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First Highly Enantioselective Synthesis of Benzodiazepinones by Catalytic Hydrogenation

Title data

Rueping, Magnus ; Merino, Estíbaliz ; Koenigs, Rene M.:
First Highly Enantioselective Synthesis of Benzodiazepinones by Catalytic Hydrogenation.
In: Advanced Synthesis & Catalysis. Vol. 352 (2010) . - pp. 2629-2634.
ISSN 1615-4169
DOI: https://doi.org/10.1002/adsc.201000547

Abstract in another language

The first catalytic enantioselective synthesis of benzodiazepinones employing an efficient hydrogenation protocol has been developed. The corresponding products are obtained in good yields, with excellent enantioselectivities and broad functional group tolerance. In addition, a one-pot procedure involving in situ generation of benzodiazepin-2-ones followed by asymmetric reduction is presented.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Organic Chemistry II - Bioorganic Chemistry > Chair Organic Chemistry II - Bioorganic Chemistry - Univ.-Prof. Dr. René M. Koenigs
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 03 Apr 2025 12:29
Last Modified: 14 May 2025 07:54
URI: https://eref.uni-bayreuth.de/id/eprint/93214