General and sustainable synthesis of benzoimidazopyrimidinones and -thiones

Titelangaben

Leowsky-Künstler, Felix ; Irrgang, Torsten ; Kempe, Rhett:
General and sustainable synthesis of benzoimidazopyrimidinones and -thiones.
In: Journal of Catalysis. Bd. 461 (2026) . - 117045.
ISSN 0021-9517
DOI: https://doi.org/10.1016/j.jcat.2026.117045

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Abstract

N-Heterocyclic compounds play a key role in chemistry and the life sciences and their (sustainable) synthesis is of great general interest. We report here on the synthesis of 3,4-dihydrobenzo4,5imidazo1,2–cpyrimidin-1(2H)-ones and −thiones. Our reaction is a consecutive three-component reaction using simple and readily available starting materials, such as benzene-1,2-diamines, 3-aminopropan-1-ols and 1,1́-carbonyldiimidazole or 1,1́-thiocarbonyldiimidazole. The reaction is mediated by a well-defined 3d-metal catalyst that is a manganese pincer complex and hydrogen is liberated during the reaction. All benzoimidazopyrimidinone and −thione examples synthesised haven’t been reported in literature yet.