Veröffentlichungen "You, Weijie"

2024

You, Weijie ; Montoya, Alba L. ; Dana, Srikanta ; Franzini, Raphael M. ; Steegborn, Clemens:
Elucidating the Unconventional Binding Mode of a DNA‐Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development.
In: ChemMedChem. (2024) . - e202400273.
ISSN 1860-7187
DOI: https://doi.org/10.1002/cmdc.202400273

2021

You, Weijie ; Steegborn, Clemens:
Binding site for activator MDL-801 on SIRT6.
In: Nature Chemical Biology. Bd. 17 (1 März 2021) . - S. 519-521.
ISSN 1552-4469
DOI: https://doi.org/10.1038/s41589-021-00749-y

2020

You, Weijie ; Steegborn, Clemens:
Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin.
In: ACS Medicinal Chemistry Letters. Bd. 11 (2020) Heft 11 . - S. 2285-2289.
ISSN 1948-5875
DOI: https://doi.org/10.1021/acsmedchemlett.0c00407

2019

You, Weijie:
Activation and inhibition of Sirt6 by small molecules.
Bayreuth , 2019 . - 120 S.
( Dissertation, 2019 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00004450

You, Weijie ; Zheng, Wei ; Weiß, Sandra ; Chua, Katrin F. ; Steegborn, Clemens:
Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.
In: Scientific Reports. Bd. 9 (2019) . - 19176.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-019-55654-1

2018

You, Weijie ; Steegborn, Clemens:
Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A : Implications for Protein Deacylase Drug Development.
In: Journal of Medicinal Chemistry. Bd. 61 (2018) Heft 23 . - S. 10922-10928.
ISSN 1520-4804
DOI: https://doi.org/10.1021/acs.jmedchem.8b01455

2017

You, Weijie ; Rotili, Dante ; Li, Tie-Mei ; Kambach, Christian ; Meleshin, Marat ; Schutkowski, Mike ; Chua, Katrin F. ; Mai, Antonello ; Steegborn, Clemens:
Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.
In: Angewandte Chemie International Edition. Bd. 56 (2017) Heft 4 . - S. 1007-1011.
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.201610082