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Kurat, Christoph F. ; Lambert, Jean-Philippe ; Petschnigg, Julia ; Friesen, Helena ; Pawson, Tony ; Rosebrock, Adam ; Gingras, Anne-Claude ; Fillingham, Jeffrey ; Andrews, Brenda:
Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation.
In: Proceedings of the National Academy of Sciences of the United States of America.
Bd. 111
(2014)
Heft 39
.
- S. 14124-14129.
ISSN 1091-6490
DOI: https://doi.org/10.1073/pnas.1414024111
Abstract
DNA replication occurs during the synthetic (S) phase of the eukaryotic cell cycle and features a dramatic induction of histone gene expression for concomitant chromatin assembly. Ectopic production of core histones outside of S phase is toxic, underscoring the critical importance of regulatory pathways that ensure proper expression of histone genes. Several regulators of histone gene expression in the budding yeast Saccharomyces cerevisiae are known, yet the key oscillator responsible for restricting gene expression to S phase has remained elusive. Here, we show that suppressor of Ty (Spt)10, a putative histone acetyltransferase, and its binding partner Spt21 are key determinants of S-phase-specific histone gene expression. We show that Spt21 abundance is restricted to S phase in part by anaphase promoting complex Cdc20-homologue 1 (APC(Cdh1)) and that it is recruited to histone gene promoters in S phase by Spt10. There, Spt21-Spt10 enables the recruitment of a cascade of regulators, including histone chaperones and the histone-acetyltransferase general control nonderepressible (Gcn) 5, which we hypothesize lead to histone acetylation and consequent transcription activation.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften |
| Eingestellt am: | 06 Aug 2026 07:56 |
| Letzte Änderung: | 06 Aug 2026 07:56 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/99210 |