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Structure and signaling mechanism of Per-ARNT-Sim domains

Title data

Möglich, Andreas ; Ayers, Rebecca A. ; Moffat, Keith:
Structure and signaling mechanism of Per-ARNT-Sim domains.
In: Structure. Vol. 17 (14 October 2009) Issue 10 . - pp. 1282-1294.
ISSN 0969-2126
DOI: https://doi.org/10.1016/j.str.2009.08.011

Project information

Project financing: National Institues of Health

Abstract in another language

Per-ARNT-Sim (PAS) domains serve as versatile sensor and interaction modules in signal transduction proteins. PAS sensors detect chemical and physical stimuli and regulate the activity of functionally diverse effector domains. In contrast to this chemical, physical, and functional diversity, the structure of the core of PAS domains is broadly conserved and comprises a five-stranded antiparallel beta sheet and several alpha helices. Signals originate within the conserved core and generate structural and dynamic changes predominantly within the beta sheet, from which they propagate via amphipathic alpha-helical and coiled-coil linkers at the N or C termini of the core to the covalently attached effector domain. Effector domains are typically dimeric; their activity appears to be largely regulated by signal-dependent changes in quaternary structure and dynamics. The signaling mechanisms of PAS and other signaling domains share common features, and these commonalities can be exploited to enable structure-based design of artificial photosensors and chemosensors.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: PubMed-ID: 16292304
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Andreas Möglich
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Professorship Biochemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 20 May 2015 06:33
Last Modified: 20 May 2015 06:33
URI: https://eref.uni-bayreuth.de/id/eprint/13608