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Ryan, Owen ; Shapiro, Rebecca S. ; Kurat, Christoph F. ; Mayhew, David ; Baryshnikova, Anastasia ; Chin, Brian ; Lin, Zhen-Yuan ; Cox, Michael J. ; Vizeacoumar, Frederick ; Cheung, Doris ; Bahr, Sondra ; Tsui, Kyle ; Tebbji, Faiza ; Sellam, Adnane ; Istel, Fabian ; Schwarzmüller, Tobias ; Reynolds, Todd B. ; Kuchler, Karl ; Gifford, David K. ; Whiteway, Malcolm ; Giaever, Guri ; Nislow, Corey ; Costanzo, Michael ; Gingras, Anne-Claude ; Mitra, Robi David ; Andrews, Brenda ; Fink, Gerald R. ; Cowen, Leah E. ; Boone, Charles:
Global gene deletion analysis exploring yeast filamentous growth.
In: Science.
Bd. 337
(2012)
Heft 6100
.
- S. 1353-1356.
ISSN 1095-9203
DOI: https://doi.org/10.1126/science.1224339
Abstract
The dimorphic switch from a single-cell budding yeast to a filamentous form enables Saccharomyces cerevisiae to forage for nutrients and the opportunistic pathogen Candida albicans to invade human tissues and evade the immune system. We constructed a genome-wide set of targeted deletion alleles and introduced them into a filamentous S. cerevisiae strain, Σ1278b. We identified genes involved in morphologically distinct forms of filamentation: haploid invasive growth, biofilm formation, and diploid pseudohyphal growth. Unique genes appear to underlie each program, but we also found core genes with general roles in filamentous growth, including MFG1 (YDL233w), whose product binds two morphogenetic transcription factors, Flo8 and Mss11, and functions as a critical transcriptional regulator of filamentous growth in both S. cerevisiae and C. albicans.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften |
| Eingestellt am: | 06 Aug 2026 07:36 |
| Letzte Änderung: | 06 Aug 2026 07:36 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/99214 |