Electrospun poly-l-lacticle nanofibres as scaffolds for tissue engineering

Title data

Boudriot, Ulrich ; Dersch, Roland ; Götz, Bernhard ; Griss, P. ; Greiner, Andreas ; Wendorff, Joachim H.:
Electrospun poly-l-lacticle nanofibres as scaffolds for tissue engineering.
In: Biomedizinische Technik. Vol. 49 (2004) Issue 9 . - pp. 242-247.
ISSN 1862-278X
DOI: https://doi.org/10.1515/BMT.2004.046

Official URL:

Abstract in another language

Tissue engineering is a promising tool for treating structural and functional defects in bone and cartilage. To provide optimal conditions for three-dimensional cell growth the use of a scaffold is necessary. The aim of the study was to test the potential application of an electrospun poly (I-lactide)-nanostructured scaffold as a matrix for tissue engineering. Matrices were seeded with human osteosarcoma MG-63 cells and cultivated for 14 days. Cells showed a clear preference for growth along the nanofibres, and demonstrated no signs of degeneration or apoptosis. The fine structure of electrospun nanofibres makes them an ideal scaffold for tissue engineering, in particular for cartilage repair. They can be ``doped'' with growth factors, medications, etc., and are both biocompatible and biodegradable.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Keywords:	nanofibres; tissue engineering; polylactide absorbable biomaterials
Institutions of the University:	Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Result of work at the UBT:	No
DDC Subjects:	500 Science > 540 Chemistry
Date Deposited:	14 Apr 2015 06:06
Last Modified:	25 Apr 2022 12:10
URI:	https://eref.uni-bayreuth.de/id/eprint/9712