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Growth Factors Acting Via Tyrosine Kinase Receptors Induce HSP90a Gene Expression

Title data

Jérôme, Valérie ; Léger, Josette ; Devin, Jocelyne ; Baulieu, Etienne-Emile ; Catelli, Maria-Grazia:
Growth Factors Acting Via Tyrosine Kinase Receptors Induce HSP90a Gene Expression.
In: Growth Factors. Vol. 4 (1 January 1991) Issue 4 . - pp. 317-327.
ISSN 0897-7194
DOI: https://doi.org/10.3109/08977199109043917

Official URL: Volltext

Abstract in another language

Hsp90 is a heat-shock protein constitutively expressed in most cells. Besides regulation by thermal stress, the expression of hsp90 is also positively regulated by developmental and mitogenic stimuli. The effect of serum and insulin on protein and hsp90ar-mRNA levels has been studied in the chicken hepatoma cell line DU249. The culture of cells in serum-free medium resulted in a decrease of hsp90α-mRNA level. A transient increase was observed at 6-9 h after serum restimulation. The expression of hsp90 gene was also increased by insulin alone in a dose-dependent manner and was maximum between 6 and 9 h treatment. The insulin induced increase of hsp90α-mRNA was suppressed by cycloheximide (10μg/ml) but not by an inhibitor of DNA synthesis, demonstrating that this induction requires protein neosynthesis. In serum starved cells, other growth factors (IGFi, EGF and bFGF) showed a positive effect on hsp90α-mRNA level which took place before DNA synthesis with the same time-course as that of insulin. With PDGF, the induction of hsp90α-mRNA occurred earlier. The time interval between the maximum of hsp90α-mRNA induction and that of DNA synthesis was the same for all growth factors studied. From these results, we conclude that growth factors acting via tyrosine kinase receptors up-regulate hsp90α-mRNA level in a DNA synthesis independent manner, possibly in late G₁.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Process Biotechnology
Result of work at the UBT: No
DDC Subjects: 500 Science
500 Science > 500 Natural sciences
500 Science > 570 Life sciences, biology
Date Deposited: 26 Feb 2016 13:14
Last Modified: 26 Feb 2016 13:14
URI: https://eref.uni-bayreuth.de/id/eprint/31093