at Google ScholarTitle data
Yang, Zhen ; Pei, Chao ; Koenigs, Rene M.:
Access to gem-Difluoro Olefins via C–H Functionalization and Dual Role of Anilines.
In: Organic Letters.
Vol. 22
(2020)
.
- pp. 7234-7238.
ISSN 1523-7052
DOI: https://doi.org/10.1021/acs.orglett.0c02568
Abstract in another language
In this Letter, we describe a simple, practical approach in which cheap CuI was used as a catalyst to introduce a gem-difluoro olefin onto simple electron-rich aniline derivatives in good yield via direct C–H functionalization and a subsequent HF elimination reaction. Detailed mechanistic studies point at a dual role of aniline derivatives in this reaction, which serve as a substrate and a basic promoter to trigger the HF elimination step.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Organic Chemistry II - Bioorganic Chemistry > Chair Organic Chemistry II - Bioorganic Chemistry - Univ.-Prof. Dr. René M. Koenigs |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science > 540 Chemistry |
| Date Deposited: | 01 Apr 2025 13:26 |
| Last Modified: | 14 May 2025 07:54 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/93132 |