Brassinosteroid-regulated transcription factors confer epigenetic changes that repress plant immunity

Titelangaben

Ramirez, Veronica E. ; Shuai, Haiwei ; Hwu, Fang-Yu ; Hazarika, Rashmi R. ; Tao, Chia-Nan ; Choi, Sera ; Piecyk, Robert S. ; Wudy, Susanne I. ; Gigl, Michael ; Bagnoli, Johannes W. ; Brajkovic, Sarah ; Albertos, Pablo ; Liang, Yuanyuan ; Keymer, Andreas ; Dawid, Corinna ; Enard, Wolfgang ; Vlot, A. Corina ; Gutjahr, Caroline ; Parniske, Martin ; Kuster, Bernhard ; Sieberer, Tobias ; Ludwig, Christina ; Zipfel, Cyril ; Ton, Jurriaan ; Johannes, Frank ; Poppenberger, Brigitte:
Brassinosteroid-regulated transcription factors confer epigenetic changes that repress plant immunity.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 123 (2026) Heft 34 . - e2532739123.
ISSN 1091-6490
DOI: https://doi.org/10.1073/pnas.2532739123

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Abstract

When organisms encounter pathogens, they rapidly activate complex defense programs to ensure survival. While these immune responses are vital, they often also incur trade-offs, such as reduced growth and development and must therefore be tightly controlled. In this study, we reveal that the steroid hormones brassinosteroids (BRs) contribute to this control in Arabidopsis thaliana by repressing immunity-related genes. We provide evidence that the BR-regulated basic helix–loop–helix (bHLH) transcription factor CESTA (CES), along with its homologs BR ENHANCED EXPRESSION (BEE)1-3, mediate DNA methylation changes at transposable element (TE)-rich loci containing nucleotide-binding leucine-rich-repeat (NLR)-type receptor genes, including SUPPRESSOR OF NPR1-1 CONSTITUTIVE 1 (SNC1). These CES-induced methylation changes correlate with altered splicing of SNC1 pre-mRNA, a process that requires the BR receptor BRASSINOSTEROID INSENSITIVE 1 (BRI1). In support, we show that CES associates with components of the chromatin remodeling and splicing machinery. Together, our findings reveal a previously unrecognized BR-induced mechanism that modulates the epigenetic and post transcriptional regulation of immune genes, enabling plants to prioritize growth over defense.