Activity of (η⁶-arene)dichloridoruthenium(II) complexes with antifungal imidazolyl-based ligands against Toxoplasma gondii and Leishmania major

Title data

Al Nasr, Ibrahim S. ; Daoud, Ismail ; Koko, Waleed S. ; Khan, Tariq A. ; Schobert, Rainer ; Ben Said, Ridha ; Amdouni, Noureddine ; Rahali, Seyfeddine ; Al-Ghamdi, Ali O. ; Biersack, Bernhard:
Activity of (η⁶-arene)dichloridoruthenium(II) complexes with antifungal imidazolyl-based ligands against Toxoplasma gondii and Leishmania major.
In: Inorganica Chimica Acta. Vol. 565 (2024) . - 122005.
ISSN 0020-1693
DOI: https://doi.org/10.1016/j.ica.2024.122005

Official URL:

Abstract in another language

A series of six (η⁶-arene)Ru(II) complexes with antifungal imidazole drug ligands such as clotrimazole, bifonazole and climbazole was prepared and analyzed. They were tested for their activities against Leishmania major and Toxoplasma gondii parasites, and were compared with the activities of the metal-free azole ligands. Activities superior to those of the azole ligands were observed for the Ru complexes, which indicate the beneficial role of the (η⁶-arene)ruthenium(II) moiety in terms of antiparasitic properties. The modifications of the arene ligand also played a role in the biological activity. Docking of selected ruthenium complexes into T. gondii kinase CDPK1 and ADME-T calculations revealed promising binding affinities and drug-like properties.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Keywords:	Ruthenium; Azoles; Clotrimazole; Bifonazole; CDPK1; Neglected tropical diseases
Institutions of the University:	Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Organic Chemistry I - Univ.-Prof. Dr. Rainer Schobert Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Result of work at the UBT:	Yes
DDC Subjects:	500 Science > 540 Chemistry
Date Deposited:	19 Oct 2024 21:00
Last Modified:	21 Oct 2024 09:46
URI:	https://eref.uni-bayreuth.de/id/eprint/90772