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Sharifpoor, Sara ; Nguyen Ba, Alex N. ; Youn, Ji-Young ; van Dyk, Dewald ; Friesen, Helena ; Douglas, Alison C. ; Kurat, Christoph F. ; Chong, Yolanda T. ; Founk, Karen ; Moses, Alan M. ; Andrews, Brenda J.:
A quantitative literature-curated gold standard for kinase-substrate pairs.
In: Genome Biology.
Bd. 12
(2011)
.
- R39.
ISSN 1465-6906
DOI: https://doi.org/10.1186/gb-2011-12-4-r39
Abstract
We describe the Yeast Kinase Interaction Database (KID, http://www.moseslab.csb.utoronto.ca/KID/), which contains high- and low-throughput data relevant to phosphorylation events. KID includes 6,225 low-throughput and 21,990 high-throughput interactions, from greater than 35,000 experiments. By quantitatively integrating these data, we identified 517 high-confidence kinase-substrate pairs that we consider a gold standard. We show that this gold standard can be used to assess published high-throughput datasets, suggesting that it will enable similar rigorous assessments in the future.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften |
| Eingestellt am: | 06 Aug 2026 07:33 |
| Letzte Änderung: | 06 Aug 2026 07:33 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/99219 |