Veröffentlichungen "Hellmuth, Susanne"

2024

Hellmuth, Susanne ; Stemmann, Olaf:
In vitro reconstitution reveals requirement of Nek2a and cyclin A2 for Wapl-dependent removal of cohesin from prophase chromatin.
bioRxiv , 2024
DOI: https://doi.org/10.1101/2024.03.12.584565

Hellmuth, Susanne ; Stemmann, Olaf:
Requirement of Nek2a and cyclin A2 for Wapl-dependent removal of cohesin from prophase chromatin.
In: The EMBO Journal. Bd. 43 (2024) . - S. 5237-5259.
ISSN 1460-2075
DOI: https://doi.org/10.1038/s44318-024-00228-9

2023

Abdel-Salam, Ghada M. H. ; Hellmuth, Susanne ; Gradhand, Elise ; Käseberg, Stephan ; Winter, Jennifer ; Pabst, Ann-Sophie ; Eid, Maha M. ; Thiele, Holger ; Nürnberg, Peter ; Budde, Birgit S. ; Toliat, Mohammad Reza ; Brecht, Ines B. ; Schroeder, Christopher ; Gschwind, Axel ; Ossowski, Stephan ; Häuser, Friederike ; Rossmann, Heidi ; Abdel-Hamid, Mohamed S. ; Hegazy, Ibrahim ; Mohamed, Ahmed G. ; Schneider, Dominik T. ; Bertoli-Avella, Aida M. ; Bauer, Peter ; Pearring, Jillian N. ; Pfundt, Rolph ; Hoischen, Alexander ; Gilissen, Christian ; Strand, Dennis ; Zechner, Ulrich ; Tashkandi, Soha A. ; Faqeih, Eissa A. ; Stemmann, Olaf ; Strand, Susanne ; Bolz, Hanno J.:
Biallelic MAD2L1BP (p31ᶜᵒᵐᵉᵗ) mutation is associated with mosaic aneuploidy and juvenile granulosa cell tumors.
In: JCI Insight. Bd. 8 (2023) Heft 22 . - e170079.
ISSN 2379-3708
DOI: https://doi.org/10.1172/jci.insight.170079

2020

Hellmuth, Susanne:
The Caspase-like Cell Cycle Protease Separase : Upstream Regulations and Downstream Functions.
Bayreuth , 2020 . - 197 S.
( Dissertation, 2020 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00004919

Hellmuth, Susanne ; Gómez-H., Laura ; Pendás, Alberto M. ; Stemmann, Olaf:
Securin-independent regulation of separase by checkpoint-induced shugoshin–MAD2.
In: Nature. Bd. 580 (2020) . - S. 536-541.
ISSN 1476-4687
DOI: https://doi.org/10.1038/s41586-020-2182-3

Hellmuth, Susanne ; Stemmann, Olaf:
Separase-triggered apoptosis enforces minimal length of mitosis.
In: Nature. Bd. 580 (2020) . - S. 542-547.
ISSN 1476-4687
DOI: https://doi.org/10.1038/s41586-020-2187-y

2019

Henschke, Lars ; Frese, Matthias ; Hellmuth, Susanne ; Marx, Andreas ; Stemmann, Olaf ; Mayer, Thomas U.:
Identification of Bioactive Small Molecule Inhibitors of Separase.
In: ACS Chemical Biology. Bd. 14 (2019) Heft 10 . - S. 2155-2159.
ISSN 1554-8937
DOI: https://doi.org/10.1021/acschembio.9b00661

2018

Wild, Thomas ; Budzowska, Magda ; Hellmuth, Susanne ; Eibes, Susana ; Karemore, Gopal ; Barisic, Marin ; Stemmann, Olaf ; Choudhary, Chunaram:
Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint.
In: Cell Reports. Bd. 25 (2018) Heft 9 . - S. 2317-2328.
ISSN 2211-1247
DOI: https://doi.org/10.1016/j.celrep.2018.10.104

Hellmuth, Susanne ; Gutiérrez-Caballero, Cristina ; Llano, Elena ; Pendás, Alberto M. ; Stemmann, Olaf:
Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation.
In: The EMBO Journal. Bd. 37 (2018) Heft 22 . - e99184.
ISSN 1460-2075
DOI: https://doi.org/10.15252/embj.201899184

2015

Hellmuth, Susanne ; Rata, Scott ; Brown, Andreas ; Heidmann, Stefan ; Novak, Bela ; Stemmann, Olaf:
Human Chromosome Segregation Involves Multi-Layered Regulation of Separase by the Peptidyl-Prolyl-Isomerase Pin1.
In: Molecular Cell. Bd. 58 (2015) Heft 3 . - S. 495-506.
ISSN 1097-4164
DOI: https://doi.org/10.1016/j.molcel.2015.03.025

Hellmuth, Susanne ; Pöhlmann, Christopher ; Brown, Andreas ; Böttger, Franziska ; Sprinzl, Mathias ; Stemmann, Olaf:
Positive and Negative Regulation of Vertebrate Separase by Cdk1-Cyclin B1 May Explain Why Securin Is Dispensable.
In: The Journal of Biological Chemistry. Bd. 290 (2015) Heft 12 . - S. 8002-8010.
ISSN 1083-351X
DOI: https://doi.org/10.1074/jbc.M114.615310

2014

Hellmuth, Susanne ; Böttger, Franziska ; Pan, Cuiping ; Mann, Matthias ; Stemmann, Olaf:
PP2A delays APC/C-dependent degradation of separase-associated but not free securin.
In: The EMBO Journal. Bd. 33 (2014) Heft 10 . - S. 1134-1147.
ISSN 1460-2075
DOI: https://doi.org/10.1002/embj.201488098

2011

Schmidt, Oliver ; Kaul, Pia ; Hellmuth, Susanne ; Borst, Katharina ; Horn, Marcus A. ; Drake, Harold L.:
Novel [NiFe]- and [FeFe]-hydrogenase gene transcripts indicative of active facultative aerobes and obligate anaerobes in earthworm gut contents.
In: Applied and Environmental Microbiology. Bd. 77 (2011) Heft 17 . - S. 5842-5850.
ISSN 1098-5336
DOI: https://doi.org/10.1128/AEM.05432-11