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Zanghellini, Jürgen ; Natter, Klaus ; Jungreuthmayer, Christian ; Thalhammer, Armin ; Kurat, Christoph F. ; Gogg-Fassolter, Gabriela ; Kohlwein, Sepp D. ; von Grünberg, Hans-Hennig:
Quantitative modeling of triacylglycerol homeostasis in yeast : metabolic requirement for lipolysis to promote membrane lipid synthesis and cellular growth.
In: The FEBS Journal.
Bd. 275
(2008)
Heft 22
.
- S. 5552-5563.
ISSN 1742-4658
DOI: https://doi.org/10.1111/j.1742-4658.2008.06681.x
Abstract
Triacylglycerol metabolism in Saccharomyces cerevisiae was analyzed quantitatively using a systems biological approach. Cellular growth, glucose uptake and ethanol secretion were measured as a function of time and used as input for a dynamic flux-balance model. By combining dynamic mass balances for key metabolites with a detailed steady-state analysis, we trained a model network and simulated the time-dependent degradation of cellular triacylglycerol and its interaction with fatty acid and membrane lipid synthesis. This approach described precisely, both qualitatively and quantitatively, the time evolution of various key metabolites in a consistent and self-contained manner, and the predictions were found to be in excellent agreement with experimental data. We showed that, during pre-logarithmic growth, lipolysis of triacylglycerol allows for the rapid synthesis of membrane lipids, whereas de novo fatty acid synthesis plays only a minor role during this growth phase. Progress in triacylglycerol hydrolysis directly correlates with an increase in cell size, demonstrating the importance of lipolysis for supporting efficient growth initiation.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie |
| Titel an der UBT entstanden: | Nein |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften |
| Eingestellt am: | 06 Aug 2026 07:30 |
| Letzte Änderung: | 06 Aug 2026 07:30 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/99223 |