organic Chemistry I > Chair Organic Chemistry I - Univ.-Prof. Dr. Das Shoubhik
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 22 Feb 2024 08:12
Last Modified: 22 Feb 2024 08:12
URI: https://eref.uni-bayreuth.de/id/eprint/88664