Institutionen der Universität Bayreuth
Lehrstuhl Biochemie I - Proteinbiochemie der Signaltransduktion

Sun, Shan ; Fushimi, Makoto ; Rossetti, Thomas ; Kaur, Navpreet ; Ferreira, Jacob ; Miller, Michael ; Quast, Jonathan ; van den Heuvel, Joop ; Steegborn, Clemens ; Levin, Lonny R. ; Buck, Jochen ; Myers, Robert W. ; Kargman, Stacia ; Liverton, Nigel ; Meinke, Peter T. ; Huggins, David J.:
Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation".
In: Journal of Chemical Information and Modeling. Bd. 64 (2024) Heft 3 . - S. 1106.
DOI: https://doi.org/10.1021/acs.jcim.4c00068

You, Weijie ; Montoya, Alba L. ; Dana, Srikanta ; Franzini, Raphael M. ; Steegborn, Clemens:
Elucidating the Unconventional Binding Mode of a DNA‐Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development.
In: ChemMedChem. (2024) . - e202400273.
DOI: https://doi.org/10.1002/cmdc.202400273

Xu, Qianzhao ; Vogt, Arend ; Frechen, Fabian ; Yi, Chengwei ; Küçükerden, Melike ; Ngum, Neville ; Sitjà-Roqueta, Laia ; Greiner, Andreas ; Parri, Rhein ; Masana, Mercè ; Wenger, Nikolaus ; Wachten, Dagmar ; Möglich, Andreas:
Engineering Bacteriophytochrome-coupled Photoactivated Adenylyl Cyclases for Enhanced Optogenetic cAMP Modulation.
In: Journal of Molecular Biology. Bd. 436 (2024) Heft 5 . - 168257.
DOI: https://doi.org/10.1016/j.jmb.2023.168257

Meier, Stefanie S. M. ; Multamäki, Elina ; Ranzani, Américo Tavares ; Takala, Heikki ; Möglich, Andreas:
Multimodal Control of Bacterial Gene Expression by Red and Blue Light.
In: Braman, Jeffrey Carl (Hrsg.): Synthetic Biology : Methods and Protocols. 2nd Edition. - New York, NY : Humana Press, 2024 . - S. 463-477 . - (Methods in Molecular Biology ; 2760 )
DOI: https://doi.org/10.1007/978-1-0716-3658-9_26

García de Fuentes, Andrés ; Möglich, Andreas:
Reduction Midpoint Potential of a Paradigm Light-Oxygen-Voltage Receptor and its Modulation by Methionine Residues.
In: RSC Chemical Biology. Bd. 5 (2024) Heft 6 . - S. 530-543.
DOI: https://doi.org/10.1039/D4CB00056K

Pietruschka, Georg ; Ranzani, Américo Tavares ; Weber, Anna ; Patwari, Tejal ; Pilsl, Sebastia ; Renzl, Christian ; Otte, David M. ; Pyka, Daniel ; Möglich, Andreas ; Mayer, Günter:
An RNA Motif That Enables Optozyme Control and Light-Dependent Gene Expression in Bacteria and Mammalian Cells.
In: Advanced Science. Bd. 11 (2024) Heft 12 . - 2304519.
DOI: https://doi.org/10.1002/advs.202304519

Wang, Jinping ; Luo, Jinque ; Rotili, Dante ; Mai, Antonello ; Steegborn, Clemens ; Xu, Suowen ; Jin, Zheng Gen:
SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells.
In: Inflammation. Bd. 47 (2024) . - S. 323-332.
DOI: https://doi.org/10.1007/s10753-023-01911-5

Pannek, Martin ; Alhalabi, Zayan ; Tomaselli, Daniela ; Menna, Martina ; Fiorentino, Francesco ; Robaa, Dina ; Weyand, Michael ; Puhlmann, Maximilian ; Tomassi, Stefano ; Barreca, Federica ; Tafani, Marco ; Zaganjor, Elma ; Haigis, Marcia C. ; Sippl, Wolfgang ; Rotili, Dante ; Mai, Antonello ; Steegborn, Clemens:
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity.
In: Journal of Medicinal Chemistry. Bd. 67 (2024) Heft 3 . - S. 1843-1860.
DOI: https://doi.org/10.1021/acs.jmedchem.3c01496

Kynast, Josef:
Towards Modular Protein Detection : Computational Methods to Support the Design of Peptide-Binding Pockets.
Bayreuth , 2024 . - X, 83 S.
( Dissertation, 2024 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00007497

Adolph, Ramona S.:
Biochemical and structural characterization of the regulation of human Sirtuin 1 by small molecules and proteins.
Bayreuth , 2023 . - XIV, 192 S.
( Dissertation, 2020 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00005024

Kaiser, Jennifer:
Charakterisierung und Anwendung von PAL, eines blaulichtabhängig RNA-bindenden Proteins.
Bayreuth , 2023 . - IV, 110, xxiv S.
( Dissertation, 2020 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00005184

Noske, Jakob ; Kynast, Josef ; Lemm, Dominik ; Schmidt, Steffen ; Höcker, Birte:
PocketOptimizer 2.0 : A modular framework for computer‐aided ligand‐binding design.
In: Protein Science. Bd. 32 (2023) Heft 1 . - e4516.
DOI: https://doi.org/10.1002/pro.4516

Kynast, Josef ; Höcker, Birte:
Atligator Web: A Graphical User Interface for Analysis and Design of Protein–Peptide Interactions.
In: BioDesign Research. Bd. 5 (2023) . - 0011.
DOI: https://doi.org/10.34133/bdr.0011

Suenkel, Benjamin:
Bioanalytical an mechanistical analysis of isoform specific Sirtuin modulation.
Bayreuth , 2023 . - X, 112 S.
( Dissertation, 2016 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00003081

Rossetti, Thomas ; Ferreira, Jacob ; Ghanem, Lubna ; Buck, Hannes ; Steegborn, Clemens ; Myers, Robert W. ; Meinke, Peter T. ; Levin, Lonny R. ; Buck, Jochen:
Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.
In: Frontiers in Physiology. Bd. 14 (2023) . - 1163389.
DOI: https://doi.org/10.3389/fphys.2023.1163389

Höcker, Birte ; Lu, Peilong ; Glasgow, Anum ; Marks, Debora S. ; Chatterjee, Pranam ; Slusky, Joanna S. G. ; Schueler-Furman, Ora ; Huang, Possu:
How can the protein design community best support biologists who want to harness AI tools for protein structure prediction and design?
In: Cell Systems. Bd. 14 (2023) Heft 8 . - S. 629-632.
DOI: https://doi.org/10.1016/j.cels.2023.07.005

Dietler, Julia:
Mechanistische Charakterisierung und Anwendung von Light-oxygen-voltage Rezeptoren.
Bayreuth , 2023 . - 206 S.
( Dissertation, 2021 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00005846

Zwergel, Clemens ; Aventaggiato, Michele ; Garbo, Sabrina ; Di Bello, Elisabetta ; Fassari, Bruno ; Noce, Beatrice ; Castiello, Carola ; Lambona, Chiara ; Barreca, Federica ; Rotili, Dante ; Fioravanti, Rossella ; Schmalz, Thomas ; Weyand, Michael ; Niedermeier, Amelie ; Tripodi, Marco ; Colotti, Gianni ; Steegborn, Clemens ; Battistelli, Cecilia ; Tafani, Marco ; Valente, Sergio ; Mai, Antonello:
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells.
In: Journal of Medicinal Chemistry. Bd. 66 (2023) Heft 14 . - S. 9622-9641.
DOI: https://doi.org/10.1021/acs.jmedchem.3c00337

Balbach, Melanie ; Rossetti, Thomas ; Ferreira, Jacob ; Ghanem, Lubna ; Ritagliati, Carla ; Myers, Robert W. ; Huggins, David J. ; Steegborn, Clemens ; Miranda, Ileana C. ; Meinke, Peter T. ; Buck, Jochen ; Levin, Lonny R.:
On-demand male contraception via acute inhibition of soluble adenylyl cyclase.
In: Nature Communications. Bd. 14 (2023) Heft 1 . - 637.
DOI: https://doi.org/10.1038/s41467-023-36119-6

Kordes, Sina ; Beck, Julian ; Shanmugaratnam, Sooruban ; Flecks, Merle ; Höcker, Birte:
Physics-based approach to extend a de novo TIM barrel with rationally designed helix-loop-helix motifs.
In: Protein Engineering, Design & Selection. Bd. 36 (2023) . - gzad012.
DOI: https://doi.org/10.1093/protein/gzad012

Xu, Chengzhang ; Agarwal, Seema ; Möglich, Andreas ; Greiner, Andreas:
Polymer Chemistry : A primer to enzymatic polymer degradation.
In: Nachrichten aus der Chemie. Bd. 71 (2023) Heft 11 . - S. 38-40.
DOI: https://doi.org/10.1002/nadc.20234134889

Michel, Florian ; Romero-Romero, Sergio ; Höcker, Birte:
Retracing the evolution of a modern periplasmic binding protein.
In: Protein Science. Bd. 32 (2023) Heft 11 . - e4793.
DOI: https://doi.org/10.1002/pro.4793

Sun, Shan ; Fushimi, Makoto ; Rossetti, Thomas ; Kaur, Navpreet ; Ferreira, Jacob ; Miller, Michael ; Quast, Jonathan ; van den Heuvel, Joop ; Steegborn, Clemens ; Levin, Lonny R. ; Buck, Jochen ; Myers, Robert W. ; Kargman, Stacia ; Liverton, Nigel ; Meinke, Peter T. ; Huggins, David J.:
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
In: Journal of Chemical Information and Modeling. Bd. 63 (2023) Heft 9 . - S. 2828-2841.
DOI: https://doi.org/10.1021/acs.jcim.2c01577

Römling, Ute ; Möglich, Andreas:
Seeing the light brings more food in the deep sea.
In: The EMBO Journal. Bd. 42 (2023) Heft 12 . - e114091.
DOI: https://doi.org/10.15252/embj.2023114091

Michel, Florian ; Shanmugaratnam, Sooruban ; Romero-Romero, Sergio ; Höcker, Birte:
Structures of permuted halves of a modern ribose-binding protein.
In: Acta Crystallographica Section D Structural Biology. Bd. 79 (2023) . - S. 40-49.
DOI: https://doi.org/10.1107/S205979832201186X

Kordes, Sina:
TIM Barrels 2.0 – Stabilizing and Diversifying a De Novo Designed Protein.
Bayreuth , 2023 . - ii, 190 S.
( Dissertation, 2022 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00006859

Rossetti, Thomas ; Ferreira, Jacob ; Ghanem, Lubna ; Buck, Hannes ; Steegborn, Clemens ; Myers, Robert W. ; Meinke, Peter T. ; Levin, Lonny R. ; Buck, Jochen:
Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.
In: Frontiers in Physiology. Bd. 13 (2022) . - 1013845.
DOI: https://doi.org/10.3389/fphys.2022.1013845

Kynast, Josef ; Schwägerl, Felix ; Höcker, Birte:
ATLIGATOR : editing protein interactions with an atlas-based approach.
In: Bioinformatics. Bd. 38 (2022) Heft 23 . - S. 5199-5205.
DOI: https://doi.org/10.1093/bioinformatics/btac685

Towell, Holly:
Biochemical and structural characterisation of mammalian deiodinases as key regulators of thyroid hormone metabolism.
Bayreuth , 2022 . - X, 95 S.
( Dissertation, 2022 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00006054

Rhys, Guto G. ; Cross, Jessica A. ; Dawson, William M. ; Thompson, Harry F. ; Shanmugaratnam, Sooruban ; Savery, Nigel J. ; Dodding, Mark P. ; Höcker, Birte ; Woolfson, Derek N.:
De novo designed peptides for cellular delivery and subcellular localisation.
In: Nature Chemical Biology. Bd. 18 (2022) Heft 9 . - S. 999-1004.
DOI: https://doi.org/10.1038/s41589-022-01076-6

Miller, Michael ; Rossetti, Thomas ; Ferreira, Jacob ; Ghanem, Lubna ; Balbach, Melanie ; Kaur, Navpreet ; Levin, Lonny R. ; Buck, Jochen ; Kehr, Maria ; Coquille, Sandrine ; van den Heuvel, Joop ; Steegborn, Clemens ; Fushimi, Makoto ; Finkin-Groner, Efrat ; Myers, Robert W. ; Kargman, Stacia ; Liverton, Nigel J. ; Huggins, David J. ; Meinke, Peter T.:
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
In: Journal of Medicinal Chemistry. Bd. 65 (2022) Heft 22 . - S. 15208-15226.
DOI: https://doi.org/10.1021/acs.jmedchem.2c01133

Ferruz, Noelia ; Höcker, Birte:
Dreaming ideal protein structures.
In: Nature Biotechnology. Bd. 40 (2022) Heft 2 . - S. 171-172.
DOI: https://doi.org/10.1038/s41587-021-01196-9

Kateriya, Suneel ; Jha, Sushil K. ; Möglich, Andreas:
Editorial: New Horizons in Cellular Optogenetics.
In: Frontiers in Cellular Neuroscience. Bd. 16 (2022) . - 875602.
DOI: https://doi.org/10.3389/fncel.2022.875602

Rodriguez-Ruiz, Alfonso ; Braun, Doreen ; Pflug, Simon ; Brol, Alexander ; Sylvester, Marc ; Steegborn, Clemens ; Schweizer, Ulrich:
Insights into the Mechanism of Human Deiodinase 1.
In: International Journal of Molecular Sciences. Bd. 23 (2022) Heft 10 . - 5361.
DOI: https://doi.org/10.3390/ijms23105361

Weigert, Sebastian ; Perez‐Garcia, Pablo ; Gisdon, Florian J. ; Gagsteiger, Andreas ; Schweinshaut, Kristine ; Ullmann, G. Matthias ; Chow, Jennifer ; Streit, Wolfgang R. ; Höcker, Birte:
Investigation of the halophilic PET hydrolase PET6 from Vibrio gazogenes.
In: Protein Science. Bd. 31 (2022) Heft 12 . - e4500.
DOI: https://doi.org/10.1002/pro.4500

Xu, Chengzhang ; Battig, Alexander ; Schartel, Bernhard ; Siegel, Renée ; Senker, Jürgen ; von der Forst, Inge ; Unverzagt, Carlo ; Agarwal, Seema ; Möglich, Andreas ; Greiner, Andreas:
Investigation of the Thermal Stability of Proteinase K for the Melt Processing of Poly(l-lactide).
In: Biomacromolecules. Bd. 23 (2022) Heft 11 . - S. 4841-4850.
DOI: https://doi.org/10.1021/acs.biomac.2c01008

Ranzani, Américo Tavares ; Wehrmann, Markus ; Kaiser, Jennifer ; Juraschitz, Marc ; Weber, Anna M. ; Pietruschka, Georg ; Gerken, Uwe ; Mayer, Günter ; Möglich, Andreas:
Light-Dependent Control of Bacterial Expression at the mRNA Level.
In: ACS Synthetic Biology. Bd. 11 (2022) Heft 10 . - S. 3482-3492.
DOI: https://doi.org/10.1021/acssynbio.2c00365

Ohlendorf, Robert ; Möglich, Andreas:
Light-regulated Gene Expression in Bacteria : Fundamentals, Advances, and Perspectives.
In: Frontiers in Bioengineering and Biotechnology. Bd. 10 (2022) . - 1029403.
DOI: https://doi.org/10.3389/fbioe.2022.1029403

Gisdon, Florian J. ; Kynast, Josef ; Ayyildiz, Merve ; Hine, Anna V. ; Plückthun, Andreas ; Höcker, Birte:
Modular peptide binders : development of a predictive technology as alternative for reagent antibodies.
In: Biological Chemistry. Bd. 403 (2022) Heft 5-6 . - S. 535-543.
DOI: https://doi.org/10.1515/hsz-2021-0384

Kordes, Sina ; Romero-Romero, Sergio ; Lutz, Leonie ; Höcker, Birte:
A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels.
In: Protein Science. Bd. 31 (2022) Heft 2 . - S. 513-527.
DOI: https://doi.org/10.1002/pro.4249

Multamäki, Elina ; García de Funtes, Andrés ; Sieryi, Oleksii ; Bykov, Alexander ; Gerken, Uwe ; Ranzani, Américo Tavares ; Köhler, Jürgen ; Meglinski, Igor ; Möglich, Andreas ; Takala, Heikki:
Optogenetic Control of Bacterial Expression by Red Light.
In: ACS Synthetic Biology. Bd. 11 (2022) Heft 10 . - S. 3354-3367.
DOI: https://doi.org/10.1021/acssynbio.2c00259

Suenkel, Benjamin ; Valente, Sergio ; Zwergel, Clemens ; Weiss, Sandra ; Di Bello, Elisabetta ; Fioravanti, Rossella ; Aventaggiato, Michele ; Amorim, João A. ; Garg, Neha ; Kumar, Surinder ; Lombard, David B. ; Hu, Tuo ; Singh, Pankaj K. ; Tafani, Marco ; Palmeira, Carlos M. ; Sinclair, David ; Mai, Antonello ; Steegborn, Clemens:
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5.
In: Journal of Medicinal Chemistry. Bd. 65 (2022) Heft 20 . - S. 14015-14031.
DOI: https://doi.org/10.1021/acs.jmedchem.2c01215

Höcker, Birte ; Zielonka, Stefan:
Protein engineering & design : hitting new heights.
In: Biological Chemistry. Bd. 403 (2022) Heft 5-6 . - S. 453.
DOI: https://doi.org/10.1515/hsz-2022-0139

Ferruz, Noelia ; Schmidt, Steffen ; Höcker, Birte:
ProtGPT2 is a deep unsupervised language model for protein design.
In: Nature Communications. Bd. 13 (2022) . - 4348.
DOI: https://doi.org/10.1038/s41467-022-32007-7

Dietler, Julia ; Gelfert, Renate ; Kaiser, Jennifer ; Borin, Veniamin ; Renzl, Christian ; Pilsl, Sebastian ; Ranzani, Américo Tavares ; García de Funtes, Andrés ; Gleichmann, Tobias ; Diensthuber, Ralph P. ; Weyand, Michael ; Mayer, Günter ; Schapiro, Igor ; Möglich, Andreas:
Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine.
In: Nature Communications. Bd. 13 (2022) . - 2618.
DOI: https://doi.org/10.1038/s41467-022-30252-4

Ferruz, Noelia ; Höcker, Birte:
Controllable protein design with language models.
In: Nature Machine Intelligence. Bd. 4 (2022) . - S. 521-532.
DOI: https://doi.org/10.1038/s42256-022-00499-z

Weigert, Sebastian:
Investigation of PET-degrading enzymes and their implications on microplastics.
Bayreuth , 2022 . - IV, 112 S.
( Dissertation, 2022 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00006729

Weiss, Sandra ; Adolph, Ramona S. ; Schweimer, Kristian ; DiFonzo, Andrea ; Meleshin, Marat ; Schutkowski, Mike ; Steegborn, Clemens:
Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein.
In: International Journal of Molecular Sciences. Bd. 23 (2022) Heft 21 . - 12764.
DOI: https://doi.org/10.3390/ijms232112764

You, Weijie ; Steegborn, Clemens:
Binding site for activator MDL-801 on SIRT6.
In: Nature Chemical Biology. Bd. 17 (1 März 2021) . - S. 519-521.
DOI: https://doi.org/10.1038/s41589-021-00749-y

Lechner, Horst ; Emann, Vincent R. ; Breuning, Matthias ; Höcker, Birte:
An Artificial Cofactor Catalyzing the Baylis-Hillman Reaction with Designed Streptavidin as Protein Host.
In: ChemBioChem. Bd. 22 (2021) Heft 9 . - S. 1573-1577.
DOI: https://doi.org/10.1002/cbic.202000880

Zhang, Hongli ; Perez-Garcia, Pablo ; Dierkes, Robert F. ; Applegate, Violetta ; Schumacher, Julia ; Chibani, Cynthia Maria ; Sternagel, Stefanie ; Preuss, Lena ; Weigert, Sebastian ; Schmeisser, Christel ; Danso, Dominik ; Pleiss, Juergen ; Almeida, Alexandre ; Höcker, Birte ; Hallam, Steven J. ; Schmitz, Ruth A. ; Smits, Sander H. J. ; Chow, Jennifer ; Streit, Wolfgang R.:
The Bacteroidetes Aequorivita sp. and Kaistella jeonii Produce Promiscuous Esterases With PET-Hydrolyzing Activity.
In: Frontiers in Microbiology. Bd. 12 (2021) . - 803896.
DOI: https://doi.org/10.3389/fmicb.2021.803896

Weiß, Sandra:
Biochemische und strukturelle Charakterisierung der Regulation von Sirtuinen durch AROS und Kleinmoleküle.
Bayreuth , 2021 . - XV, 122 S.
( Dissertation, 2021 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00005910

Herud-Sikimić, Ole ; Stiel, André C. ; Kolb, Martina ; Shanmugaratnam, Sooruban ; Berendzen, Kenneth W. ; Feldhaus, Christian ; Höcker, Birte ; Jürgens, Gerd:
A biosensor for the direct visualization of auxin.
In: Nature. Bd. 592 (2021) Heft 7856 . - S. 768-772.
DOI: https://doi.org/10.1038/s41586-021-03425-2

Multamäki, Elina ; Nanekar, Rahul ; Morozov, Dmitry ; Lievonen, Topias ; Golonka, David ; Wahlgren, Weixiao Yuan ; Stucki-Buchli, Brigitte ; Rossi, Jari ; Hytönen, Vesa P. ; Westenhoff, Sebastian ; Ihalainen, Janne A. ; Möglich, Andreas ; Takala, Heikki:
Comparative analysis of two paradigm bacteriophytochromes reveals opposite functionalities in two-component signaling.
In: Nature Communications. Bd. 12 (2021) . - 4394.
DOI: https://doi.org/10.1038/s41467-021-24676-7

Ip, James E. ; Xu, Linna ; Dai, Jie ; Steegborn, Clemens ; Jaffré, Fabrice ; Evans, Todd ; Cheung, Jim W. ; Basson, Craig T. ; Panaghie, Gianina ; Krogh-Madsen, Trine ; Abbott, Geoffrey W. ; Lerman, Bruce B.:
Constitutively Activating GNAS Somatic Mutation in Right Ventricular Outflow Tract Tachycardia.
In: Circulation: Arrhythmia and Electrophysiology. Bd. 14 (2021) Heft 10 . - e010082.
DOI: https://doi.org/10.1161/CIRCEP.121.010082

Yuan Wahlgren, Weixiao ; Golonka, David ; Westenhoff, Sebastian ; Möglich, Andreas:
Cryo-electron microscopy of Arabidopsis thaliana phytochrome A in its Pr state reveals head-to-head homodimeric architecture.
In: Frontiers in Plant Science. Bd. 12 (2021) . - 663751.
DOI: https://doi.org/10.3389/fpls.2021.663751

Fushimi, Makoto ; Buck, Hannes ; Balbach, Melanie ; Gorovyy, Anna ; Ferreira, Jacob ; Rossetti, Thomas ; Kaur, Navpreet ; Levin, Lonny R. ; Buck, Jochen ; Quast, Jonathan ; van den Heuvel, Joop ; Steegborn, Clemens ; Finkin-Groner, Efrat ; Kargman, Stacia ; Michino, Mayako ; Foley, Michael A. ; Miller, Michael ; Liverton, Nigel J. ; Huggins, David J. ; Meinke, Peter T.:
Discovery of TDI-10229 : A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
In: ACS Medicinal Chemistry Letters. Bd. 12 (2021) Heft 8 . - S. 1283-1287.
DOI: https://doi.org/10.1021/acsmedchemlett.1c00273

Romero-Romero, Sergio ; Kordes, Sina ; Michel, Florian ; Höcker, Birte:
Evolution, folding, and design of TIM barrels and related proteins.
In: Current Opinion in Structural Biology. Bd. 68 (2021) . - S. 94-104.
DOI: https://doi.org/10.1016/j.sbi.2020.12.007

Wiese, Jonas Gregor ; Shanmugaratnam, Sooruban ; Höcker, Birte:
Extension of a de novo TIM barrel with a rationally designed secondary structure element.
In: Protein Science. Bd. 30 (2021) Heft 5 . - S. 982-989.
DOI: https://doi.org/10.1002/pro.4064

Kröger, Pascal ; Shanmugaratnam, Sooruban ; Scheib, Ulrike ; Höcker, Birte:
Fine-tuning spermidine binding modes in the putrescine binding protein PotF.
In: The Journal of Biological Chemistry. Bd. 297 (2021) Heft 6 . - 101419.
DOI: https://doi.org/10.15495/EPub_UBT_00006574

Ferruz, Noelia ; Michel, Florian ; Lobos, Francisco ; Schmidt, Steffen ; Höcker, Birte:
Fuzzle 2.0 : Ligand Binding in Natural Protein Building Blocks.
In: Frontiers in Molecular Biosciences. Bd. 8 (2021) . - 715972.
DOI: https://doi.org/10.15495/EPub_UBT_00006453

Orth, Barbara ; Sander, Bodo ; Möglich, Andreas ; Diederichs, Kay ; Eilers, Martin ; Lorenz, Sonja:
Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1.
In: Structure. Bd. 29 (2021) Heft 11 . - S. 1230-1240.
DOI: https://doi.org/10.1016/j.str.2021.06.005

Menzel, Teresa ; Weigert, Sebastian ; Gagsteiger, Andreas ; Eich, Yannik ; Sittl, Sebastian ; Papastavrou, Georg ; Ruckdäschel, Holger ; Altstädt, Volker ; Höcker, Birte:
Impact of Enzymatic Degradation on the Material Properties of Poly(Ethylene Terephthalate).
In: Polymers. Bd. 13 (2021) Heft 22 . - 3885.
DOI: https://doi.org/10.3390/polym13223885

Dietler, Julia ; Schubert, Roman ; Krafft, Tobias G. A. ; Meiler, Simone ; Kainrath, Stephanie ; Richter, Florian ; Schweimer, Kristian ; Weyand, Michael ; Janovjak, Harald ; Möglich, Andreas:
A Light-Oxygen-Voltage Receptor Integrates Light and Temperature.
In: Journal of Molecular Biology. Bd. 433 (2021) Heft 15 . - 167107.
DOI: https://doi.org/10.1016/j.jmb.2021.167107

Hu, Tuo ; Shukla, Surendra K. ; Vernucci, Enza ; He, Chunbo ; Wang, Dezhen ; King, Ryan J. ; Jha, Kanupriya ; Siddhanta, Kasturi ; Mullen, Nicholas J. ; Attri, Kuldeep S. ; Murthy, Divya ; Chaika, Nina V. ; Thakur, Ravi ; Mulder, Scott E. ; Pacheco, Camila G. ; Fu, Xiao ; High, Robin R. ; Yu, Fang ; Lazenby, Audrey ; Steegborn, Clemens ; Lan, Ping ; Mehla, Kamiya ; Rotili, Dante ; Chaudhary, Sarika ; Valente, Sergio ; Tafani, Marco ; Mai, Antonello ; Auwerx, Johan ; Verdin, Eric ; Tuveson, David ; Singh, Pankaj K.:
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.
In: Gastroenterology. Bd. 161 (2021) Heft 5 . - S. 1584-1600.
DOI: https://doi.org/10.1053/j.gastro.2021.06.045

Unverzagt, Carlo ; Reif, Andreas ; Lam, Kevin ; Weidler, Sascha ; Lott, Marie ; Boos, Irene ; Lokau, Juliane ; Bretscher, Christian ; Mönnich, Manuel ; Perkams, Lukas ; Schmälzlein, Marina ; Graf, Christopher G. F. ; Fischer, Jan-Patrick ; Lechner, Carolin ; Hallstein, Kerstin ; Becker, Stefan ; Weyand, Michael ; Steegborn, Clemens ; Schultheiss, Gerhard ; Rose-John, Stefan ; Garbers, Christoph:
Natural Glycoforms of Human Interleukin 6 show atypical plasma clearance.
In: Angewandte Chemie International Edition. Bd. 60 (2021) Heft 24 . - S. 13380-13387.
DOI: https://doi.org/10.1002/anie.202101496

Dietler, Julia ; Liang, Chen ; Frank, Saskia ; Müller, Ann-Kathrin ; Greiner, Andreas ; Möglich, Andreas:
Photobiologically Directed Assembly of Gold Nanoparticles.
In: Advanced Biology. Bd. 5 (2021) Heft 5 . - 2000179.
DOI: https://doi.org/10.1002/adbi.202000179

Ferruz, Noelia ; Schmidt, Steffen ; Höcker, Birte:
ProteinTools : a toolkit to analyze protein structures.
In: Nucleic Acids Research. Bd. 49 (2021) Heft W1 . - W559-W566.
DOI: https://doi.org/10.15495/EPub_UBT_00006493

Sokolovski, Serge G. ; Zherebtsov, Evgeny A. ; Kar, Rajiv K. ; Golonka, David ; Stabel, Robert ; Chichkov, Nikolai B. ; Gorodetsky, Andrey ; Schapiro, Igor ; Möglich, Andreas ; Rafailov, Edik U.:
Two-Photon Conversion of a Bacterial Phytochrome.
In: Biophysical Journal. Bd. 120 (2021) Heft 5 . - S. 964-974.
DOI: https://doi.org/10.1016/j.bpj.2021.01.028

Weigert, Sebastian ; Gagsteiger, Andreas ; Menzel, Teresa ; Höcker, Birte:
A versatile assay platform for enzymatic poly(ethylene-terephthalate) degradation.
In: Protein Engineering, Design & Selection. Bd. 34 (2021) . - S. 1-9.
DOI: https://doi.org/10.1093/protein/gzab022

Romero-Romero, Sergio ; Costas, Miguel ; Silva Manzano, Daniel-Adriano ; Kordes, Sina ; Rojas-Ortega, Erendira ; Tapia, Cinthya ; Guerra, Yasel ; Shanmugaratnam, Sooruban ; Rodríguez-Romero, Adela ; Baker, David ; Höcker, Birte ; Fernández-Velasco, D. Alejandro:
The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach.
In: Journal of Molecular Biology. Bd. 433 (2021) Heft 18 . - 167153.
DOI: https://doi.org/10.1016/j.jmb.2021.167153

Steegborn, Clemens ; Schweizer, Ulrich:
Structure and Mechanism of Iodothyronine Deiodinases : What We Know, What We Don't Know, and What Would Be Nice to Know.
In: Experimental and clinical endocrinology & diabetes. Bd. 128 (7 November 2020) Heft 6/7 . - S. 375-378.
DOI: https://doi.org/10.1055/a-1022-9916

Stabel, Robert:
Design neuer rotlichtaktivierter Enzyme zur Kontrolle von zyklischen Mononukleotiden.
Bayreuth , 2020 . - V, 132 S.
( Dissertation, 2019 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00004689

Golonka, David ; Gerken, Uwe ; Köhler, Jürgen ; Möglich, Andreas:
The Association Kinetics Encode the Light Dependence of Arabidopsis Phytochrome B Interactions.
In: Journal of Molecular Biology. Bd. 432 (2020) Heft 16 . - S. 4327-4340.
DOI: https://doi.org/10.1016/j.jmb.2020.06.001

Kleinboelting, Silke ; Miehling, Jonas ; Steegborn, Clemens:
Crystal structure and enzymatic characterization of the putative adenylyl cyclase HpAC1 from Hippeastrum reveal dominant triphosphatase activity.
In: Journal of Structural Biology. Bd. 212 (2020) Heft 3 . - 107649.
DOI: https://doi.org/10.1016/j.jsb.2020.107649

Linder, Jürgen ; Hupfeld, Enrico ; Weyand, Michael ; Steegborn, Clemens ; Moniot, Sébastien:
Crystal structure of a class III adenylyl cyclase-like ATP-binding protein from Pseudomonas aeruginosa.
In: Journal of Structural Biology. Bd. 211 (2020) Heft 2 . - 107534.
DOI: https://doi.org/10.1016/j.jsb.2020.107534

Ziegler, Thea:
Engineering and Characterization of RNA-binding LOV photoreceptors.
Bayreuth , 2020 . - 163 S.
( Dissertation, 2019 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00004692

Tomassi, Stefano ; Pfahler, Julian ; Mautone, Nicola ; Rovere, Anarita ; Esposito, Chiara ; Passeri, Daniela ; Pellicciari, Roberto ; Novellino, Ettore ; Pannek, Martin ; Steegborn, Clemens ; Paiardini, Alessandro ; Mai, Antonello ; Rotili, Dante:
From PARP1 to TNKS2 Inhibition : A Structure-Based Approach.
In: ACS Medicinal Chemistry Letters. Bd. 11 (2020) Heft 5 . - S. 862-868.
DOI: https://doi.org/10.1021/acsmedchemlett.9b00654

Ferruz, Noelia ; Lobos, Francisco ; Lemm, Dominik ; Toledo-Patiño, Saacnicteh ; Farías-Rico, José Arcadio ; Schmidt, Steffen ; Höcker, Birte:
Identification and Analysis of Natural Building Blocks for Evolution-Guided Fragment-Based Protein Design.
In: Journal of Molecular Biology. Bd. 432 (2020) Heft 13 . - S. 3898-3914.
DOI: https://doi.org/10.1016/j.jmb.2020.04.013

Hansen, Jan Niklas ; Kaiser, Fabian ; Klausen, Christina ; Stüven, Birthe ; Chong, Raymond ; Bönigk, Wolfgang ; Mick, David U. ; Möglich, Andreas ; Jurisch-Yaksi, Nathalie ; Schmidt, Florian I. ; Wachten, Dagmar:
Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium.
In: eLife. Bd. 9 (2020) . - e57907.
DOI: https://doi.org/10.7554/eLife.57907

Balbach, Melanie ; Fushimi, Makoto ; Huggins, David J. ; Steegborn, Clemens ; Meinke, Peter T. ; Levin, Lonny R. ; Buck, Jochen:
Optimization of lead compounds into on-demand, nonhormonal contraceptives : leveraging a public-private drug discovery institute collaboration.
In: Biology of Reproduction. Bd. 103 (2020) Heft 2 . - S. 176-182.
DOI: https://doi.org/10.1093/biolre/ioaa052

Pilsl, Sebastian ; Morgan, Charles ; Choukeife, Moujab ; Möglich, Andreas ; Mayer, Günter:
Optoribogenetic control of regulatory RNA molecules.
In: Nature Communications. Bd. 11 (2020) Heft 1 . - No. 4825.
DOI: https://doi.org/10.1038/s41467-020-18673-5

Tomaselli, Daniela ; Steegborn, Clemens ; Mai, Antonello ; Rotili, Dante:
Sirt4 : A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer.
In: Frontiers in Oncology. Bd. 10 (2020) . - 474.
DOI: https://doi.org/10.3389/fonc.2020.00474

Teodoro, João S. ; Amorim, João Alves ; Machado, Ivo F. ; Castela, Ana C. ; Steegborn, Clemens ; Sinclair, David A. ; Rolo, Anabel P. ; Palmeira, Carlos M.:
The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function.
In: International Journal of Molecular Sciences. Bd. 21 (2020) Heft 14 . - 4896.
DOI: https://doi.org/10.3390/ijms21144896

You, Weijie ; Steegborn, Clemens:
Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin.
In: ACS Medicinal Chemistry Letters. Bd. 11 (2020) Heft 11 . - S. 2285-2289.
DOI: https://doi.org/10.1021/acsmedchemlett.0c00407

Linke, Heiner ; Höcker, Birte ; Furuta, Ken'ya ; Forde, Nancy R. ; Curmi, Paul M. G.:
Synthetic biology approaches to dissecting linear motor protein function : towards the design and synthesis of artificial autonomous protein walkers.
In: Biophysical Reviews. Bd. 12 (2020) Heft 4 . - S. 1041-1054.
DOI: https://doi.org/10.1007/s12551-020-00717-1

You, Weijie:
Activation and inhibition of Sirt6 by small molecules.
Bayreuth , 2019 . - 120 S.
( Dissertation, 2019 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00004450

Weber, Anna M. ; Kaiser, Jennifer ; Ziegler, Thea ; Pilsl, Sebastian ; Renzl, Christian ; Sixt, Lisa ; Pietruschka, Georg ; Moniot, Sébastien ; Kakoti, Ankana ; Juraschitz, Marc ; Schrottke, Stefanie ; Lledo Bryant, Laura ; Steegborn, Clemens ; Bittl, Robert ; Mayer, Günter ; Möglich, Andreas:
A blue light receptor that mediates RNA binding and translational regulation.
In: Nature Chemical Biology. Bd. 15 (2019) . - S. 1085-1092.
DOI: https://doi.org/10.1038/s41589-019-0346-y

Stüven, Birthe ; Stabel, Robert ; Ohlendorf, Robert ; Beck, Julian ; Schubert, Roman ; Möglich, Andreas:
Characterization and engineering of photoactivated adenylyl cyclases.
In: Biological Chemistry. Bd. 400 (2019) Heft 3 . - S. 429-441.
DOI: https://doi.org/10.1515/hsz-2018-0375

Baumann, Tobias ; Hauf, Matthias ; Richter, Florian ; Albers, Suki ; Möglich, Andreas ; Ignatova, Zoya ; Budisa, Nediljko:
Computational Aminoacyl-tRNA Synthetase Library Design for Photocaged Tyrosine.
In: International Journal of Molecular Sciences. Bd. 20 (2019) Heft 9 . - 2343.
DOI: https://doi.org/10.3390/ijms20092343

Raju, Diana N. ; Hansen, Jan Niklas ; Rassmann, Sebastian ; Stüven, Birthe ; Jikeli, Jan F. ; Strünker, Timo ; Körschen, Heinz G. ; Möglich, Andreas ; Wachten, Dagmar:
Cyclic Nucleotide-Specific Optogenetics Highlights Compartmentalization of the Sperm Flagellum into cAMP Microdomains.
In: Cells. Bd. 8 (2019) Heft 7 . - 648.
DOI: https://doi.org/10.3390/cells8070648

Golonka, David ; Fischbach, Patrick ; Jena, Siddhartha G. ; Kleeberg, Julius R. W. ; Essen, Lars-Oliver ; Toettcher, Jared E. ; Zurbriggen, Matias D. ; Möglich, Andreas:
Deconstructing and repurposing the light-regulated interplay between Arabidopsis phytochromes and interacting factors.
In: Communications Biology. Bd. 2 (2019) . - 448.
DOI: https://doi.org/10.1038/s42003-019-0687-9

Möglich, Andreas ; Janovjak, Harald:
Editorial overview : Synthetic sensors and signals : new tools for a new trade.
In: Current Opinion in Structural Biology. Bd. 57 (2019) . - S. iii-v.
DOI: https://doi.org/10.1016/j.sbi.2019.07.005

Palmeira, Carlos Marques ; Teodoro, João S. ; Amorim, João Alves ; Steegborn, Clemens ; Sinclair, David A. ; Rolo, Anabela Pinto:
Mitohormesis and metabolic health : the interplay between ROS, cAMP and sirtuins.
In: Free Radical Biology and Medicine. Bd. 141 (2019) . - S. 483-491.
DOI: https://doi.org/10.1016/j.freeradbiomed.2019.07.017

Dietler, Julia ; Stabel, Robert ; Möglich, Andreas:
Pulsatile illumination for photobiology and optogenetics.
In: Deiters, Alexander (Hrsg.): Optochemical biology. - Cambridge, MA : Academic Press, 2019 . - S. 227-248 . - (Methods in Enzymology ; 624 )
DOI: https://doi.org/10.1016/bs.mie.2019.04.005

Toledo-Patiño, Saacnicteh ; Chaubey, Manish ; Coles, Murray ; Höcker, Birte:
Reconstructing the Remote Origins of a Fold Singleton from a Flavodoxin-Like Ancestor.
In: Biochemistry. Bd. 58 (2019) Heft 48 . - S. 4790-4793.
DOI: https://doi.org/10.1021/acs.biochem.9b00900

Stabel, Robert ; Stüven, Birthe ; Hansen, Jan Niklas ; Körschen, Heinz G. ; Wachten, Dagmar ; Möglich, Andreas:
Revisiting and Redesigning Light-Activated Cyclic-Mononucleotide Phosphodiesterases.
In: Journal of Molecular Biology. Bd. 431 (2019) Heft 17 . - S. 3029-3045.
DOI: https://doi.org/10.1016/j.jmb.2019.07.011

Möglich, Andreas:
Signal transduction in photoreceptor histidine kinases.
In: Protein Science. Bd. 28 (2019) Heft 11 . - S. 1923-1946.
DOI: https://doi.org/10.1002/pro.3705

You, Weijie ; Zheng, Wei ; Weiß, Sandra ; Chua, Katrin F. ; Steegborn, Clemens:
Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.
In: Scientific Reports. Bd. 9 (2019) . - 19176.
DOI: https://doi.org/10.15495/EPub_UBT_00004703

Wiggins, Shakarr V. ; Steegborn, Clemens ; Levin, Lonny R. ; Buck, Jochen:
Pharmacological modulation of the CO₂/HCO₃⁻/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase.
In: Pharmacology & Therapeutics. Bd. 190 (Oktober 2018) . - S. 173-186.
DOI: https://doi.org/10.1016/j.pharmthera.2018.05.008

Dai, Han ; Sinclair, David A. ; Ellis, James L. ; Steegborn, Clemens:
Sirtuin activators and inhibitors : Promises, achievements, and challenges.
In: Pharmacology & Therapeutics. Bd. 188 (August 2018) . - S. 140-154.
DOI: https://doi.org/10.1016/j.pharmthera.2018.03.004

Pannek, Martin:
Biochemical and structural studies on the mitochondrial Sirtuins 4 and 5.
Bayreuth , 2018 . - 231 S.
( Dissertation, 2018 , Universität Bayreuth, Bayreuther Graduiertenschule für Mathematik und Naturwissenschaften - BayNAT)

Losi, Aba ; Gardner, Kevin H. ; Möglich, Andreas:
Blue-Light Receptors for Optogenetics.
In: Chemical Reviews. Bd. 118 (2018) Heft 21 . - S. 10659-10709.
DOI: https://doi.org/10.1021/acs.chemrev.8b00163

Höcker, Birte ; Winther, Jakob R.:
Editorial overview : A perspective on protein evolution.
In: Current Opinion in Structural Biology. Bd. 48 (2018) . - S. viii-ix.
DOI: https://doi.org/10.1016/j.sbi.2018.01.013

Pinto, Andrea ; El Ali, Zeina ; Moniot, Sébastien ; Tamborini, Lucia ; Steegborn, Clemens ; Foresti, Roberta ; de Micheli, Carlo:
Effects of 3-Bromo-4,5-dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase-1 Expression.
In: ChemistryOpen. Bd. 7 (2018) Heft 11 . - S. 858-864.
DOI: https://doi.org/10.1002/open.201800185

Lichtenstein, Bruce R. ; Höcker, Birte:
Engineering an AB₅ Protein Carrier.
In: Scientific Reports. Bd. 8 (2018) . - 12643.
DOI: https://doi.org/10.1038/s41598-018-30910-y

Möglich, Andreas:
An Open-Source, Cross-Platform Resource for Nonlinear Least-Squares Curve Fitting.
In: Journal of Chemical Education. Bd. 95 (2018) Heft 12 . - S. 2273-2278.
DOI: https://doi.org/10.1021/acs.jchemed.8b00649

Hennemann, Julia ; Iwasaki, Roman S. ; Grund, Tamara N. ; Diensthuber, Ralph P. ; Richter, Florian ; Möglich, Andreas:
Optogenetic Control by Pulsed Illumination.
In: ChemBioChem. Bd. 19 (2018) Heft 12 . - S. 1296-1304.
DOI: https://doi.org/10.1002/cbic.201800030

Lachettini, Sara ; Trisciuoglio, Daniela ; Rotili, Dante ; Lucidi, Alessia ; Salvati, Erica ; Zizza, Pasquale ; di Leo, Luca ; del Bufalo, Donatella ; Ciriolo, Maria Rosa ; Leonetti, Carlo ; Steegborn, Clemens ; Mai, Antonello ; Rizzo, Angela ; Biroccio, Annamaria:
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.
In: Cell Death & Disease. Bd. 9 (2018) . - 996.
DOI: https://doi.org/10.1038/s41419-018-1065-0

Kalbas, Diana ; Liebscher, Sandra ; Nowak, Theresa ; Meleshin, Marat ; Pannek, Martin ; Popp, Corinna ; Alhalabi, Zayan ; Bordusa, Frank ; Sippl, Wolfgang ; Steegborn, Clemens ; Schutkowski, Mike:
Potent and Selective Inhibitors of Human Sirtuin 5.
In: Journal of Medicinal Chemistry. Bd. 61 (2018) Heft 6 . - S. 2460-2471.
DOI: https://doi.org/10.1021/acs.jmedchem.7b01648

Banda-Vázquez, Jesús ; Shanmugaratnam, Sooruban ; Rodríguez-Sotres, Rogelio ; Torres-Larios, Alfredo ; Höcker, Birte ; Sosa-Peinado, Alejandro:
Redesign of LAOBP to bind novel l-amino acid ligands.
In: Protein Science. Bd. 27 (2018) Heft 5 . - S. 957-968.
DOI: https://doi.org/10.1002/pro.3403

Möglich, Andreas:
Signaltransduktion einer lichtregulierten Sensorhistidinkinase.
In: Nachrichten aus der Chemie. Bd. 66 (2018) Heft 2 . - S. 123-126.
DOI: https://doi.org/10.1002/nadc.20184058953

Lechner, Horst ; Ferruz, Noelia ; Höcker, Birte:
Strategies for designing non-natural enzymes and binders.
In: Current Opinion in Chemical Biology. Bd. 47 (2018) . - S. 67-76.
DOI: https://doi.org/10.1016/j.cbpa.2018.07.022

You, Weijie ; Steegborn, Clemens:
Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A : Implications for Protein Deacylase Drug Development.
In: Journal of Medicinal Chemistry. Bd. 61 (2018) Heft 23 . - S. 10922-10928.
DOI: https://doi.org/10.1021/acs.jmedchem.8b01455

Pannek, Martin ; Simic, Zeljko ; Fuszard, Matthew ; Meleshin, Marat ; Rotili, Dante ; Mai, Antonello ; Schutkowski, Mike ; Steegborn, Clemens:
Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features.
In: Nature Communications. Bd. 8 (15 November 2017) . - Article number 1513 (13 Seiten).
DOI: https://doi.org/10.1038/s41467-017-01701-2

Toledo-Patiño, Saacnicteh ; Lobos, Francisco ; Höcker, Birte:
Baukasten der Natur : Neue Proteine aus konservierten Fragmenten.
In: BIOspektrum. Bd. 23 (2017) Heft 6 . - S. 630-633.
DOI: https://doi.org/10.1007/s12268-017-0847-8

Engelhard, Christopher ; Diensthuber, Ralph P. ; Möglich, Andreas ; Bittl, Robert:
Blue-light reception through quaternary transitions.
In: Scientific Reports. Bd. 7 (2017) . - 1385.
DOI: https://doi.org/10.1038/s41598-017-01497-7

Li, Jun ; Bonkowski, Michael S. ; Moniot, Sébastien ; Zhang, Dapeng ; Hubbard, Basil P. ; Ling, Alvin J. Y. ; Rajman, Luis A. ; Qin, Bo ; Lou, Zhenkun ; Gorbunova, Vera ; Aravind, L. ; Steegborn, Clemens ; Sinclair, David A.:
A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.
In: Science. Bd. 355 (2017) Heft 6331 . - S. 1312-1317.
DOI: https://doi.org/10.1126/science.aad8242

de Oliveira, Rita Machado ; Vicente Miranda, Hugo ; Francelle, Laetitia ; Pinho, Raquel ; Szegö, Éva M. ; Martinho, Renato ; Munari, Francesca ; Lázaro, Diana F. ; Moniot, Sébastien ; Guerreiro, Patrícia ; Fonseca-Ornelas, Luis ; Marijanovic, Zrinka ; Antas, Pedro ; Gerhardt, Ellen ; Enguita, Francisco Javier ; Fauvet, Bruno ; Penque, Deborah ; Pais, Teresa Faria ; Tong, Qiang ; Becker, Stefan ; Kügler, Sebastian ; Lashuel, Hilal Ahmed ; Steegborn, Clemens ; Zweckstetter, Markus ; Outeiro, Tiago F.:
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
In: PLoS Biology. Bd. 15 (2017) Heft 4 . - No. e1002601.
DOI: https://doi.org/10.1371/journal.pbio.1002601

Moniot, Sébastien ; Forgione, Mariantonietta ; Lucidi, Alessia ; Hailu, Gebremedhin S. ; Nebbioso, Angela ; Carafa, Vincenzo ; Baratta, Francesca ; Altucci, Lucia ; Giacché, Nicola ; Passeri, Daniela ; Pellicciari, Roberto ; Mai, Antonello ; Steegborn, Clemens ; Rotili, Dante:
Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2 : Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
In: Journal of Medicinal Chemistry. Bd. 60 (2017) Heft 6 . - S. 2344-2360.
DOI: https://doi.org/10.1021/acs.jmedchem.6b01609

Mayer, Günter ; Möglich, Andreas:
Editorial overview: Chemical biotechnology : Interdisciplinary approaches for the engineering of nucleic acids, proteins and cells.
In: Current Opinion in Biotechnology. Bd. 48 (2017) . - S. v-vi.
DOI: https://doi.org/10.1016/j.copbio.2017.08.001

Sterner, Reinhard ; Höcker, Birte ; Kolmar, Harald:
Highlight issue: protein design.
In: Biological Chemistry. Bd. 398 (2017) Heft 1 . - S. 1-2.
DOI: https://doi.org/10.1515/hsz-2016-0322

Quinti, Luisa ; Dayalan Naidu, Sharadha ; Träger, Ulrike ; Chen, Xiqun ; Kegel-Gleason, Kimberly ; Llères, David ; Connolly, Colúm ; Chopra, Vanita ; Low, Cho ; Moniot, Sébastien ; Sapp, Ellen ; Tousley, Adelaide R. ; Vodicka, Petr ; van Kanegan, Michael J. ; Kaltenbach, Linda S. ; Crawford, Lisa A. ; Fuszard, Matthew ; Higgins, Maureen ; Miller, James R. C. ; Farmer, Ruth E. ; Potluri, Vijay ; Samajdar, Susanta ; Meisel, Lisa ; Zhang, Ningzhe ; Snyder, Andrew ; Stein, Ross ; Hersch, Steven M. ; Ellerby, Lisa M. ; Weerapana, Eranthie ; Schwarzschild, Michael A. ; Steegborn, Clemens ; Leavitt, Blair R. ; Degterev, Alexei ; Tabrizi, Sarah J. ; Lo, Donald C. ; DiFiglia, Marian ; Thompson, Leslie M. ; Dinkova-Kostova, Albena T. ; Kazantsev, Aleksey G.:
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 114 (2017) Heft 23 . - S. E4676-E4685.
DOI: https://doi.org/10.1073/pnas.1614943114

Stabel, Robert ; Möglich, Andreas:
Die Kontrolle zyklischer Nukleotide mittels Licht.
In: BIOspektrum. Bd. 23 (2017) Heft 4 . - S. 384-387.
DOI: https://doi.org/10.1007/s12268-017-0813-5

de Oliveira, Rita Machado ; Vicente Miranda, Hugo ; Francelle, Laetitia ; Pinho, Raquel ; Szegö, Éva M. ; Martinho, Renato ; Munari, Francesca ; Lázaro, Diana F. ; Moniot, Sébastien ; Guerreiro, Patrícia ; Fonseca, Luis ; Marijanovic, Zrinka ; Antas, Pedro ; Gerhardt, Ellen ; Enguita, Francisco Javier ; Fauvet, Bruno ; Penque, Deborah ; Pais, Teresa Faria ; Tong, Qiang ; Becker, Stefan ; Kügler, Sebastian ; Lashuel, Hilal Ahmed ; Steegborn, Clemens ; Zweckstetter, Markus ; Outeiro, Tiago F.:
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
In: PLoS Biology. Bd. 15 (2017) Heft 3 . - No. e2000374.
DOI: https://doi.org/10.1371/journal.pbio.2000374

Rajabi, Nima ; Auth, Marina ; Troelsen, Kathrin R. ; Pannek, Martin ; Bhatt, Dhaval ; Fontenas, Martin ; Hirshey, Matthew D. ; Steegborn, Clemens ; Madsen, Andreas S. ; Olsen, Christian Adam:
Mechanism-based Inhibitors of the Human Sirtuin 5 Deacylase : Structure-Activity Relationship, Biostructural, and Kinetic Insight.
In: Angewandte Chemie International Edition. Bd. 56 (2017) Heft 47 . - S. 14836-14841.
DOI: https://doi.org/10.1002/anie.201709050

Nack, Jennifer ; Möglich, Andreas:
Optische Kontrolle zellulärer Prozesse.
In: Nachrichten aus der Chemie. Bd. 65 (2017) Heft 3 . - S. 309-313.
DOI: https://doi.org/10.1002/nadc.20174060764

Hauf, Matthias ; Richter, Florian ; Schneider, Tobias ; Faidt, Thomas ; Martins, Berta M. ; Baumann, Tobias ; Durkin, Patrick ; Dobbek, Holger ; Jacobs, Karin ; Möglich, Andreas ; Budisa, Nediljko:
Photoactivatable mussel-based underwater adhesive proteins by an expanded genetic code.
In: ChemBioChem. Bd. 18 (2017) Heft 18 . - S. 1819-1823.
DOI: https://doi.org/10.1002/cbic.201700327

Stabel, Robert ; Stüven, Birthe ; Ohlendorf, Robert ; Möglich, Andreas:
Primer-Aided Truncation for the Creation of Hybrid Proteins.
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Hawley, Robert G ; Hawley, Teresa S ; He, Congcong ; He, Cynthia Y ; He, Fengtian ; He, Gu ; He, Rong-Rong ; He, Xian-Hui ; He, You-Wen ; He, Yu-Ying ; Heath, Joan K ; Hébert, Marie-Josée ; Heinzen, Robert A ; Helgason, Gudmundur Vignir ; Hensel, Michael ; Henske, Elizabeth P ; Her, Chengtao ; Herman, Paul K ; Hernández, Agustín ; Hernandez, Carlos ; Hernández-Tiedra, Sonia ; Hetz, Claudio ; Hiesinger, P Robin ; Higaki, Katsumi ; Hilfiker, Sabine ; Hill, Bradford G ; Hill, Joseph A ; Hill, William D ; Hino, Keisuke ; Hofius, Daniel ; Hofman, Paul ; Höglinger, Günter U ; Höhfeld, Jörg ; Holz, Marina K ; Hong, Yonggeun ; Hood, David A ; Hoozemans, Jeroen Jm ; Hoppe, Thorsten ; Hsu, Chin ; Hsu, Chin-Yuan ; Hsu, Li-Chung ; Hu, Dong ; Hu, Guochang ; Hu, Hong-Ming ; Hu, Hongbo ; Hu, Ming Chang ; Hu, Yu-Chen ; Hu, Zhuo-Wei ; Hua, Fang ; Hua, Ya ; Huang, Canhua ; Huang, Huey-Lan ; Huang, Kuo-How ; Huang, Kuo-Yang ; Huang, Shile ; Huang, Shiqian ; Huang, Wei-Pang ; Huang, Yi-Ran ; Huang, Yong ; Huang, Yunfei ; Huber, Tobias B ; Huebbe, Patricia ; Huh, Won-Ki ; Hulmi, Juha J ; Hur, Gang Min ; Hurley, James H ; Husak, Zvenyslava ; Hussain, Sabah Na ; Hussain, Salik ; Hwang, Jung Jin ; Hwang, Seungmin ; Hwang, Thomas Is ; Ichihara, Atsuhiro ; Imai, Yuzuru ; Imbriano, Carol ; Inomata, Megumi ; Into, Takeshi ; Iovane, Valentina ; Iovanna, Juan L ; Iozzo, Renato V ; Ip, Nancy Y ; Irazoqui, Javier E ; Iribarren, Pablo ; Isaka, Yoshitaka ; Isakovic, Aleksandra J ; Ischiropoulos, Harry ; Isenberg, Jeffrey S ; Ishaq, Mohammad ; Ishida, Hiroyuki ; Ishii, Isao ; Ishmael, Jane E ; Isidoro, Ciro ; Isobe, Ken-Ichi ; Isono, Erika ; Issazadeh-Navikas, Shohreh ; Itahana, Koji ; Itakura, Eisuke ; Ivanov, Andrei I ; Iyer, Anand Krishnan V ; Izquierdo, José M ; Izumi, Yotaro ; Izzo, Valentina ; Jäättelä, Marja ; Jaber, Nadia ; Jackson, Daniel John ; Jackson, William T ; Jacob, Tony George ; Jacques, Thomas S ; Jagannath, Chinnaswamy ; Jain, Ashish ; Jana, Nihar Ranjan ; Jang, Byoung Kuk ; Jani, Alkesh ; Janji, Bassam ; Jannig, Paulo Roberto ; Jansson, Patric J ; Jean, Steve ; Jendrach, Marina ; Jeon, Ju-Hong ; Jessen, Niels ; Jeung, Eui-Bae ; Jia, Kailiang ; Jia, Lijun ; Jiang, Hong ; Jiang, Hongchi ; Jiang, Liwen ; Jiang, Teng ; Jiang, Xiaoyan ; Jiang, Xuejun ; Jiang, Xuejun ; Jiang, Ying ; Jiang, Yongjun ; Jiménez, Alberto ; Jin, Cheng ; Jin, Hongchuan ; Jin, Lei ; Jin, Meiyan ; Jin, Shengkan ; Jinwal, Umesh Kumar ; Jo, Eun-Kyeong ; Johansen, Terje ; Johnson, Daniel E ; Johnson, Gail Vw ; Johnson, James D ; Jonasch, Eric ; Jones, Chris ; Joosten, Leo Ab ; Jordan, Joaquin ; Joseph, Anna-Maria ; Joseph, Bertrand ; Joubert, Annie M ; Ju, Dianwen ; Ju, Jingfang ; Juan, Hsueh-Fen ; Juenemann, Katrin ; Juhász, Gábor ; Jung, Hye Seung ; Jung, Jae U ; Jung, Yong-Keun ; Jungbluth, Heinz ; Justice, Matthew J ; Jutten, Barry ; Kaakoush, Nadeem O ; Kaarniranta, Kai ; Kaasik, Allen ; Kabuta, Tomohiro ; Kaeffer, Bertrand ; Kågedal, Katarina ; Kahana, Alon ; Kajimura, Shingo ; Kakhlon, Or ; Kalia, Manjula ; Kalvakolanu, Dhan V ; Kamada, Yoshiaki ; Kambas, Konstantinos ; Kaminskyy, Vitaliy O ; Kampinga, Harm H ; Kandouz, Mustapha ; Kang, Chanhee ; Kang, Rui ; Kang, Tae-Cheon ; Kanki, Tomotake ; Kanneganti, Thirumala-Devi ; Kanno, Haruo ; Kanthasamy, Anumantha G ; Kantorow, Marc ; Kaparakis-Liaskos, Maria ; Kapuy, Orsolya ; Karantza, Vassiliki ; Karim, Md Razaul ; Karmakar, Parimal ; Kaser, Arthur ; Kaushik, Susmita ; Kawula, Thomas ; Kaynar, A Murat ; Ke, Po-Yuan ; Ke, Zun-Ji ; Kehrl, John H ; Keller, Kate E ; Kemper, Jongsook Kim ; Kenworthy, Anne K ; Kepp, Oliver ; Kern, Andreas ; Kesari, Santosh ; Kessel, David ; Ketteler, Robin ; Kettelhut, Isis do Carmo ; Khambu, Bilon ; Khan, Muzamil Majid ; Khandelwal, Vinoth Km ; Khare, Sangeeta ; Kiang, Juliann G ; Kiger, Amy A ; Kihara, Akio ; Kim, Arianna L ; Kim, Cheol Hyeon ; Kim, Deok Ryong ; Kim, Do-Hyung ; Kim, Eung Kweon ; Kim, Hye Young ; Kim, Hyung-Ryong ; Kim, Jae-Sung ; Kim, Jeong Hun ; Kim, Jin Cheon ; Kim, Jin Hyoung ; Kim, Kwang Woon ; Kim, Michael D ; Kim, Moon-Moo ; Kim, Peter K ; Kim, Seong Who ; Kim, Soo-Youl ; Kim, Yong-Sun ; Kim, Yonghyun ; Kimchi, Adi ; Kimmelman, Alec C ; Kimura, Tomonori ; King, Jason S ; Kirkegaard, Karla ; Kirkin, Vladimir ; Kirshenbaum, Lorrie A ; Kishi, Shuji ; Kitajima, Yasuo ; Kitamoto, Katsuhiko ; Kitaoka, Yasushi ; Kitazato, Kaio ; Kley, Rudolf A ; Klimecki, Walter T ; Klinkenberg, Michael ; Klucken, Jochen ; Knævelsrud, Helene ; Knecht, Erwin ; Knuppertz, Laura ; Ko, Jiunn-Liang ; Kobayashi, Satoru ; Koch, Jan C ; Koechlin-Ramonatxo, Christelle ; Koenig, Ulrich ; Koh, Young Ho ; Köhler, Katja ; Kohlwein, Sepp D ; Koike, Masato ; Komatsu, Masaaki ; Kominami, Eiki ; Kong, Dexin ; Kong, Hee Jeong ; Konstantakou, Eumorphia G ; Kopp, Benjamin T ; Korcsmaros, Tamas ; Korhonen, Laura ; Korolchuk, Viktor I ; Koshkina, Nadya V ; Kou, Yanjun ; Koukourakis, Michael I ; Koumenis, Constantinos ; Kovács, Attila L ; Kovács, Tibor ; Kovacs, Werner J ; Koya, Daisuke ; Kraft, Claudine ; Krainc, Dimitri ; Kramer, Helmut ; Kravic-Stevovic, Tamara ; Krek, Wilhelm ; Kretz-Remy, Carole ; Krick, Roswitha ; Krishnamurthy, Malathi ; Kriston-Vizi, Janos ; Kroemer, Guido ; Kruer, Michael C ; Kruger, Rejko ; Ktistakis, Nicholas T ; Kuchitsu, Kazuyuki ; Kuhn, Christian ; Kumar, Addanki Pratap ; Kumar, Anuj ; Kumar, Ashok ; Kumar, Deepak ; Kumar, Dhiraj ; Kumar, Rakesh ; Kumar, Sharad ; Kundu, Mondira ; Kung, Hsing-Jien ; Kuno, Atsushi ; Kuo, Sheng-Han ; Kuret, Jeff ; Kurz, Tino ; Kwok, Terry ; Kwon, Taeg Kyu ; Kwon, Yong Tae ; Kyrmizi, Irene ; La Spada, Albert R ; Lafont, Frank ; Lahm, Tim ; Lakkaraju, Aparna ; Lam, Truong ; Lamark, Trond ; Lancel, Steve ; Landowski, Terry H ; Lane, Darius Jr ; Lane, Jon D ; Lanzi, Cinzia ; Lapaquette, Pierre ; Lapierre, Louis R ; Laporte, Jocelyn ; Laukkarinen, Johanna ; Laurie, Gordon W ; Lavandero, Sergio ; Lavie, Lena ; LaVoie, Matthew J ; Law, Betty Yuen Kwan ; Law, Helen Ka-Wai ; Law, Kelsey B ; Layfield, Robert ; Lazo, Pedro A ; Le Cam, Laurent ; Le Roch, Karine G ; Le Stunff, Hervé ; Leardkamolkarn, Vijittra ; Lecuit, Marc ; Lee, Byung-Hoon ; Lee, Che-Hsin ; Lee, Erinna F ; Lee, Gyun Min ; Lee, He-Jin ; Lee, Hsinyu ; Lee, Jae Keun ; Lee, Jongdae ; Lee, Ju-Hyun ; Lee, Jun Hee ; Lee, Michael ; Lee, Myung-Shik ; Lee, Patty J ; Lee, Sam W ; Lee, Seung-Jae ; Lee, Shiow-Ju ; Lee, Stella Y ; Lee, Sug Hyung ; Lee, Sung Sik ; Lee, Sung-Joon ; Lee, Sunhee ; Lee, Ying-Ray ; Lee, Yong J ; Lee, Young H ; Leeuwenburgh, Christiaan ; Lefort, Sylvain ; Legouis, Renaud ; Lei, Jinzhi ; Lei, Qun-Ying ; Leib, David A ; Leibowitz, Gil ; Lekli, Istvan ; Lemaire, Stéphane D ; Lemasters, John J ; Lemberg, Marius K ; Lemoine, Antoinette ; Leng, Shuilong ; Lenz, Guido ; Lenzi, Paola ; Lerman, Lilach O ; Lettieri Barbato, Daniele ; Leu, Julia I-Ju ; Leung, Hing Y ; Levine, Beth ; Lewis, Patrick A ; Lezoualc'h, Frank ; Li, Chi ; Li, Faqiang ; Li, Feng-Jun ; Li, Jun ; Li, Ke ; Li, Lian ; Li, Min ; Li, Min ; Li, Qiang ; Li, Rui ; Li, Sheng ; Li, Wei ; Li, Wei ; Li, Xiaotao ; Li, Yumin ; Lian, Jiqin ; Liang, Chengyu ; Liang, Qiangrong ; Liao, Yulin ; Liberal, Joana ; Liberski, Pawel P ; Lie, Pearl ; Lieberman, Andrew P ; Lim, Hyunjung Jade ; Lim, Kah-Leong ; Lim, Kyu ; Lima, Raquel T ; Lin, Chang-Shen ; Lin, Chiou-Feng ; Lin, Fang ; Lin, Fangming ; Lin, Fu-Cheng ; Lin, Kui ; Lin, Kwang-Huei ; Lin, Pei-Hui ; Lin, Tianwei ; Lin, Wan-Wan ; Lin, Yee-Shin ; Lin, Yong ; Linden, Rafael ; Lindholm, Dan ; Lindqvist, Lisa M ; Lingor, Paul ; Linkermann, Andreas ; Liotta, Lance A ; Lipinski, Marta M ; Lira, Vitor A ; Lisanti, Michael P ; Liton, Paloma B ; Liu, Bo ; Liu, Chong ; Liu, Chun-Feng ; Liu, Fei ; Liu, Hung-Jen ; Liu, Jianxun ; Liu, Jing-Jing ; Liu, Jing-Lan ; Liu, Ke ; Liu, Leyuan ; Liu, Liang ; Liu, Quentin ; Liu, Rong-Yu ; Liu, Shiming ; Liu, Shuwen ; Liu, Wei ; Liu, Xian-De ; Liu, Xiangguo ; Liu, Xiao-Hong ; Liu, Xinfeng ; Liu, Xu ; Liu, Xueqin ; Liu, Yang ; Liu, Yule ; Liu, Zexian ; Liu, Zhe ; Liuzzi, Juan P ; Lizard, Gérard ; Ljujic, Mila ; Lodhi, Irfan J ; Logue, Susan E ; Lokeshwar, Bal L ; Long, Yun Chau ; Lonial, Sagar ; Loos, Benjamin ; López-Otín, Carlos ; López-Vicario, Cristina ; Lorente, Mar ; Lorenzi, Philip L ; Lõrincz, Péter ; Los, Marek ; Lotze, Michael T ; Lovat, Penny E ; Lu, Binfeng ; Lu, Bo ; Lu, Jiahong ; Lu, Qing ; Lu, She-Min ; Lu, Shuyan ; Lu, Yingying ; Luciano, Frédéric ; Luckhart, Shirley ; Lucocq, John Milton ; Ludovico, Paula ; Lugea, Aurelia ; Lukacs, Nicholas W ; Lum, Julian J ; Lund, Anders H ; Luo, Honglin ; Luo, Jia ; Luo, Shouqing ; Luparello, Claudio ; Lyons, Timothy ; Ma, Jianjie ; Ma, Yi ; Ma, Yong ; Ma, Zhenyi ; Machado, Juliano ; Machado-Santelli, Glaucia M ; Macian, Fernando ; MacIntosh, Gustavo C ; MacKeigan, Jeffrey P ; Macleod, Kay F ; MacMicking, John D ; MacMillan-Crow, Lee Ann ; Madeo, Frank ; Madesh, Muniswamy ; Madrigal-Matute, Julio ; Maeda, Akiko ; Maeda, Tatsuya ; Maegawa, Gustavo ; Maellaro, Emilia ; Maes, Hannelore ; Magariños, Marta ; Maiese, Kenneth ; Maiti, Tapas K ; Maiuri, Luigi ; Maiuri, Maria Chiara ; Maki, Carl G ; Malli, Roland ; Malorni, Walter ; Maloyan, Alina ; Mami-Chouaib, Fathia ; Man, Na ; Mancias, Joseph D ; Mandelkow, Eva-Maria ; Mandell, Michael A ; Manfredi, Angelo A ; Manié, Serge N ; Manzoni, Claudia ; Mao, Kai ; Mao, Zixu ; Mao, Zong-Wan ; Marambaud, Philippe ; Marconi, Anna Maria ; Marelja, Zvonimir ; Marfe, Gabriella ; Margeta, Marta ; Margittai, Eva ; Mari, Muriel ; Mariani, Francesca V ; Marin, Concepcio ; Marinelli, Sara ; Mariño, Guillermo ; Markovic, Ivanka ; Marquez, Rebecca ; Martelli, Alberto M ; Martens, Sascha ; Martin, Katie R ; Martin, Seamus J ; Martin, Shaun ; Martin-Acebes, Miguel A ; Martín-Sanz, Paloma ; Martinand-Mari, Camille ; Martinet, Wim ; Martinez, Jennifer ; Martinez-Lopez, Nuria ; Martinez-Outschoorn, Ubaldo ; Martínez-Velázquez, Moisés ; Martinez-Vicente, Marta ; Martins, Waleska Kerllen ; Mashima, Hirosato ; Mastrianni, James A ; Matarese, Giuseppe ; Matarrese, Paola ; Mateo, Roberto ; Matoba, Satoaki ; Matsumoto, Naomichi ; Matsushita, Takehiko ; Matsuura, Akira ; Matsuzawa, Takeshi ; Mattson, Mark P ; Matus, Soledad ; Maugeri, Norma ; Mauvezin, Caroline ; Mayer, Andreas ; Maysinger, Dusica ; Mazzolini, Guillermo D ; McBrayer, Mary Kate ; McCall, Kimberly ; McCormick, Craig ; McInerney, Gerald M ; McIver, Skye C ; McKenna, Sharon ; McMahon, John J ; McNeish, Iain A ; Mechta-Grigoriou, Fatima ; Medema, Jan Paul ; Medina, Diego L ; Megyeri, Klara ; Mehrpour, Maryam ; Mehta, Jawahar L ; Mei, Yide ; Meier, Ute-Christiane ; Meijer, Alfred J ; Meléndez, Alicia ; Melino, Gerry ; Melino, Sonia ; de Melo, Edesio Jose Tenorio ; Mena, Maria A ; Meneghini, Marc D ; Menendez, Javier A ; Menezes, Regina ; Meng, Liesu ; Meng, Ling-Hua ; Meng, Songshu ; Menghini, Rossella ; Menko, A Sue ; Menna-Barreto, Rubem Fs ; Menon, Manoj B ; Meraz-Ríos, Marco A ; Merla, Giuseppe ; Merlini, Luciano ; Merlot, Angelica M ; Meryk, Andreas ; Meschini, Stefania ; Meyer, Joel N ; Mi, Man-Tian ; Miao, Chao-Yu ; Micale, Lucia ; Michaeli, Simon ; Michiels, Carine ; Migliaccio, Anna Rita ; Mihailidou, Anastasia Susie ; Mijaljica, Dalibor ; Mikoshiba, Katsuhiko ; Milan, Enrico ; Miller-Fleming, Leonor ; Mills, Gordon B ; Mills, Ian G ; Minakaki, Georgia ; Minassian, Berge A ; Ming, Xiu-Fen ; Minibayeva, Farida ; Minina, Elena A ; Mintern, Justine D ; Minucci, Saverio ; Miranda-Vizuete, Antonio ; Mitchell, Claire H ; Miyamoto, Shigeki ; Miyazawa, Keisuke ; Mizushima, Noboru ; Mnich, Katarzyna ; Mograbi, Baharia ; Mohseni, Simin ; Moita, Luis Ferreira ; Molinari, Marco ; Molinari, Maurizio ; Møller, Andreas Buch ; Mollereau, Bertrand ; Mollinedo, Faustino ; Mongillo, Marco ; Monick, Martha M ; Montagnaro, Serena ; Montell, Craig ; Moore, Darren J ; Moore, Michael N ; Mora-Rodriguez, Rodrigo ; Moreira, Paula I ; Morel, Etienne ; Morelli, Maria Beatrice ; Moreno, Sandra ; Morgan, Michael J ; Moris, Arnaud ; Moriyasu, Yuji ; Morrison, Janna L ; Morrison, Lynda A ; Morselli, Eugenia ; Moscat, Jorge ; Moseley, Pope L ; Mostowy, Serge ; Motori, Elisa ; Mottet, Denis ; Mottram, Jeremy C ; Moussa, Charbel E-H ; Mpakou, Vassiliki E ; Mukhtar, Hasan ; Mulcahy Levy, Jean M ; Muller, Sylviane ; Muñoz-Moreno, Raquel ; Muñoz-Pinedo, Cristina ; Münz, Christian ; Murphy, Maureen E ; Murray, James T ; Murthy, Aditya ; Mysorekar, Indira U ; Nabi, Ivan R ; Nabissi, Massimo ; Nader, Gustavo A ; Nagahara, Yukitoshi ; Nagai, Yoshitaka ; Nagata, Kazuhiro ; Nagelkerke, Anika ; Nagy, Péter ; Naidu, Samisubbu R ; Nair, Sreejayan ; Nakano, Hiroyasu ; Nakatogawa, Hitoshi ; Nanjundan, Meera ; Napolitano, Gennaro ; Naqvi, Naweed I ; Nardacci, Roberta ; Narendra, Derek P ; Narita, Masashi ; Nascimbeni, Anna Chiara ; Natarajan, Ramesh ; Navegantes, Luiz C ; Nawrocki, Steffan T ; Nazarko, Taras Y ; Nazarko, Volodymyr Y ; Neill, Thomas ; Neri, Luca M ; Netea, Mihai G ; Netea-Maier, Romana T ; Neves, Bruno M ; Ney, Paul A ; Nezis, Ioannis P ; Nguyen, Hang Tt ; Nguyen, Huu Phuc ; Nicot, Anne-Sophie ; Nilsen, Hilde ; Nilsson, Per ; Nishimura, Mikio ; Nishino, Ichizo ; Niso-Santano, Mireia ; Niu, Hua ; Nixon, Ralph A ; Njar, Vincent Co ; Noda, Takeshi ; Noegel, Angelika A ; Nolte, Elsie Magdalena ; Norberg, Erik ; Norga, Koenraad K ; Noureini, Sakineh Kazemi ; Notomi, Shoji ; Notterpek, Lucia ; Nowikovsky, Karin ; Nukina, Nobuyuki ; Nürnberger, Thorsten ; O'Donnell, Valerie B ; O'Donovan, Tracey ; O'Dwyer, Peter J ; Oehme, Ina ; Oeste, Clara L ; Ogawa, Michinaga ; Ogretmen, Besim ; Ogura, Yuji ; Oh, Young J ; Ohmuraya, Masaki ; Ohshima, Takayuki ; Ojha, Rani ; Okamoto, Koji ; Okazaki, Toshiro ; Oliver, F Javier ; Ollinger, Karin ; Olsson, Stefan ; Orban, Daniel P ; Ordonez, Paulina ; Orhon, Idil ; Orosz, Laszlo ; O'Rourke, Eyleen J ; Orozco, Helena ; Ortega, Angel L ; Ortona, Elena ; Osellame, Laura D ; Oshima, Junko ; Oshima, Shigeru ; Osiewacz, Heinz D ; Otomo, Takanobu ; Otsu, Kinya ; Ou, Jing-Hsiung James ; Outeiro, Tiago F ; Ouyang, Dong-Yun ; Ouyang, Hongjiao ; Overholtzer, Michael ; Ozbun, Michelle A ; Ozdinler, P Hande ; Ozpolat, Bulent ; Pacelli, Consiglia ; Paganetti, Paolo ; Page, Guylène ; Pages, Gilles ; Pagnini, Ugo ; Pajak, Beata ; Pak, Stephen C ; Pakos-Zebrucka, Karolina ; Pakpour, Nazzy ; Palková, Zdena ; Palladino, Francesca ; Pallauf, Kathrin ; Pallet, Nicolas ; Palmieri, Marta ; Paludan, Søren R ; Palumbo, Camilla ; Palumbo, Silvia ; Pampliega, Olatz ; Pan, Hongming ; Pan, Wei ; Panaretakis, Theocharis ; Pandey, Aseem ; Pantazopoulou, Areti ; Papackova, Zuzana ; Papademetrio, Daniela L ; Papassideri, Issidora ; Papini, Alessio ; Parajuli, Nirmala ; Pardo, Julian ; Parekh, Vrajesh V ; Parenti, Giancarlo ; Park, Jong-In ; Park, Junsoo ; Park, Ohkmae K ; Parker, Roy ; Parlato, Rosanna ; Parys, Jan B ; Parzych, Katherine R ; Pasquet, Jean-Max ; Pasquier, Benoit ; Pasumarthi, Kishore Bs ; Patschan, Daniel ; Patterson, Cam ; Pattingre, Sophie ; Pattison, Scott ; Pause, Arnim ; Pavenstädt, Hermann ; Pavone, Flaminia ; Pedrozo, Zully ; Peña, Fernando J ; Peñalva, Miguel A ; Pende, Mario ; Peng, Jianxin ; Penna, Fabio ; Penninger, Josef M ; Pensalfini, Anna ; Pepe, Salvatore ; Pereira, Gustavo Js ; Pereira, Paulo C ; Pérez-de la Cruz, Verónica ; Pérez-Pérez, María Esther ; Pérez-Rodríguez, Diego ; Pérez-Sala, Dolores ; Perier, Celine ; Perl, Andras ; Perlmutter, David H ; Perrotta, Ida ; Pervaiz, Shazib ; Pesonen, Maija ; Pessin, Jeffrey E ; Peters, Godefridus J ; Petersen, Morten ; Petrache, Irina ; Petrof, Basil J ; Petrovski, Goran ; Phang, James M ; Piacentini, Mauro ; Pierdominici, Marina ; Pierre, Philippe ; Pierrefite-Carle, Valérie ; Pietrocola, Federico ; Pimentel-Muiños, Felipe X ; Pinar, Mario ; Pineda, Benjamin ; Pinkas-Kramarski, Ronit ; Pinti, Marcello ; Pinton, Paolo ; Piperdi, Bilal ; Piret, James M ; Platanias, Leonidas C ; Platta, Harald W ; Plowey, Edward D ; Pöggeler, Stefanie ; Poirot, Marc ; Polčic, Peter ; Poletti, Angelo ; Poon, Audrey H ; Popelka, Hana ; Popova, Blagovesta ; Poprawa, Izabela ; Poulose, Shibu M ; Poulton, Joanna ; Powers, Scott K ; Powers, Ted ; Pozuelo-Rubio, Mercedes ; Prak, Krisna ; Prange, Reinhild ; Prescott, Mark ; Priault, Muriel ; Prince, Sharon ; Proia, Richard L ; Proikas-Cezanne, Tassula ; Prokisch, Holger ; Promponas, Vasilis J ; Przyklenk, Karin ; Puertollano, Rosa ; Pugazhenthi, Subbiah ; Puglielli, Luigi ; Pujol, Aurora ; Puyal, Julien ; Pyeon, Dohun ; Qi, Xin ; Qian, Wen-Bin ; Qin, Zheng-Hong ; Qiu, Yu ; Qu, Ziwei ; Quadrilatero, Joe ; Quinn, Frederick ; Raben, Nina ; Rabinowich, Hannah ; Radogna, Flavia ; Ragusa, Michael J ; Rahmani, Mohamed ; Raina, Komal ; Ramanadham, Sasanka ; Ramesh, Rajagopal ; Rami, Abdelhaq ; Randall-Demllo, Sarron ; Randow, Felix ; Rao, Hai ; Rao, V Ashutosh ; Rasmussen, Blake B ; Rasse, Tobias M ; Ratovitski, Edward A ; Rautou, Pierre-Emmanuel ; Ray, Swapan K ; Razani, Babak ; Reed, Bruce H ; Reggiori, Fulvio ; Rehm, Markus ; Reichert, Andreas S ; Rein, Theo ; Reiner, David J ; Reits, Eric ; Ren, Jun ; Ren, Xingcong ; Renna, Maurizio ; Reusch, Jane Eb ; Revuelta, Jose L ; Reyes, Leticia ; Rezaie, Alireza R ; Richards, Robert I ; Richardson, Des R ; 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Ohlendorf, Robert ; Schumacher, Charlotte Helene ; Richter, Florian ; Möglich, Andreas:
Library-Aided Probing of Linker Determinants in Hybrid Photoreceptors.
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Stiel, André C. ; Nellen, Mehdi ; Höcker, Birte:
PocketOptimizer and the Design of Ligand Binding Sites.
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Suenkel, Benjamin ; Steegborn, Clemens:
Recombinant Preparation, Biochemical Analysis, and Structure Determination of Sirtuin Family Histone/Protein Deacylases.
In: Marmorstein, Ronen (Hrsg.): Enzymes of epigenetics. Part A. - Cambridge, MA : Academic Press, 2016 . - S. 183-208 . - (Methods in Enzymology ; 573 )
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Quinti, Luisa ; Casale, Malcolm ; Moniot, Sébastien ; Pais, Teresa Faria ; van Kanegan, Michael J. ; Kaltenbach, Linda S. ; Pallos, Judit ; Lim, Ryan G. ; Naidu, Sharadha Dayalan ; Runne, Heike ; Meisel, Lisa ; Rauf, Nazifa Abdul ; Leyfer, Dmitriy ; Maxwell, Michelle M. ; Saiah, Eddine ; Landers, John E. ; Luthi-Carter, Ruth ; Abagyan, Ruben ; Dinkova-Kostova, Albena T. ; Steegborn, Clemens ; Marsh, J. Lawrence ; Lo, Donald C. ; Thompson, Leslie M. ; Kazantsev, Aleksey G.:
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.
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Gertz, Melanie ; Steegborn, Clemens:
Using mitochondrial sirtuins as drug targets : disease implications and available compounds.
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Yee, Estelle F. ; Diensthuber, Ralph P. ; Vaidya, Anand T. ; Borbat, Peter P. ; Engelhard, Christopher ; Freed, Jack H,. ; Bittl, Robert ; Möglich, Andreas ; Crane, Brian R.:
Signal transduction in light-oxygen-voltage receptors lacking the adduct-forming cysteine residue.
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Simic, Zeljko ; Weiwad, Matthias ; Schierhorn, Angelika ; Steegborn, Clemens ; Schutkowski, Mike:
The ɛ-Amino Group of Protein Lysine Residues Is Highly Susceptible to Nonenzymatic Acylation by Several Physiological Acyl-CoA Thioesters.
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di Fruscia, Paolo ; Zacharioudakis, Emmanouil ; Liu, Chang ; Moniot, Sébastien ; Laohasinnarong, Sasiwan ; Khongkow, Mattaka ; Harrison, Ian F. ; Koltsida, Konstantina ; Reynolds, Christopher R. ; Schmidtkunz, Karin ; Jung, Manfred ; Chapman, Kathryn L. ; Steegborn, Clemens ; Dexter, David T. ; Sternberg, Michael J. E. ; Lam, Eric W.-F. ; Fuchter, Matthew J.:
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.
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Schweizer, Ulrich ; Steegborn, Clemens:
New insights into the structure and mechanism of iodothyronine deiodinases.
In: Journal of Molecular Endocrinology. Bd. 55 (2015) Heft 3 . - R37-R52.
DOI: https://doi.org/10.1530/JME-15-0156

Roessler, Claudia ; Tüting, Christian ; Meleshin, Marat ; Steegborn, Clemens ; Schutkowski, Mike:
A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases.
In: Journal of Medicinal Chemistry. Bd. 58 (2015) Heft 18 . - S. 7217-7223.
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Ziegler, Thea ; Möglich, Andreas:
Photoreceptor engineering.
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DOI: https://doi.org/10.3389/fmolb.2015.00030

Fränzel, Benjamin ; Fischer, Frank ; Steegborn, Clemens ; Wolters, Dirk:
Proteinase K improves quantitative acylation studies.
In: Proteomics. Bd. 15 (2015) Heft 1 . - S. 44-47.
DOI: https://doi.org/10.1002/pmic.201400015

Rumpf, Tobias ; Schiedel, Matthias ; Karaman, Berin ; Roessler, Claudia ; North, Brian J. ; Lehotzky, Attila ; Oláh, Judit ; Ladwein, Kathrin I. ; Schmidtkunz, Karin ; Gajer, Markus ; Pannek, Martin ; Steegborn, Clemens ; Sinclair, David A. ; Gerhardt, Stefan ; Ovádi, Judit ; Schutkowski, Mike ; Sippl, Wolfgang ; Einsle, Oliver ; Jung, Manfred:
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
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Chen, Xiqun ; Wales, Pauline ; Quinti, Luisa ; Zuo, Fuxing ; Moniot, Sébastien ; Herisson, Fanny ; Rauf, Nazifa Abdul ; Wang, Hua ; Silverman, Richard B. ; Ayata, Cenk ; Maxwell, Michelle M. ; Steegborn, Clemens ; Schwarzschild, Michael A. ; Outeiro, Tiago F. ; Kazantsev, Aleksey G.:
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
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Richter, Florian ; Scheib, Ulrike ; Mehlhorn, Jennifer ; Schubert, Roman ; Wietek, Jonas ; Gernetzki, Oliver ; Hegemann, Peter ; Mathes, Tilo ; Möglich, Andreas:
Upgrading a microplate reader for photobiology and all-optical experiments.
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Polletta, Lucia ; Vernucci, Enza ; Carnevale, Ilaria ; Arcangeli, Tania ; Rotili, Dante ; Palmerio, Silvia ; Steegborn, Clemens ; Nowak, Theresa ; Schutkowski, Mike ; Pellegrini, Laura ; Sansone, Luigi ; Villanova, Lidia ; Runci, Alessandra ; Pucci, Bruna ; Morgante, Emanuela ; Fini, Massimo ; Mai, Antonello ; Russo, Matteo A. ; Tafani, Marco:
SIRT5 regulation of ammonia-induced autophagy and mitophagy.
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Schweizer, Ulrich ; Steegborn, Clemens:
Thyroid hormones : From Crystal Packing to Activity to Reactivity.
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Banerjee, Arka ; Adolph, Ramona S. ; Gopalakrishnapai, Jayashree ; Kleinbölting, Silke ; Emmerich, Christiane ; Steegborn, Clemens ; Visweswariah, Sandhya S.:
A Universal Stress Protein (USP) in Mycobacteria binds cAMP.
In: The Journal of Biological Chemistry. Bd. 290 (2015) Heft 20 . - S. 12731-12743.
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Kleinbölting, Silke:
Strukturelle und biochemische Charakterisierung der humanen löslichen Adenylyl-Cyclase.
Bayreuth , 2014 . - VII, 135 S.
( Dissertation, 2014 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)

Schutkowski, Mike ; Fischer, Frank ; Roessler, Claudia ; Steegborn, Clemens:
New assays and approaches for discovery and design of Sirtuin modulators.
In: Expert Opinion on Drug Discovery. Bd. 9 (Februar 2014) Heft 2 . - S. 183-199.
DOI: https://doi.org/10.1517/17460441.2014.875526

Nguyen, Giang Thi Tuyet:
Regulation of Mitochondrial Sirtuins Sirt3 and Sirt5 by Small Molecules.
Bayreuth , 2014 . - IX, 92 S.
( Dissertation, 2014 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)

Diensthuber, Ralph P. ; Engelhard, Christopher ; Lemke, Nora ; Gleichmann, Tobias ; Ohlendorf, Robert ; Bittl, Robert ; Möglich, Andreas:
Biophysical, mutational, and functional investigation of the chromophore-binding pocket of light-oxygen-voltage photoreceptors.
In: ACS Synthetic Biology. Bd. 3 (2014) Heft 11 . - S. 811-819.
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Scheib, Ulrike ; Shanmugaratnam, Sooruban ; Farías-Rico, José Arcadio ; Höcker, Birte:
Change in protein-ligand specificity through binding pocket grafting.
In: Journal of Structural Biology. Bd. 185 (2014) Heft 2 . - S. 186-192.
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Maier, Raimund:
Charakterisierung modularer Peptidyl-Prolyl-cis-trans-Isomerasen.
Bayreuth , 2014 . - 153 S.
( Dissertation, 2014 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)

Schweizer, Ulrich ; Schlicker, Christine ; Braun, Doreen ; Köhrle, Josef ; Steegborn, Clemens:
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 111 (2014) Heft 29 . - S. 10526-10531.
DOI: https://doi.org/10.1073/pnas.1323873111

Kleinbölting, Silke ; Diaz, Ana ; Moniot, Sébastien ; van den Heuvel, Joop ; Weyand, Michael ; Levin, Lonny R. ; Buck, Jochen ; Steegborn, Clemens:
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 111 (2014) Heft 10 . - S. 3727-3732.
DOI: https://doi.org/10.1073/pnas.1322778111

Suhre, Michael H. ; Scheibel, Thomas ; Steegborn, Clemens ; Gertz, Melanie:
Crystallization and preliminary X-ray diffractionanalysis of proximal thread matrix protein 1(PTMP1) from Mytilus galloprovincialis.
In: Acta Crystallographica Section F. Bd. 70 (2014) Heft 6 . - S. 769-772.
DOI: https://doi.org/10.1107/S2053230X14006165

Höcker, Birte:
Design of proteins from smaller fragments : learning from evolution.
In: Current Opinion in Structural Biology. Bd. 27 (2014) . - S. 56-62.
DOI: https://doi.org/10.1016/j.sbi.2014.04.007

Höcker, Birte ; Midelfort, Katarina:
Designing protein function : macromolecular design.
In: Journal of Structural Biology. Bd. 185 (2014) Heft 2 . - S. 135.
DOI: https://doi.org/10.1016/j.jsb.2014.01.011

Gasser, Carlos ; Taiber, Sandra ; Yeh, Chen-Min ; Wittig, Charlotte Helene ; Hegemann, Peter ; Ryu, Soojin ; Wunder, Frank ; Möglich, Andreas:
Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 111 (2014) Heft 24 . - S. 8803-8808.
DOI: https://doi.org/10.1073/pnas.1321600111

Farías-Rico, José Arcadio ; Schmidt, Steffen ; Höcker, Birte:
Evolutionary relationship of two ancient protein superfolds.
In: Nature Chemical Biology. Bd. 10 (2014) Heft 9 . - S. 710-715.
DOI: https://doi.org/10.1038/nchembio.1579

Kleinbölting, Silke ; van den Heuvel, Joop ; Kambach, Christian ; Weyand, Michael ; Leipelt, Martina ; Steegborn, Clemens:
Expression, purification, crystallization and preliminary X-ray diffraction analysis of a mammalian type 10 adenylyl cyclase.
In: Acta Crystallographica Section F. Bd. 70 (2014) Heft 4 . - S. 467-469.
DOI: https://doi.org/10.1107/S2053230X14004014

Stiel, André C. ; Feldmeier, Kaspar ; Höcker, Birte:
Identification of protein scaffolds for enzyme design using scaffold selection.
In: Köhler, Valentin (Hrsg.): Protein design : methods and applications. 2nd Edition. - New York, NY : Humana Press, 2014 . - S. 183-196 . - (Methods in Molecular Biology ; 1216 )
DOI: https://doi.org/10.1007/978-1-4939-1486-9_9

Kleinbölting, Silke ; van den Heuvel, Joop ; Steegborn, Clemens:
Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide complexes-implications for cyclase catalysis and evolution.
In: The FEBS Journal. Bd. 281 (2014) Heft 18 . - S. 4151-4164.
DOI: https://doi.org/10.1111/febs.12913

Suhre, Michael H. ; Gertz, Melanie ; Steegborn, Clemens ; Scheibel, Thomas:
Structural and functional features of a collagen-binding matrix protein from the mussel byssus.
In: Nature Communications. Bd. 5 (2014) . - 3392.
DOI: https://doi.org/10.1038/ncomms4392

Steegborn, Clemens:
Structure, mechanism, and regulation of soluble adenylyl cyclases : similarities and differences to transmembrane adenylyl cyclases.
In: Biochimica et Biophysica Acta : Molecular Basis of Disease. Bd. 1842 (2014) Heft 12, Part B . - S. 2535-2547.
DOI: https://doi.org/10.1016/j.bbadis.2014.08.012

Roessler, Claudia ; Nowak, Theresa ; Pannek, Martin ; Gertz, Melanie ; Nguyen, Giang Thi Tuyet ; Scharfe, Michael ; Born, Ilona ; Sippl, Wolfgang ; Steegborn, Clemens ; Schutkowski, Mike:
Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors.
In: Angewandte Chemie International Edition. Bd. 53 (2014) Heft 40 . - S. 10728-10732.
DOI: https://doi.org/10.1002/anie.201402679

Möglich, Andreas ; Hegemann, Peter:
Biotechnology : Programming genomes with light.
In: Nature. Bd. 500 (22 August 2013) Heft 7463 . - S. 406-408.
DOI: https://doi.org/10.1038/500406a

Laurent, Gaëlle ; German, Natalie J. ; Saha, Asish K. ; de Boer, Vincent C. J. ; Davies, Michael ; Koves, Timothy R. ; Dephoure, Noah ; Fischer, Frank ; Boanca, Gina ; Vaitheesvaran, Bhavapriya ; Lovitch, Scott B. ; Sharpe, Arlene H. ; Kurland, Irwin J. ; Steegborn, Clemens ; Gygi, Steven P. ; Muoio, Deborah M. ; Ruderman, Neil B. ; Haigis, Marcia C.:
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
In: Molecular Cell. Bd. 50 (6 Juni 2013) Heft 5 . - S. 686-698.
DOI: https://doi.org/10.1016/j.molcel.2013.05.012

Rauh, David ; Fischer, Frank ; Gertz, Melanie ; Lakshminarasimhan, Mahadevan ; Bergbrede, Tim ; Aladini, Firouzeh ; Kambach, Christian ; Becker, Christian F. W. ; Zerweck, Johannes ; Schutkowski, Mike ; Steegborn, Clemens:
An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms.
In: Nature Communications. Bd. 4 (2013) . - S. 2327.
DOI: https://doi.org/10.1038/ncomms3327

Moffat, Keith ; Zhang, Feng ; Hahn, Klaus ; Möglich, Andreas:
The Biophysics and Engineering of Signaling Photoreceptors.
In: Hegemann, Peter ; Sigrist, Stephan (Hrsg.): Optogenetics. - Berlin : De Gruyter, 2013 . - S. 7-20

Gleichmann, Tobias ; Diensthuber, Ralph P. ; Möglich, Andreas:
Charting the signal trajectory in a light-oxygen-voltage photoreceptor by random mutagenesis and covariance analysis.
In: The Journal of Biological Chemistry. Bd. 288 (2013) Heft 41 . - S. 29345-29355.
DOI: https://doi.org/10.1074/jbc.M113.506139

Feldmeier, Kaspar ; Höcker, Birte:
Computational protein design of ligand binding and catalysis.
In: Current Opinion in Chemical Biology. Bd. 17 (2013) Heft 6 . - S. 929-933.
DOI: https://doi.org/10.1016/j.cbpa.2013.10.002

Moniot, Sébastien ; Schutkowski, Mike ; Steegborn, Clemens:
Crystal structure analysis of human Sirt2 and its ADP-ribose complex.
In: Journal of Structural Biology. Bd. 182 (2013) Heft 2 . - S. 136-143.
DOI: https://doi.org/10.1016/j.jsb.2013.02.012

Nguyen, Giang Thi Tuyet ; Gertz, Melanie ; Steegborn, Clemens:
Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism.
In: Chemistry & Biology. Bd. 20 (2013) Heft 11 . - S. 1375-1385.
DOI: https://doi.org/10.1016/j.chembiol.2013.09.019

Rockwell, Nathan C. ; Ohlendorf, Robert ; Möglich, Andreas:
Cyanobacteriochromes in full color and three dimensions.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 110 (2013) Heft 3 . - S. 806-807.
DOI: https://doi.org/10.1073/pnas.1220690110

Farías-Rico, José Arcadio ; Höcker, Birte:
Design of chimeric proteins by combination of subdomain-sized fragments.
In: Keating, Amy E. (Hrsg.): Methods in protein design. - Amsterdam [u.a.] : Academic Press, 2013 . - S. 389-405 . - (Methods in Enzymology ; 523 )
DOI: https://doi.org/10.1016/B978-0-12-394292-0.00018-7

Höcker, Birte:
Engineering chimaeric proteins from fold fragments : "hopeful monsters" in protein design.
In: Biochemical Society Transactions. Bd. 41 (2013) Heft 5 . - S. 1137-1140.
DOI: https://doi.org/10.1042/BST20130099

Gertz, Melanie ; Fischer, Frank ; Nguyen, Giang Thi Tuyet ; Lakshminarasimhan, Mahadevan ; Schutkowski, Mike ; Weyand, Michael ; Steegborn, Clemens:
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 110 (2013) Heft 30 . - S. E2772-E2781.
DOI: https://doi.org/10.1073/pnas.1303628110

Diensthuber, Ralph P. ; Bommer, Martin ; Gleichmann, Tobias ; Möglich, Andreas:
Full-length structure of a sensor histidine kinase pinpoints coaxial coiled coils as signal transducers and modulators.
In: Structure. Bd. 21 (2013) Heft 7 . - S. 1127-1136.
DOI: https://doi.org/10.1016/j.str.2013.04.024

Suenkel, Benjamin ; Fischer, Frank ; Steegborn, Clemens:
Inhibition of the human deacylase Sirtuin 5 by the indole GW5074.
In: Bioorganic & Medicinal Chemistry Letters. Bd. 23 (2013) Heft 1 . - S. 143-146.
DOI: https://doi.org/10.1016/j.bmcl.2012.10.136

Diensthuber, Ralph P. ; Ohlendorf, Robert ; Gleichmann, Tobias ; Möglich, Andreas:
Lichtregulierte Genexpression.
In: BIOspektrum. Bd. 19 (2013) Heft 2 . - S. 149-151.
DOI: https://doi.org/10.1007/s12268-013-0286-0

Lakshminarasimhan, Mahadevan ; Curth, Ute ; Moniot, Sébastien ; Mosalaganti, Shyamal ; Raunser, Stefan ; Steegborn, Clemens:
Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol.
In: Bioscience Reports. Bd. 33 (2013) Heft 3 . - S. 395-404.
DOI: https://doi.org/10.1042/BSR20120121

Meier, Monika M. ; Rajendran, Chitra ; Malisi, Christoph ; Fox, Nicholas G. ; Xu, Chengfu ; Schlee, Sandra ; Barondeau, David P. ; Höcker, Birte ; Sterner, Reinhard ; Raushel, Frank M.:
Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template.
In: Journal of the American Chemical Society. Bd. 135 (2013) Heft 31 . - S. 11670-11677.
DOI: https://doi.org/10.1021/ja405911h

Lakshminarasimhan, Mahadevan ; Rauh, David ; Schutkowski, Mike ; Steegborn, Clemens:
Sirt1 activation by resveratrol is substrate sequence-selective.
In: Aging. Bd. 5 (2013) Heft 3 . - S. 151-154.

Engelhard, Christopher ; Raffelberg, Sarah ; Tang, Yifen ; Diensthuber, Ralph P. ; Möglich, Andreas ; Losi, Aba ; Gärtner, Wolfgang ; Bittl, Robert:
A structural model for the full-length blue light-sensing protein YtvA from Bacillus subtilis, based on EPR spectroscopy.
In: Photochemical & Photobiological Sciences. Bd. 12 (2013) Heft 10 . - S. 1855-1863.
DOI: https://doi.org/10.1039/c3pp50128k

Nguyen, Giang Thi Tuyet ; Schäfer, Susanne ; Gertz, Melanie ; Weyand, Michael ; Steegborn, Clemens:
Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism.
In: Acta Crystallographica Section D. Bd. 69 (2013) Heft 8 . - S. 1423-1432.
DOI: https://doi.org/10.1107/S0907444913015448

Malisi, Christoph ; Schumann, Marcel ; Toussaint, Nora C ; Kageyama, Jorge ; Kohlbacher, Oliver ; Höcker, Birte:
Binding pocket optimization by computational protein design.
In: PLoS One. Bd. 7 (2012) Heft 12 . - No. e52505.
DOI: https://doi.org/10.1371/journal.pone.0052505

Topal, Hüsnü ; Fulcher, Nanette B. ; Bitterman, Jacob ; Salazar, Eric ; Buck, Jochen ; Levin, Lonny R. ; Cann, Martin J. ; Wolfgang, Matthew C. ; Steegborn, Clemens:
Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa.
In: Journal of Molecular Biology. Bd. 416 (2012) Heft 2 . - S. 271-286.
DOI: https://doi.org/10.1016/j.jmb.2011.12.045

Ohlendorf, Robert ; Vidavski, Roee R. ; Eldar, Avigdor ; Moffat, Keith ; Möglich, Andreas:
From dusk till dawn : one-plasmid systems for light-regulated gene expression.
In: Journal of Molecular Biology. Bd. 416 (2012) Heft 4 . - S. 534-542.
DOI: https://doi.org/10.1016/j.jmb.2012.01.001

Shanmugaratnam, Sooruban ; Eisenbeis, Simone ; Höcker, Birte:
A highly stable protein chimera built from fragments of different folds.
In: Protein Engineering, Design & Selection. Bd. 25 (2012) Heft 11 . - S. 699-703.
DOI: https://doi.org/10.1093/protein/gzs074

Middelhaufe, Sabine ; Leipelt, Martina ; Levin, Lonny R. ; Buck, Jochen ; Steegborn, Clemens:
Identification of a haem domain in human soluble adenylate cyclase.
In: Bioscience Reports. Bd. 32 (2012) Heft 5 . - S. 491-499.
DOI: https://doi.org/10.1042/BSR20120051

Gertz, Melanie ; Nguyen, Giang Thi Tuyet ; Fischer, Frank ; Suenkel, Benjamin ; Schlicker, Christine ; Fränzel, Benjamin ; Tomaschewski, Jana ; Aladini, Firouzeh ; Becker, Christian F. W. ; Wolters, Dirk ; Steegborn, Clemens:
A molecular mechanism for direct sirtuin activation by resveratrol.
In: PLoS One. Bd. 7 (2012) Heft 11 . - No. e49761.
DOI: https://doi.org/10.1371/journal.pone.0049761

Eisenbeis, Simone ; Proffitt, William ; Coles, Murray ; Truffault, Vincent ; Shanmugaratnam, Sooruban ; Meiler, Jens ; Höcker, Birte:
Potential of fragment recombination for rational design of proteins.
In: Journal of the American Chemical Society. Bd. 134 (2012) Heft 9 . - S. 4019-4022.
DOI: https://doi.org/10.1021/ja211657k

Höcker, Birte:
Protein design : A metalloenzyme reloaded.
In: Nature Chemical Biology. Bd. 8 (2012) Heft 3 . - S. 224-225.
DOI: https://doi.org/10.1038/nchembio.800

Fischer, Frank ; Gertz, Melanie ; Suenkel, Benjamin ; Lakshminarasimhan, Mahadevan ; Schutkowski, Mike ; Steegborn, Clemens:
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.
In: PLoS One. Bd. 7 (2012) Heft 9 . - No. e45098.
DOI: https://doi.org/10.1371/journal.pone.0045098

Höcker, Birte:
Structural biology : A toolbox for protein design.
In: Nature. Bd. 491 (2012) Heft 7423 . - S. 204-205.
DOI: https://doi.org/10.1038/491204a

Moniot, Sébastien ; Weyand, Michael ; Steegborn, Clemens:
Structures, substrates, and regulators of Mammalian sirtuins : opportunities and challenges for drug development.
In: Frontiers in Pharmacology. Bd. 3 (2012) . - 16.
DOI: https://doi.org/10.3389/fphar.2012.00016

Hegemann, Peter ; Möglich, Andreas:
Channelrhodopsin engineering and exploration of new optogenetic tools.
In: Nature Methods. Bd. 8 (Januar 2011) Heft 1 . - S. 39-42.
DOI: https://doi.org/10.1038/nmeth.f.327

Russwurm, Michael ; Schlicker, Christine ; Weyand, Michael ; Koesling, Doris ; Steegborn, Clemens:
Crystal structure of the GAF-B domain from human phosphodiesterase 5.
In: Proteins. Bd. 79 (2011) Heft 5 . - S. 1682-1687.
DOI: https://doi.org/10.1002/prot.22989

Lakshminarasimhan, Mahadevan ; Steegborn, Clemens:
Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets.
In: Experimental Gerontology. Bd. 46 (2011) Heft 2-3 . - S. 174-177.
DOI: https://doi.org/10.1016/j.exger.2010.08.024

Malisi, Christoph ; Stiel, André C. ; Höcker, Birte:
Enzyme am Reißbrett.
In: BIOspektrum. Bd. 17 (2011) Heft 7 . - S. 736-738.
DOI: https://doi.org/10.1007/s12268-011-0117-0

Synatschke, Christopher V. ; Schallon, Anja ; Jérôme, Valérie ; Freitag, Ruth ; Müller, Axel H. E.:
Influence of Polymer Architecture and Molecular Weight of Poly(2-(dimethylamino)ethyl methacrylate) Polycations on Transfection Efficiency and Cell Viability in Gene Delivery.
In: Biomacromolecules. Bd. 12 (2011) Heft 12 . - S. 4247-4255.
DOI: https://doi.org/10.1021/bm201111d

Schlicker, Christine ; Boanca, Gina ; Lakshminarasimhan, Mahadevan ; Steegborn, Clemens:
Structure-based development of novel sirtuin inhibitors.
In: Aging. Bd. 3 (2011) Heft 9 . - S. 852-872.

Acin-Perez, Rebeca ; Russwurm, Michael ; Günnewig, Kathrin ; Gertz, Melanie ; Zoidl, Georg ; Ramos, Lavoisier ; Buck, Jochen ; Levin, Lonny R. ; Rassow, Joachim ; Manfredi, Giovanni ; Steegborn, Clemens:
A phosphodiesterase 2A isoform localized to mitochondria regulates respiration.
In: The Journal of Biological Chemistry. Bd. 286 (2011) Heft 35 . - S. 30423-30432.
DOI: https://doi.org/10.1074/jbc.M111.266379

Möglich, Andreas ; Ayers, Rebecca A. ; Moffat, Keith:
Addition at the molecular level : signal integration in designed Per-ARNT-Sim receptor proteins.
In: Journal of Molecular Biology. Bd. 400 (2010) Heft 3 . - S. 477-486.
DOI: https://doi.org/10.1016/j.jmb.2010.05.019

Hall, Rebecca A. ; de Sordi, Luisa ; Maccallum, Donna M. ; Topal, Hüsnü ; Eaton, Rebecca ; Bloor, James W. ; Robinson, Gary K. ; Levin, Lonny R. ; Buck, Jochen ; Wang, Yue ; Gow, Neil A .R. ; Steegborn, Clemens ; Mühlschlegel, Fritz A.:
CO₂ acts as a signalling molecule in populations of the fungal pathogen Candida albicans.
In: PLoS Pathogens. Bd. 6 (2010) Heft 11 . - No. e1001193.
DOI: https://doi.org/10.1371/journal.ppat.1001193

Baur, Joseph A. ; Chen, Danica ; Chini, Eduardo N. ; Chua, Katrin F. ; Cohen, Haim Y. ; de Cabo, Rafael ; Deng, Chuxia ; Dimmeler, Stefanie ; Gius, David ; Guarente, Leonard P. ; Helfand, Stephen L. ; Imai, Shin-Ichiro ; Itoh, Hiroshi ; Kadowaki, Takashi ; Koya, Daisuke ; Leeuwenburgh, Christiaan ; McBurney, Michael ; Nabeshima, Yo-Ichi ; Neri, Christian ; Oberdoerffer, Philipp ; Pestell, Richard G. ; Rogina, Blanka ; Sadoshima, Junichi ; Sartorelli, Vittorio ; Serrano, Manuel ; Sinclair, David A. ; Steegborn, Clemens ; Tatar, Marc ; Tissenbaum, Heidi A. ; Tong, Qiang ; Tsubota, Kazuo ; Vaquero, Alejandro ; Verdin, Eric:
Dietary restriction : standing up for sirtuins.
In: Science. Bd. 329 (2010) Heft 5995 . - S. 1012-1013.
DOI: https://doi.org/10.1126/science.329.5995.1012

Möglich, Andreas ; Moffat, Keith:
Engineered photoreceptors as novel optogenetic tools.
In: Photochemical & Photobiological Sciences. Bd. 9 (2010) Heft 10 . - S. 1286-1300.
DOI: https://doi.org/10.1039/c0pp00167h

Schreier, Bettina ; Höcker, Birte:
Engineering the enolase magnesium II binding site: implications for its evolution.
In: Biochemistry. Bd. 49 (2010) Heft 35 . - S. 7582-7589.
DOI: https://doi.org/10.1021/bi100954f

Eisenbeis, Simone ; Höcker, Birte:
Evolutionary mechanism as a template for protein engineering.
In: Journal of Peptide Science. Bd. 16 (2010) Heft 10 . - S. 538-544.
DOI: https://doi.org/10.1002/psc.1233

Gertz, Melanie ; Steegborn, Clemens:
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.
In: Biochimica et Biophysica Acta : Proteins and Proteomics. Bd. 1804 (2010) Heft 8 . - S. 1658-1665.
DOI: https://doi.org/10.1016/j.bbapap.2009.09.011

Gertz, Melanie ; Steegborn, Clemens:
The Lifespan-Regulator p66Shc in mitochondria : redox enzyme or redox sensor?
In: Antioxidants & Redox Signaling. Bd. 13 (2010) Heft 9 . - S. 1417-1428.
DOI: https://doi.org/10.1089/ars.2010.3147

Höcker, Birte:
Metals make proteins stick.
In: Chemistry & Biology. Bd. 17 (2010) Heft 2 . - S. 103-104.
DOI: https://doi.org/10.1016/j.chembiol.2010.02.002

Gertz, Melanie ; Steegborn, Clemens:
The mitochondrial apoptosis pathway and p66Shc : a regulatory redox enzyme or an adapter protein snuggling around?
In: Cell Cycle. Bd. 9 (2010) Heft 22 . - S. 4425-4426.
DOI: https://doi.org/10.4161/cc.9.22.14053

Möglich, Andreas ; Yang, Xiaojing ; Ayers, Rebecca A. ; Moffat, Keith:
Structure and function of plant photoreceptors.
In: Annual Review of Plant Biology. Bd. 61 (2010) . - S. 21-47.
DOI: https://doi.org/10.1146/annurev-arplant-042809-112259

Malisi, Christoph ; Kohlbacher, Oliver ; Höcker, Birte:
Automated scaffold selection for enzyme design.
In: Proteins. Bd. 77 (2009) Heft 1 . - S. 74-83.
DOI: https://doi.org/10.1002/prot.22418

Innocenti, Alessio ; Hall, Rebecca A. ; Schlicker, Christine ; Scozzafava, Andrea ; Steegborn, Clemens ; Mühlschlegel, Fritz A. ; Supuran, Claudiu T.:
Carbonic anhydrase inhibitors : Inhibition and homology modeling studies of the fungal β-carbonic anhydrase from Candida albicans with sulfonamides.
In: Bioorganic & Medicinal Chemistry. Bd. 17 (2009) Heft 13 . - S. 4503-4509.
DOI: https://doi.org/10.1016/j.bmc.2009.05.002

Schreier, Bettina ; Stumpp, Christian ; Wiesner, Silke ; Höcker, Birte:
Computational design of ligand binding is not a solved problem.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 106 (2009) Heft 44 . - S. 18491-18496.
DOI: https://doi.org/10.1073/pnas.0907950106

Steegborn, Clemens ; Ohndorf, Uta-Maria ; Schlicker, Christine:
Crystallographic studies on carbonic anhydrases from fungal pathogens for structure-assisted drug development.
In: Supuran, Claudiu T. ; Winum, J.-Y. (Hrsg.): Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural and Disease Applications. - Hoboken, NJ : Wiley, 2009 . - S. 323-334 . - (Wiley Series in Drug Discovery and Development )

Möglich, Andreas ; Ayers, Rebecca A. ; Moffat, Keith:
Design and signaling mechanism of light-regulated histidine kinases.
In: Journal of Molecular Biology. Bd. 385 (2009) Heft 5 . - S. 1433-1444.
DOI: https://doi.org/10.1016/j.jmb.2008.12.017

Claren, Jörg ; Malisi, Christoph ; Höcker, Birte ; Sterner, Reinhard:
Establishing wild-type levels of catalytic activity on natural and artificial (βα)8-barrel protein scaffolds.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 106 (2009) Heft 10 . - S. 3704-3709.
DOI: https://doi.org/10.1073/pnas.0810342106

Höcker, Birte ; Lochner, Adriane ; Seitz, Tobias ; Claren, Jörg ; Sterner, Reinhard:
High-resolution crystal structure of an artificial (βα)₈-barrel protein designed from identical half-barrels.
In: Biochemistry. Bd. 48 (2009) Heft 6 . - S. 1145-1147.
DOI: https://doi.org/10.1021/bi802125b

Gertz, Melanie ; Fischer, Frank ; Leipelt, Martina ; Wolters, Dirk ; Steegborn, Clemens:
Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc.
In: Aging. Bd. 1 (2009) Heft 2 . - S. 254-265.

Schlicker, Christine ; Hall, Rebecca A. ; Vullo, Daniela ; Middelhaufe, Sabine ; Gertz, Melanie ; Supuran, Claudiu T. ; Mühlschlegel, Fritz A. ; Steegborn, Clemens:
Structure and inhibition of the CO₂-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans.
In: Journal of Molecular Biology. Bd. 385 (2009) Heft 4 . - S. 1207-1220.
DOI: https://doi.org/10.1016/j.jmb.2008.11.037

Möglich, Andreas ; Ayers, Rebecca A. ; Moffat, Keith:
Structure and signaling mechanism of Per-ARNT-Sim domains.
In: Structure. Bd. 17 (2009) Heft 10 . - S. 1282-1294.
DOI: https://doi.org/10.1016/j.str.2009.08.011

Gertz, Melanie ; Fischer, Frank ; Wolters, Dirk ; Steegborn, Clemens:
Activation of the lifespan regulator p66Shc through reversible disulfide bond formation.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 105 (2008) Heft 15 . - S. 5705-5709.
DOI: https://doi.org/10.1073/pnas.0800691105

Bharat, Tanmay A. M. ; Eisenbeis, Simone ; Zeth, Kornelius ; Höcker, Birte:
A βα-barrel built by the combination of fragments from different folds.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 105 (2008) Heft 29 . - S. 9942-9947.
DOI: https://doi.org/10.1073/pnas.0802202105

Innocenti, Alessio ; Mühlschlegel, Fritz A. ; Hall, Rebecca A. ; Steegborn, Clemens ; Scozzafava, Andrea ; Supuran, Claudiu T.:
Carbonic anhydrase inhibitors: inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.
In: Bioorganic & Medicinal Chemistry Letters. Bd. 18 (2008) Heft 18 . - S. 5066-5070.
DOI: https://doi.org/10.1016/j.bmcl.2008.07.122

Rauch, Annika ; Leipelt, Martina ; Russwurm, Michael ; Steegborn, Clemens:
Crystal structure of the guanylyl cyclase Cya2.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 105 (2008) Heft 41 . - S. 15720-15725.
DOI: https://doi.org/10.1073/pnas.0808473105

Tammenkoski, Marko ; Koivula, Katja ; Cusanelli, Emilio ; Zollo, Massimo ; Steegborn, Clemens ; Baykov, Alexander A. ; Lahti, Reijo:
Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase.
In: Biochemistry. Bd. 47 (2008) Heft 36 . - S. 9707-9713.
DOI: https://doi.org/10.1021/bi8010847

Garzia, Livia ; D'Angelo, A. ; Amoresano, A. ; Knauer, Shirley K. ; Cirulli, C. ; Campanella, C. ; Stauber, R. H. ; Steegborn, Clemens ; Iolascon, A. ; Zollo, Massimo:
Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility.
In: Oncogene. Bd. 27 (2008) . - S. 1853-1864.
DOI: https://doi.org/10.1038/sj.onc.1210822

Reetz, Manfred T. ; Rentzsch, Martin ; Pletsch, Andreas ; Taglieber, Andreas ; Hollmann, Frank ; Mondière, Régis J. G. ; Dickmann, Norbert ; Höcker, Birte ; Cerrone, Simona ; Haeger, Michaela C. ; Sterner, Reinhard:
A robust protein host for anchoring chelating ligands and organocatalysts.
In: ChemBioChem. Bd. 9 (2008) Heft 4 . - S. 552-564.
DOI: https://doi.org/10.1002/cbic.200700413

Schlicker, Christine ; Rauch, Annika ; Hess, Ken C. ; Kachholz, Barbara ; Levin, Lonny R. ; Buck, Jochen ; Steegborn, Clemens:
Structure-based development of novel adenylyl cyclase inhibitors.
In: Journal of Medicinal Chemistry. Bd. 51 (2008) Heft 15 . - S. 4456-4464.
DOI: https://doi.org/10.1021/jm800481q

Schlicker, Christine ; Gertz, Melanie ; Papatheodorou, Panagiotis ; Kachholz, Barbara ; Becker, Christian F. W. ; Steegborn, Clemens:
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.
In: Journal of Molecular Biology. Bd. 382 (2008) Heft 3 . - S. 790-801.
DOI: https://doi.org/10.1016/j.jmb.2008.07.048

Middelhaufe, Sabine ; Garzia, Livia ; Ohndorf, Uta-Maria ; Kachholz, Barbara ; Zollo, Massimo ; Steegborn, Clemens:
Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain.
In: Biochemical Journal. Bd. 407 (2007) Heft 2 . - S. 199-205.
DOI: https://doi.org/10.1042/BJ20070408

Mannherz, Hans Georg ; Ballweber, Edda ; Galla, Marco ; Villard, Sylvie ; Granier, Claude ; Steegborn, Clemens ; Schmidtmann, Anja ; Jaquet, Kornelia ; Pope, Brian ; Weeds, Alan G.:
Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array : evidence for a second binding site on monomeric actin.
In: Journal of Molecular Biology. Bd. 366 (2007) Heft 3 . - S. 745-755.
DOI: https://doi.org/10.1016/j.jmb.2006.11.100

Möglich, Andreas ; Moffat, Keith:
Structural basis for light-dependent signaling in the dimeric LOV domain of the photosensor YtvA.
In: Journal of Molecular Biology. Bd. 373 (2007) Heft 1 . - S. 112-126.
DOI: https://doi.org/10.1016/j.jmb.2007.07.039

Mogensen, Estelle Geweiss ; Janbon, Guilhem ; Chaloupka, James ; Steegborn, Clemens ; Fu, Man Shun ; Moyrand, Frédérique ; Klengel, Torsten ; Pearson, David S. ; Geeves, Michael A. ; Buck, Jochen ; Levin, Lonny R. ; Mühlschlegel, Fritz A.:
Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1.
In: Eukaryotic Cell. Bd. 5 (Januar 2006) Heft 1 . - S. 103-111.
DOI: https://doi.org/10.1128/EC.5.1.103-111.2006

Möglich, Andreas ; Joder, Karin ; Kiefhaber, Thomas:
End-to-end distance distributions and intrachain diffusion constants in unfolded polypeptide chains indicate intramolecular hydrogen bond formation.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 103 (2006) Heft 33 . - S. 12394-12399.
DOI: https://doi.org/10.1073/pnas.0604748103

Kamenetsky, Margarita ; Middelhaufe, Sabine ; Bank, Erin M. ; Levin, Lonny R. ; Buck, Jochen ; Steegborn, Clemens:
Molecular details of cAMP generation in mammalian cells : a tale of two systems.
In: Journal of Molecular Biology. Bd. 362 (2006) Heft 4 . - S. 623-639.
DOI: https://doi.org/10.1016/j.jmb.2006.07.045

Steegborn, Clemens ; Litvin, Tatiana N. ; Levin, Lonny R. ; Buck, Jochen ; Wu, Hao:
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment.
In: Nature Structural & Molecular Biology. Bd. 12 (Januar 2005) Heft 1 . - S. 32-37.
DOI: https://doi.org/10.1038/nsmb880

Sterner, Reinhard ; Höcker, Birte:
Catalytic versatility, stability, and evolution of the (betaalpha)8-barrel enzyme fold.
In: Chemical Reviews. Bd. 105 (2005) Heft 11 . - S. 4038-4055.
DOI: https://doi.org/10.1021/cr030191z

Höcker, Birte:
Directed evolution of (βα)₈-barrel enzymes.
In: Biomolecular Engineering. Bd. 22 (2005) Heft 1-3 . - S. 31-38.
DOI: https://doi.org/10.1016/j.bioeng.2004.09.005

Krieger, Florian ; Möglich, Andreas ; Kiefhaber, Thomas:
Effect of proline and glycine residues on dynamics and barriers of loop formation in polypeptide chains.
In: Journal of the American Chemical Society. Bd. 127 (2005) Heft 10 . - S. 3346-3352.
DOI: https://doi.org/10.1021/ja042798i

Möglich, Andreas ; Krieger, Florian ; Kiefhaber, Thomas:
Molecular basis for the effect of urea and guanidinium chloride on the dynamics of unfolded polypeptide chains.
In: Journal of Molecular Biology. Bd. 345 (2005) Heft 1 . - S. 153-162.
DOI: https://doi.org/10.1016/j.jmb.2004.10.036

Möglich, Andreas ; Weinfurtner, Daniel ; Gronwald, Wolfram ; Maurer, Till ; Kalbitzer, Hans Robert:
PERMOL : restraint-based protein homology modeling using DYANA or CNS.
In: Bioinformatics. Bd. 21 (2005) Heft 9 . - S. 2110-2111.
DOI: https://doi.org/10.1093/bioinformatics/bti276

Möglich, Andreas ; Weinfurtner, Daniel ; Maurer, Till ; Gronwald, Wolfram ; Kalbitzer, Hans Robert:
A restraint molecular dynamics and simulated annealing approach for protein homology modeling utilizing mean angles.
In: BMC Bioinformatics. Bd. 6 (2005) . - 91.
DOI: https://doi.org/10.1186/1471-2105-6-91

Steegborn, Clemens ; Litvin, Tatiana N. ; Hess, Kenneth C. ; Capper, Austin B. ; Taussig, Ronald ; Buck, Jochen ; Levin, Lonny R. ; Wu, Hao:
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen.
In: The Journal of Biological Chemistry. Bd. 280 (2005) Heft 36 . - S. 31754-31759.
DOI: https://doi.org/10.1074/jbc.M507144200

Möglich, Andreas ; Koch, Brigitte ; Gronwald, Wolfram ; Hengstenberg, Wolfgang ; Brunner, Eike ; Kalbitzer, Hans Robert:
Solution structure of the active-centre mutant I14A of the histidine-containing phosphocarrier protein from Staphylococcus carnosus.
In: European Journal of Biochemistry. Bd. 271 (Dezember 2004) Heft 23-24 . - S. 4815-4824.
DOI: https://doi.org/10.1111/j.1432-1033.2004.04447.x

Martin, Georges ; Möglich, Andreas ; Keller, Walter ; Doublié, Sylvie:
Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase.
In: Journal of Molecular Biology. Bd. 341 (2004) Heft 4 . - S. 911-925.
DOI: https://doi.org/10.1016/j.jmb.2004.06.047

Ye, Hong ; Chen, Tzu-Chao ; Xu, Xiaohui ; Pennycooke, Micha ; Wu, Hao ; Steegborn, Clemens:
Crystal structure of the putative adapter protein MTH1859.
In: Journal of Structural Biology. Bd. 148 (2004) Heft 2 . - S. 251-256.
DOI: https://doi.org/10.1016/j.jsb.2004.06.004

Güthe, Sarah ; Kapinos, Larisa ; Möglich, Andreas ; Meier, Sebastian ; Grzesiek, Stephan ; Kiefhaber, Thomas:
Very fast folding and association of a trimerization domain from bacteriophage T4 fibritin.
In: Journal of Molecular Biology. Bd. 337 (2004) Heft 4 . - S. 905-915.
DOI: https://doi.org/10.1016/j.jmb.2004.02.020

Augustin, Martin A. ; Reichert, Andreas S. ; Betat, Heike ; Huber, Robert ; Mörl, Mario ; Steegborn, Clemens:
Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization.
In: Journal of Molecular Biology. Bd. 328 (2003) Heft 5 . - S. 985-994.
DOI: https://doi.org/10.1016/S0022-2836(03)00381-4

Messerschmidt, Albrecht ; Worbs, Michael ; Steegborn, Clemens ; Wahl, Markus C. ; Huber, Robert ; Laber, Bernd ; Clausen, Tim:
Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine ɣ-lyase from yeast and intrafamiliar structure comparison.
In: Biological Chemistry. Bd. 384 (2003) Heft 3 . - S. 373-386.
DOI: https://doi.org/10.1515/BC.2003.043

Gröger, Christian ; Möglich, Andreas ; Pons, Miguel ; Koch, Brigitte ; Hengstenberg, Wolfgang ; Kalbitzer, Hans Robert ; Brunner, Eike:
NMR-spectroscopic mapping of an engineered cavity in the I14A mutant of HPr from Staphylococcus carnosus using xenon.
In: Journal of the American Chemical Society. Bd. 125 (2003) Heft 29 . - S. 8726-8727.
DOI: https://doi.org/10.1021/ja030113t

Xu, Guozhou ; Rich, Rebecca L. ; Steegborn, Clemens ; Min, Tongpil ; Huang, Yihua ; Myszka, David G. ; Wu, Hao:
Mutational analyses of the p35-caspase interaction : A bowstring kinetic model of caspase inhibition by p35.
In: The Journal of Biological Chemistry. Bd. 278 (2003) Heft 7 . - S. 5455-5461.
DOI: https://doi.org/10.1074/jbc.M211607200

Stabler, Sally P. ; Steegborn, Clemens ; Wahl, Markus C. ; Oliveriusova, Jana ; Kraus, Jan P. ; Allen, Robert H. ; Wagner, Conrad ; Mudd, S. Harvey:
Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency.
In: Metabolism. Bd. 51 (August 2002) Heft 8 . - S. 981-988.
DOI: https://doi.org/10.1053/meta.2002.34017

Höcker, Birte ; Schmidt, Steffen ; Sterner, Reinhard:
A common evolutionary origin of two elementary enzyme folds.
In: FEBS Letters. Bd. 510 (2002) Heft 3 . - S. 133-135.
DOI: https://doi.org/10.1016/S0014-5793(01)03232-X

Möglich, Andreas ; Wenzler, Michael ; Kramer, Frank ; Glaser, Steffen J. ; Brunner, Eike:
Determination of residual dipolar couplings in homonuclear MOCCA-SIAM experiments.
In: Journal of Biomolecular NMR. Bd. 23 (2002) Heft 3 . - S. 211-219.
DOI: https://doi.org/10.1023/A:1019841602348

Raasch, Carsten ; Armbrecht, Martin ; Streit, Wolfgang R. ; Höcker, Birte ; Sträter, Norbert ; Liebl, Wolfgang:
Identification of residues important for NAD+ binding by the Thermotoga maritima alpha-glucosidase AglA, a member of glycoside hydrolase family 4.
In: FEBS Letters. Bd. 517 (2002) Heft 1-3 . - S. 267-271.
DOI: https://doi.org/10.1016/S0014-5793(02)02641-8

Hey, Thomas:
Das Problem der Erkennung von DNA-Schäden bei der humanen Nukleotid-Exzisions-Reparatur.
Bayreuth , 2002 . - VII, 144 S.
( Dissertation, 2002 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)

Rossoll, Wilfried ; Kröning, Ann-Kathrin ; Ohndorf, Uta-Maria ; Steegborn, Clemens ; Jablonka, Sibylle ; Sendtner, Michael:
Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?
In: Human Molecular Genetics. Bd. 11 (2002) Heft 1 . - S. 93-105.
DOI: https://doi.org/10.1093/hmg/11.1.93

Steegborn, Clemens ; Laber, Bernd ; Messerschmidt, Albrecht ; Huber, Robert ; Clausen, Tim:
Crystal structures of cystathionine γ-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor.
In: Journal of Molecular Biology. Bd. 311 (2001) Heft 4 . - S. 789-801.
DOI: https://doi.org/10.1006/jmbi.2001.4880

Höcker, Birte ; Beismann-Driemeyer, Silke ; Hettwer, Stefan ; Lustig, Ariel ; Sterner, Reinhard:
Dissection of a (betaalpha)8-barrel enzyme into two folded halves.
In: Nature Structural Biology. Bd. 8 (2001) Heft 1 . - S. 32-36.
DOI: https://doi.org/10.1038/83021