Innovative approaches to the synthesis of five-membered heteroaromatics with emerging synthetic methodologies

Title data

Zhang, Yu ; Li, Qiannan ; Hu, Zhimin ; Leng, Zhiyong ; Zhang, Wei-dong ; Das, Shoubhik:
Innovative approaches to the synthesis of five-membered heteroaromatics with emerging synthetic methodologies.
In: Chemical Society Reviews. (2026) .
ISSN 1460-4744
DOI: https://doi.org/10.1039/D5CS01300C

Official URL:

Abstract in another language

According to statistics, more than 70 of drugs that are available on the market contain heterocyclic units. Among them, five-membered heteroaromatics bearing nitrogen, oxygen, and sulfur have served as the most important structural motifs found in diverse pharmaceuticals. Emerging toolboxes, such as photocatalysis, biocatalysis, electrocatalysis and skeletal editing have showcased unprecedented avenues to access them. In fact, >300 publications on the topic of synthesis of five-membered heteroaromatics by using emerging toolboxes have been recorded in the last ten years, clearly indicating the significance of this field. In this study, a conceptual overview and discussions are presented to showcase the advancement of this field. Moreover, the related drugs and bioactive compounds obtained by these approaches are highlighted.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Institutions of the University:	Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Organic Chemistry I - Photo- und Elektrokatalyse für Nachhaltigkeit > Chair Organic Chemistry I - Photo- und Elektrokatalyse für Nachhaltigkeit - Univ.-Prof. Dr. Shoubhik Das
Result of work at the UBT:	Yes
DDC Subjects:	500 Science > 540 Chemistry
Date Deposited:	19 Mar 2026 07:16
Last Modified:	19 Mar 2026 07:16
URI:	https://eref.uni-bayreuth.de/id/eprint/96618