at Google ScholarTitle data
Senapati, Sudip ; Kumar Hota, Sudhir ; Kloene, Lennard ; Empel, Claire ; Murarka, Sandip ; Koenigs, Rene M.:
C−H Alkylation of Heterocycles via Light‐Mediated Palladium Catalysis.
In: Angewandte Chemie International Edition.
Vol. 64
(2025)
.
- e202417107.
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.202417107
Abstract in another language
Methods enabling direct C−H alkylation of heterocycles are of fundamental importance in the late-stage modification of natural products, bioactive molecules, and medicinally relevant compounds. However, there is a scarcity of a general strategy for the direct C−H alkylation of a variety of heterocycles using commercially available alkyl surrogates. We report an operationally simple palladium-catalyzed direct C−H alkylation of heterocycles using alkyl halides under the visible light irradiation with good scalability and functional group tolerance. Our studies suggest that the photoinduced alkylation proceeds through a cascade of events comprising, site-selective alkyl radical addition, base-assisted deprotonation, and oxidation. A combination of experiments and computations was employed for the generalization of this strategy, which was successfully translated towards the modification of natural products and pharmaceuticals.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Date Deposited: | 28 Mar 2025 07:30 |
| Last Modified: | 28 Mar 2025 07:30 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/93010 |