Veröffentlichungen "Moniot, Sébastien"

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Linder, Jürgen ; Hupfeld, Enrico ; Weyand, Michael ; Steegborn, Clemens ; Moniot, Sébastien:
Crystal structure of a class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aeruginosa.
In: Journal of Structural Biology. Bd. 211 (2020) Heft 2 . - 107534.
ISSN 1047-8477
DOI: https://doi.org/10.1016/j.jsb.2020.107534

Weber, Anna M. ; Kaiser, Jennifer ; Ziegler, Thea ; Pilsl, Sebastian ; Renzl, Christian ; Sixt, Lisa ; Pietruschka, Georg ; Moniot, Sébastien ; Kakoti, Ankana ; Juraschitz, Marc ; Schrottke, Stefanie ; Lledo Bryant, Laura ; Steegborn, Clemens ; Bittl, Robert ; Mayer, Günter ; Möglich, Andreas:
A blue light receptor that mediates RNA binding and translational regulation.
In: Nature Chemical Biology. Bd. 15 (2019) . - S. 1085-1092.
ISSN 1552-4469
DOI: https://doi.org/10.1038/s41589-019-0346-y

Pinto, Andrea ; El Ali, Zeina ; Moniot, Sébastien ; Tamborini, Lucia ; Steegborn, Clemens ; Foresti, Roberta ; de Micheli, Carlo:
Effects of 3-Bromo-4,5-dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase-1 Expression.
In: ChemistryOpen. Bd. 7 (2018) Heft 11 . - S. 858-864.
ISSN 2191-1363
DOI: https://doi.org/10.1002/open.201800185

Li, Jun ; Bonkowski, Michael S. ; Moniot, Sébastien ; Zhang, Dapeng ; Hubbard, Basil P. ; Ling, Alvin J. Y. ; Rajman, Luis A. ; Qin, Bo ; Lou, Zhenkun ; Gorbunova, Vera ; Aravind, L. ; Steegborn, Clemens ; Sinclair, David A.:
A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.
In: Science. Bd. 355 (2017) Heft 6331 . - S. 1312-1317.
ISSN 1095-9203
DOI: https://doi.org/10.1126/science.aad8242

de Oliveira, Rita Machado ; Vicente Miranda, Hugo ; Francelle, Laetitia ; Pinho, Raquel ; Szegö, Éva M. ; Martinho, Renato ; Munari, Francesca ; Lázaro, Diana F. ; Moniot, Sébastien ; Guerreiro, Patrícia ; Fonseca-Ornelas, Luis ; Marijanovic, Zrinka ; Antas, Pedro ; Gerhardt, Ellen ; Enguita, Francisco Javier ; Fauvet, Bruno ; Penque, Deborah ; Pais, Teresa Faria ; Tong, Qiang ; Becker, Stefan ; Kügler, Sebastian ; Lashuel, Hilal Ahmed ; Steegborn, Clemens ; Zweckstetter, Markus ; Outeiro, Tiago F.:
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
In: PLoS Biology. Bd. 15 (2017) Heft 4 . - No. e1002601.
ISSN 1545-7885
DOI: https://doi.org/10.1371/journal.pbio.1002601

Moniot, Sébastien ; Forgione, Mariantonietta ; Lucidi, Alessia ; Hailu, Gebremedhin S. ; Nebbioso, Angela ; Carafa, Vincenzo ; Baratta, Francesca ; Altucci, Lucia ; Giacché, Nicola ; Passeri, Daniela ; Pellicciari, Roberto ; Mai, Antonello ; Steegborn, Clemens ; Rotili, Dante:
Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2 : Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
In: Journal of Medicinal Chemistry. Bd. 60 (2017) Heft 6 . - S. 2344-2360.
ISSN 1520-4804
DOI: https://doi.org/10.1021/acs.jmedchem.6b01609

Quinti, Luisa ; Dayalan Naidu, Sharadha ; Träger, Ulrike ; Chen, Xiqun ; Kegel-Gleason, Kimberly ; Llères, David ; Connolly, Colúm ; Chopra, Vanita ; Low, Cho ; Moniot, Sébastien ; Sapp, Ellen ; Tousley, Adelaide R. ; Vodicka, Petr ; van Kanegan, Michael J. ; Kaltenbach, Linda S. ; Crawford, Lisa A. ; Fuszard, Matthew ; Higgins, Maureen ; Miller, James R. C. ; Farmer, Ruth E. ; Potluri, Vijay ; Samajdar, Susanta ; Meisel, Lisa ; Zhang, Ningzhe ; Snyder, Andrew ; Stein, Ross ; Hersch, Steven M. ; Ellerby, Lisa M. ; Weerapana, Eranthie ; Schwarzschild, Michael A. ; Steegborn, Clemens ; Leavitt, Blair R. ; Degterev, Alexei ; Tabrizi, Sarah J. ; Lo, Donald C. ; DiFiglia, Marian ; Thompson, Leslie M. ; Dinkova-Kostova, Albena T. ; Kazantsev, Aleksey G.:
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 114 (2017) Heft 23 . - S. E4676-E4685.
ISSN 1091-6490
DOI: https://doi.org/10.1073/pnas.1614943114

de Oliveira, Rita Machado ; Vicente Miranda, Hugo ; Francelle, Laetitia ; Pinho, Raquel ; Szegö, Éva M. ; Martinho, Renato ; Munari, Francesca ; Lázaro, Diana F. ; Moniot, Sébastien ; Guerreiro, Patrícia ; Fonseca, Luis ; Marijanovic, Zrinka ; Antas, Pedro ; Gerhardt, Ellen ; Enguita, Francisco Javier ; Fauvet, Bruno ; Penque, Deborah ; Pais, Teresa Faria ; Tong, Qiang ; Becker, Stefan ; Kügler, Sebastian ; Lashuel, Hilal Ahmed ; Steegborn, Clemens ; Zweckstetter, Markus ; Outeiro, Tiago F.:
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
In: PLoS Biology. Bd. 15 (2017) Heft 3 . - No. e2000374.
ISSN 1545-7885
DOI: https://doi.org/10.1371/journal.pbio.2000374

Sundriyal, Sandeep ; Moniot, Sébastien ; Mahmud, Zimam ; Yao, Shang ; di Fruscia, Paolo ; Reynolds, Christopher R. ; Dexter, David T. ; Sternberg, Michael J. E. ; Lam, Eric W.-F. ; Steegborn, Clemens ; Fuchter, Matthew J.:
Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.
In: Journal of Medicinal Chemistry. Bd. 60 (2017) Heft 5 . - S. 1928-1945.
ISSN 1520-4804
DOI: https://doi.org/10.1021/acs.jmedchem.6b01690

Valente, Sergio ; Mellini, Paolo ; Spallotta, Francesco ; Carafa, Vincenzo ; Nebbioso, Angela ; Polletta, Lucia ; Carnevale, Ilaria ; Saladini, Serena ; Trisciuoglio, Daniela ; Gabellini, Chiara ; Tardugno, Maria ; Zwergel, Clemens ; Cencioni, Chiara ; Atlante, Sandra ; Moniot, Sébastien ; Steegborn, Clemens ; Budriesi, Roberta ; Tafani, Marco ; del Bufalo, Donatella ; Altucci, Lucia ; Gaetano, Carlo ; Mai, Antonello:
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells.
In: Journal of Medicinal Chemistry. Bd. 59 (2016) Heft 4 . - S. 1471-1491.
ISSN 1520-4804
DOI: https://doi.org/10.1021/acs.jmedchem.5b01117

Quinti, Luisa ; Casale, Malcolm ; Moniot, Sébastien ; Pais, Teresa Faria ; van Kanegan, Michael J. ; Kaltenbach, Linda S. ; Pallos, Judit ; Lim, Ryan G. ; Naidu, Sharadha Dayalan ; Runne, Heike ; Meisel, Lisa ; Rauf, Nazifa Abdul ; Leyfer, Dmitriy ; Maxwell, Michelle M. ; Saiah, Eddine ; Landers, John E. ; Luthi-Carter, Ruth ; Abagyan, Ruben ; Dinkova-Kostova, Albena T. ; Steegborn, Clemens ; Marsh, J. Lawrence ; Lo, Donald C. ; Thompson, Leslie M. ; Kazantsev, Aleksey G.:
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.
In: Cell Chemical Biology. Bd. 23 (2016) Heft 7 . - S. 849-861.
ISSN 2451-9456
DOI: https://doi.org/10.1016/j.chembiol.2016.05.015

di Fruscia, Paolo ; Zacharioudakis, Emmanouil ; Liu, Chang ; Moniot, Sébastien ; Laohasinnarong, Sasiwan ; Khongkow, Mattaka ; Harrison, Ian F. ; Koltsida, Konstantina ; Reynolds, Christopher R. ; Schmidtkunz, Karin ; Jung, Manfred ; Chapman, Kathryn L. ; Steegborn, Clemens ; Dexter, David T. ; Sternberg, Michael J. E. ; Lam, Eric W.-F. ; Fuchter, Matthew J.:
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.
In: ChemMedChem. Bd. 10 (2015) Heft 1 . - S. 69-82.
ISSN 1860-7187
DOI: https://doi.org/10.1002/cmdc.201402431

Chen, Xiqun ; Wales, Pauline ; Quinti, Luisa ; Zuo, Fuxing ; Moniot, Sébastien ; Herisson, Fanny ; Rauf, Nazifa Abdul ; Wang, Hua ; Silverman, Richard B. ; Ayata, Cenk ; Maxwell, Michelle M. ; Steegborn, Clemens ; Schwarzschild, Michael A. ; Outeiro, Tiago F. ; Kazantsev, Aleksey G.:
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
In: PLoS One. Bd. 10 (2015) Heft 1 . - No. e0116919.
ISSN 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0116919

Kleinbölting, Silke ; Diaz, Ana ; Moniot, Sébastien ; van den Heuvel, Joop ; Weyand, Michael ; Levin, Lonny R. ; Buck, Jochen ; Steegborn, Clemens:
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 111 (2014) Heft 10 . - S. 3727-3732.
ISSN 1091-6490
DOI: https://doi.org/10.1073/pnas.1322778111

Moniot, Sébastien ; Schutkowski, Mike ; Steegborn, Clemens:
Crystal structure analysis of human Sirt2 and its ADP-ribose complex.
In: Journal of Structural Biology. Bd. 182 (2013) Heft 2 . - S. 136-143.
ISSN 1047-8477
DOI: https://doi.org/10.1016/j.jsb.2013.02.012

Lakshminarasimhan, Mahadevan ; Curth, Ute ; Moniot, Sébastien ; Mosalaganti, Shyamal ; Raunser, Stefan ; Steegborn, Clemens:
Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol.
In: Bioscience Reports. Bd. 33 (2013) Heft 3 . - S. 395-404.
ISSN 1573-4935
DOI: https://doi.org/10.1042/BSR20120121

Moniot, Sébastien ; Weyand, Michael ; Steegborn, Clemens:
Structures, substrates, and regulators of Mammalian sirtuins : opportunities and challenges for drug development.
In: Frontiers in Pharmacology. Bd. 3 (2012) . - 16.
ISSN 1663-9812
DOI: https://doi.org/10.3389/fphar.2012.00016

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