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Costanzo, Michael ; VanderSluis, Benjamin ; Koch, Elizabeth N. ; Baryshnikova, Anastasia ; Pons, Carles ; Tan, Guihong ; Wang, Wen ; Usaj, Matej ; Hanchard, Julia ; Lee, Susan D. ; Pelechano, Vicent ; Styles, Erin B. ; Billmann, Maximilian ; van Leeuwen, Jolanda ; van Dyk, Nydia ; Lin, Zhen-Yuan ; Kuzmin, Elena ; Nelson, Justin ; Piotrowski, Jeff S. ; Srikumar, Tharan ; Bahr, Sondra ; Chen, Yiqun ; Deshpande, Raamesh ; Kurat, Christoph F. ; Li, Sheena C. ; Li, Zhijian ; Usaj, Mojca Mattiazzi ; Okada, Hiroki ; Pascoe, Natasha ; San Luis, Bryan-Joseph ; Sharifpoor, Sara ; Shuteriqi, Emira ; Simpkins, Scott W. ; Snider, Jamie ; Suresh, Harsha Garadi ; Tan, Yizhao ; Zhu, Hongwei ; Malod-Dognin, Noel ; Janjic, Vuk ; Przulj, Natasa ; Troyanskaya, Olga G. ; Stagljar, Igor ; Xia, Tian ; Ohya, Yoshikazu ; Gingras, Anne-Claude ; Raught, Brian ; Boutros, Michael ; Steinmetz, Lars M. ; Moore, Claire L. ; Rosebrock, Adam P. ; Caudy, Amy A. ; Myers, Chad L. ; Andrews, Brenda ; Boone, Charles:
A global genetic interaction network maps a wiring diagram of cellular function.
In: Science.
Bd. 353
(2016)
Heft 6306
.
ISSN 1095-9203
DOI: https://doi.org/10.1126/science.aaf1420
Abstract
We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing more than 23 million double mutants, identifying about 550,000 negative and about 350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential genes as densely connected hubs. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to protein complexes and pathways, biological processes, and cellular compartments. Negative interactions connected functionally related genes, mapped core bioprocesses, and identified pleiotropic genes, whereas positive interactions often mapped general regulatory connections among gene pairs, rather than shared functionality. The global network illustrates how coherent sets of genetic interactions connect protein complex and pathway modules to map a functional wiring diagram of the cell.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften |
| Eingestellt am: | 06 Aug 2026 07:57 |
| Letzte Änderung: | 06 Aug 2026 07:57 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/99209 |