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Faculties > Faculty of Engineering Science > Chair Process Biotechnology

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Number of items at this level: 121.

2021

Rudolph, Julia ; Völkl, Matthias ; Jérôme, Valérie ; Scheibel, Thomas ; Freitag, Ruth:
Noxic effects of polystyrene microparticles on murine macrophages and epithelial cells.
In: Scientific Reports. Vol. 11 (3 August 2021) Issue 1 .
DOI: https://doi.org/10.1038/s41598-021-95073-9

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Diaz Ariza, Ivonne L. ; Jérôme, Valérie ; Pérez Pérez, León D. ; Freitag, Ruth:
Amphiphilic Graft Copolymers Capable of Mixed-Mode Interaction as Alternative Nonviral Transfection Agents.
In: ACS Applied Bio Materials. Vol. 3 (2021) .
DOI: https://doi.org/10.1021/acsabm.0c01123

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Keim, Daniel ; Gollner, Katrin ; Gollner, Ulrich ; Jérôme, Valérie ; Freitag, Ruth:
Generation of Recombinant Primary Human B Lymphocytes Using Non-Viral Vectors.
In: International Journal of Molecular Sciences. Vol. 22 (2021) Issue 15 . - No. 8239.
DOI: https://doi.org/10.3390/ijms22158239

Helm, Moritz ; Riedl, Simon ; Gollner, K. ; Gollner, U. ; Jérôme, Valérie ; Freitag, Ruth:
Isolation of primary human B lymphocytes from tonsils compared to blood as alternative source for ex vivo application.
In: Journal of Chromatography B. Vol. 1179 (2021) . - No. 122853.
DOI: https://doi.org/10.1016/j.jchromb.2021.122853

2020

Weithmann, Nicolas ; Mlinar, Stanislava ; Sonnleitner, Eva ; Weig, Alfons ; Freitag, Ruth:
Flexible feeding in anaerobic digestion – Impact on process stability, performance and microbial community structures.
In: Anaerobe. (17 November 2020) . - No. 102297.
DOI: https://doi.org/10.1016/j.anaerobe.2020.102297

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Riese, Cornelius N. ; Uebe, René ; Rosenfeldt, Sabine ; Schenk, Anna S. ; Jérôme, Valérie ; Freitag, Ruth ; Schüler, Dirk:
An automated oxystat fermentation regime for microoxic cultivation of Magnetospirillum gryphiswaldense.
In: Microbial Cell Factories. Vol. 19 (10 November 2020) . - No. 206.
DOI: https://doi.org/10.1186/s12934-020-01469-z

Mlinar, Stanislava ; Weig, Alfons R. ; Freitag, Ruth:
Influence of mixing and sludge volume on stability, reproducibility, and productivity of laboratory-scale anaerobic digestion.
In: Bioresource Technology Reports. Vol. 11 (14 May 2020) . - No. 100444.
DOI: https://doi.org/10.1016/j.biteb.2020.100444

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Mickoleit, Frank ; Jérôme, Valérie ; Freitag, Ruth ; Schüler, Dirk:
Bacterial Magnetosomes as Novel Platform for the Presentation of Immunostimulatory, Membrane-Bound Ligands in Cellular Biotechnology.
In: Advanced Biosystems. Vol. 4 (2020) Issue 3 . - No. 1900231.
DOI: https://doi.org/10.1002/adbi.201900231

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Mader, Michael ; Helm, Moritz ; Lu, Mingxia ; Stenzel, Martina H. ; Jérôme, Valérie ; Agarwal, Seema ; Freitag, Ruth ; Greiner, Andreas:
Perfusion Cultivation of Artificial Liver ECM in Fibrous Polymer Sponges Biomimicking Scaffolds for Tissue Engineering.
In: Biomacromolecules. (2020) .
DOI: https://doi.org/10.1021/acs.biomac.0c00900

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Simeon, Meshack I. ; Asoiro, Felix U. ; Aliyu, Mohamad ; Raji, Olayinka A. ; Freitag, Ruth:
Polarization and power density trends of a soil-based microbial fuel cell treated with human urine.
In: International Journal of Energy Research. Vol. 44 (2020) Issue 7 . - pp. 5968-5976.
DOI: https://doi.org/10.15495/EPub_UBT_00005040

Diaz, Ivonne L. ; Sierra, Cesar A. ; Jérôme, Valérie ; Freitag, Ruth ; Perez, León D.:
Target grafting of poly(2-(dimethylamino)ethyl methacrylate) to biodegradable block copolymers.
In: Journal of Polymer Science. Vol. 58 (2020) Issue 16 . - pp. 2168-2180.
DOI: https://doi.org/10.1002/pol.20200204

Rosenfeldt, Sabine ; Mickoleit, Frank ; Jörke, Cornelia ; Clement, Joachim H. ; Markert, Simon ; Jérôme, Valérie ; Schwarzinger, Stephan ; Freitag, Ruth ; Schüler, Dirk ; Uebe, René ; Schenk, Anna:
Towards standardized purification of bacterial magnetic nanoparticles for future in vivo applications.
In: Acta Biomaterialia. (2020) .
DOI: https://doi.org/10.1016/j.actbio.2020.07.042

2019

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Weithmann, Nicolas ; Mlinar, Stanislava ; Hilbrig, Frank ; Bachmaf, Samer ; Arndt, Julia ; Planer-Friedrich, Britta ; Weig, Alfons ; Freitag, Ruth:
Arsenic metabolism in technical biogas plants : possible consequences for resident microbiota and downstream units.
In: AMB Express. Vol. 9 (2019) . - No. 190.
DOI: https://doi.org/10.1186/s13568-019-0902-6

Reich, Steffen ; Kaiser, Patrick ; Mafi, Mahsa ; Schmalz, Holger ; Rhinow, Daniel ; Freitag, Ruth ; Greiner, Andreas:
High‐Temperature Spray‐Dried Polymer/Bacteria Microparticles for Electrospinning of Composite Nonwovens.
In: Macromolecular Bioscience. Vol. 19 (2019) Issue 5 . - p. 1800356.
DOI: https://doi.org/10.1002/mabi.201800356

Jérôme, Valérie ; Freitag, Ruth ; Schüler, Dirk ; Mickoleit, Frank:
SEAP activity measurement in reporter cell-based assays using BCIP / NBT as substrate.
In: Analytical Biochemistry. Vol. 585 (2019) . - No. 113402.
DOI: https://doi.org/10.1016/j.ab.2019.113402

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Stahlschmidt, Ullrich:
Systematische Studie der Transfektion von Säugerzellen mittels PDMAEMA-basierter paramagnetischer Nanosterne.
Bayreuth , 2019 . - 160 p.
( Doctoral thesis, 2019 , Universität Bayreuth, Bayreuther Graduiertenschule für Mathematik und Naturwissenschaften - BayNAT)
DOI: https://doi.org/10.15495/EPub_UBT_00004332

2018

Kaiser, Patrick ; Werner, Melanie ; Jérôme, Valérie ; Freitag, Ruth:
Scale‐up of the ex vivo expansion of encapsulated primary human T lymphocytes.
In: Biotechnology and Bioengineering. (30 June 2018) Issue Early view . - pp. 1-11.
DOI: https://doi.org/10.1002/bit.26786

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Chen, Baizhu ; Synatschke, Christopher V. ; Jérôme, Valérie ; Müller, Axel H. E. ; Freitag, Ruth ; Wu, Chi:
Co-transfection of star-shaped PDMAEMAs enhance transfection efficiency of protamine/pDNA complexes in the presence of serum.
In: European Polymer Journal. (2018) . - 38 S..
DOI: https://doi.org/10.1016/j.eurpolymj.2018.04.022

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Weithmann, Nicolas:
Einfluss von Stressfaktoren auf die Etablierung der prokaryotischen Gemeinschaft und den Metabolismus in biotechnischen, anaeroben Prozessen.
Bayreuth , 2018 . - I-XVII, 132, XVII-LXXIV p.
( Doctoral thesis, 2018 , Universität Bayreuth, Bayreuther Graduiertenschule für Mathematik und Naturwissenschaften - BayNAT)
DOI: https://doi.org/10.15495/EPub_UBT_00004222

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Riedl, Simon ; Kaiser, Patrick ; Raup, Alexander ; Synatschke, Christopher ; Jérôme, Valérie ; Freitag, Ruth:
Non-Viral Transfection of Human T Lymphocytes.
In: Processes. Vol. 6 (2018) Issue 10 . - No. 188.
DOI: https://doi.org/10.3390/pr6100188

Stoppok, Manfred ; Jess, Andreas ; Freitag, Ruth ; Alber, Erdmute:
Of culture, consumption and cost : A comparative Analysis of household energy consumption in Kenya, Germany and Spain.
In: Energy Research & Social Science. Vol. 40 (2018) . - pp. 127-139.
DOI: https://doi.org/10.1016/j.erss.2017.12.004

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Weithmann, Nicolas ; Möller, Julia N. ; Löder, Martin ; Piehl, Sarah ; Laforsch, Christian ; Freitag, Ruth:
Organic fertilizer as a vehicle for the entry of microplastic into the environment.
In: Science Advances. Vol. 4 (2018) Issue 4 .
DOI: https://doi.org/10.1126/sciadv.aap8060

Pretscher, Martin ; Pineda-Contreras, Beatriz A. ; Kaiser, Patrick ; Reich, Steffen ; Schöbel, Judith ; Kuttner, Christian ; Freitag, Ruth ; Fery, Andreas ; Schmalz, Holger ; Agarwal, Seema:
pH-Responsive Biohybrid Carrier Material for Phenol Decontamination in Wastewater.
In: Biomacromolecules. Vol. 19 (2018) Issue 8 . - pp. 3224-3232.
DOI: https://doi.org/10.1021/acs.biomac.8b00361

Kaiser, Patrick ; Reich, Steffen ; Greiner, Andreas ; Freitag, Ruth:
Preparation of Biocomposite Microfibers Ready for Processing into Biologically Active Textile Fabrics for Bioremediation.
In: Macromolecular Bioscience. Vol. 18 (2018) Issue 7 . - Eintrag 1800046.
DOI: https://doi.org/10.1002/mabi.201800046

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Mader, Michael ; Jérôme, Valérie ; Freitag, Ruth ; Agarwal, Seema ; Greiner, Andreas:
Ultraporous, compressible, wettable polylactide/polycaprolactone sponges for tissue engineering.
In: Biomacromolecules. (2018) .
DOI: https://doi.org/10.1021/acs.biomac.8b00434

2017

Raup, Alexander ; Wang, Hui ; Synatschke, Christopher V. ; Jérôme, Valérie ; Agarwal, Seema ; Pergushov, Dmitry V. ; Müller, Axel H. E. ; Freitag, Ruth:
Compaction and transmembrane delivery of pDNA : differences between l-PEI and two types of amphiphilic block copolymers.
In: Biomacromolecules. Vol. 18 (2017) Issue 3 . - pp. 808-818.
DOI: https://doi.org/10.1021/acs.biomac.6b01678

Jérôme, Valérie ; Thoring, Lena ; Salzig, Denise ; Kubick, Stefan ; Freitag, Ruth:
Comparison of cell-based vs. cell-free mammalian systems for the production of a recombinant human bone morphogenic growth factor.
In: Engineering in Life Sciences. (2017) .
DOI: https://doi.org/10.1002/elsc.201700005

Jérôme, Valérie ; Werner, Melanie ; Kaiser, Patrick ; Freitag, Ruth:
Creating a Biomimetic Microenvironment for the Ex Vivo Expansion of Primary Human T Lymphocytes.
In: Macromolecular Bioscience. (2017) .
DOI: https://doi.org/10.1002/mabi.201700091

Kaiser, Patrick ; Reich, Steffen ; Leykam, Daniel ; Willert-Porada, Monika ; Greiner, Andreas ; Freitag, Ruth:
Electrogenic Single-Species Biocomposites as Anodes for Microbial Fuel Cells.
In: Macromolecular Bioscience. (2017) .
DOI: https://doi.org/10.1002/mabi.201600442

Stahlschmidt, Ullrich ; Jérôme, Valérie ; Majewski, Alexander P. ; Müller, Axel H. E. ; Freitag, Ruth:
Systematic Study of a Library of PDMAEMA-Based, Superparamagnetic Nano-Stars for the Transfection of CHO-K1 Cells.
In: Polymers. Vol. 9 (2017) Issue 5 .
DOI: https://doi.org/10.3390/polym9050156

2016

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Raup, Alexander ; Stahlschmidt, Ullrich ; Jérôme, Valérie ; Synatschke, Christopher V. ; Müller, Axel H. E. ; Freitag, Ruth:
Influence of Polyplex Formation on the Performance of Star-Shaped Polycationic Transfection Agents for Mammalian Cells.
Process Biotechnology, University of Bayreuth, 95440 Bayreuth, Germany; Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, 60611 IL, USA; Institute of Organic Chemistry, Johannes-Gutenberg-University, 55099 Mainz, Germany
In: Polymers. Vol. 8 (June 2016) Issue 6 . - p. 224.
DOI: https://doi.org/10.3390/polym8060224

Raup, Alexander ; Jérôme, Valérie ; Freitag, Ruth ; Synatschke, Christopher V. ; Müller, Axel H. E.:
Promoter, transgene, and cell line effects in the transfection of mammalian cells using PDMAEMA-based nano-stars.
In: Biotechnology Reports. Vol. 11 (June 2016) . - pp. 53-61.
DOI: https://doi.org/10.1016/j.btre.2016.05.003

Zambrano, Kenny ; Jérôme, Valérie ; Freitag, Ruth ; Buchholz, Rainer ; Jäck, Hans-Martin ; Hübner, Holger ; Schuh, Wolfgang:
Prolonged Ex vivo expansion and differentiation of naïve murine CD43− B splenocytes.
In: Biotechnology Progress. Vol. 32 (2016) Issue 4 . - pp. 978-989.
DOI: https://doi.org/10.1002/btpr.2265

2015

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Pineda Contreras, Paul ; Kuttner, Christian ; Fery, Andreas ; Stahlschmidt, Ullrich ; Jérôme, Valérie ; Freitag, Ruth ; Agarwal, Seema:
Renaissance for Low Shrinking Resins : all-in-one Solution by Bi-Functional Vinylcyclopropane-Amides.
In: Chemical Communications. Vol. 51 (16 June 2015) Issue 59 . - pp. 11899-11902.
DOI: https://doi.org/10.1039/C5CC03901K

Shi, Yinfeng ; Zhou, Peiran ; Jérôme, Valérie ; Freitag, Ruth ; Agarwal, Seema:
Enzymatically Degradable Polyester-Based Adhesives.
In: ACS Biomaterials Science & Engineering. (2015) .
DOI: https://doi.org/10.1021/acsbiomaterials.5b00217

Werner, Melanie ; Schmoldt, Daria ; Hilbrig, Frank ; Jérôme, Valérie ; Raup, Alexander ; Zambrano, Kenny ; Hübner, Holger ; Buchholz, Rainer ; Freitag, Ruth:
High Cell Density Cultivation of Human Leukemia T Cells (Jurkat Cells) in Semipermeable Polyelectrolyte Microcapsules.
In: Engineering in Life Sciences. Vol. 15 (2015) Issue 4 . - pp. 357-367.
DOI: https://doi.org/10.1002/elsc.201400186

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Käfer, Florian ; Liu, Fangyao ; Stahlschmidt, Ullrich ; Jérôme, Valérie ; Freitag, Ruth ; Karg, Matthias ; Agarwal, Seema:
LCST and UCST in one : Double thermoresponsive behavior of block copolymers of poly(ethylene glycol) and poly(acrylamide-co-acrylonitrile).
University of Bayreuth, Macromolecular Chemistry II and Center for Colloids and Interfaces; University of Bayreuth, Physical Chemistry I; University of Bayreuth, Chair for Process Biotechnology
In: Langmuir. Vol. 31 (2015) Issue 32 . - pp. 8940-8946.
DOI: https://doi.org/10.1021/acs.langmuir.5b02006

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Knierim, Christian ; Enzeroth, Michaela ; Kaiser, Patrick ; Dams, Christian ; Nette, David ; Seubert, Andreas ; Klingl, Andreas ; Greenblatt, Charles L. ; Jérôme, Valérie ; Agarwal, Seema ; Freitag, Ruth ; Greiner, Andreas:
Living Composites of Bacteria and Polymers as Biomimetic Films for Metal Sequestration and Bioremediation.
In: Macromolecular Bioscience. Vol. 15 (2015) Issue 8 . - pp. 1052-1059.
DOI: https://doi.org/10.1002/mabi.201400538

Duan, Gaigai ; Jiang, Shaohua ; Jérôme, Valérie ; Wendorff, Joachim H. ; Fathi, Amir ; Uhm, Jacqueline S. ; Altstädt, Volker ; Herling, Markus M. ; Breu, Josef ; Freitag, Ruth ; Agarwal, Seema ; Greiner, Andreas:
Ultralight, Soft Polymer Sponges by Self-Assembly of Short Electrospun Fibers in Colloidal Dispersions.
In: Advanced Functional Materials. Vol. 25 (2015) Issue 19 . - pp. 2850-2856.
DOI: https://doi.org/10.1002/adfm.201500001

2014

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Kaiser, Patrick ; Werner, Melanie ; Jérôme, Valérie ; Hübner, Holger ; Buchholz, Rainer ; Freitag, Ruth:
Cell Retention by Encapsulation for the Cultivation of Jurkat Cells in Fixed and Fluidized Bed Reactors.
In: Biotechnology and Bioengineering. Vol. 111 (December 2014) Issue 12 . - pp. 2571-2579.
DOI: https://doi.org/10.1002/bit.25304

Schubert, Sven:
Charakterisierung der mischmodalen Interaktion von Antikörpern mit Apatitphasen.
Berlin : Köster , 2014 . - XVII, 193 p. - (Wissenschaftliche Schriftenreihe Bioprozesstechnik ; 5 )
( Doctoral thesis, 2013 , Universität Bayreuth, Fakultät für Ingenieurwissenschaften)

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Freitag, Ruth:
Chromatographic techniques in the downstream processing of proteins in biotechnology.
In: Pörtner, Ralf (ed.): Animal cell biotechnology : methods and protocols. - New York, NY : Humana Press, 2014 . - pp. 419-458 . - (Methods in Molecular Biology ; 1104 )
DOI: https://doi.org/10.1007/978-1-62703-733-4_25

2013

Werner, Melanie:
Charakterisierung von Polyelektrolytkapseln hinsichtlich materialtechnischer und zellbiologischer Eigenschaften und Anwendung dieser für die Analyse der Mikroumgebung verkapselter T-Lymphozyten.
Berlin : Köster , 2013 . - X, 110, L p. - (Wissenschaftliche Schriftenreihe Bioprozesstechnik ; 4 )
( Doctoral thesis, 2013 , Universität Bayreuth, Fakultät für Ingenieurwissenschaften)

Majewski, Alexander P. ; Stahlschmidt, Ullrich ; Jérôme, Valérie ; Freitag, Ruth ; Müller, Axel H. E. ; Schmalz, Holger:
PDMAEMA-Grafted Core-Shell-Corona Particles for Nonviral Gene Delivery and Magnetic Cell Separation.
In: Biomacromolecules. Vol. 14 (2013) Issue 9 . - pp. 3081-3090.
DOI: https://doi.org/10.1021/bm400703d

Werner, Melanie ; Biss, Karsten ; Jérôme, Valérie ; Hilbrig, Frank ; Freitag, Ruth ; Zambrano, Kenny ; Hübner, Holger ; Buchholz, Rainer ; Mahou, Redouan ; Wandrey, Christine:
Use of the mitochondria toxicity assay for quantifying the viable cell density of microencapsulated Jurkat cells.
Universität Bayreuth - LS Bioprozesstechnik
In: Biotechnology Progress. Vol. 29 (2013) Issue 4 . - pp. 986-993.
DOI: https://doi.org/10.1002/btpr.1734

2012

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Freimark, Denise ; Jérôme, Valérie ; Freitag, Ruth:
Effect of process parameters and product-host-interaction on hVEGFA-production by recombinant Chinese hamster ovary cells.
In: Biotechnology Progress. Vol. 28 (May 2012) Issue 3 . - pp. 762-772.
DOI: https://doi.org/10.1002/btpr.1524

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Hilbrig, Frank ; Freitag, Ruth:
Isolation and purification of recombinant proteins, antibodies and plasmid DNA with hydroxyapatite chromatography.
In: Biotechnology Journal. Vol. 7 (January 2012) Issue 1 . - pp. 90-102.
DOI: https://doi.org/10.1002/biot.201100015

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Majewski, Alexander P. ; Schallon, Anja ; Jérôme, Valérie ; Freitag, Ruth ; Müller, Axel H. E. ; Schmalz, Holger:
Dual-Responsive Magnetic Core–Shell Nanoparticles for Nonviral Gene Delivery and Cell Separation.
In: Biomacromolecules. Vol. 13 (2012) Issue 3 . - pp. 857-866.
DOI: https://doi.org/10.1021/bm2017756

Kurz, Katrin:
Isolierung und Charakterisierung proteinogener BPTI-Liganden und deren Potential zur nachträglichen chemischen Modifikation.
Berlin : Köster , 2012 . - XI, 124 p. - (Wissenschaftliche Schriftenreihe Bioprozesstechnik ; Bd. 2 )
( Doctoral thesis, 2012 , Universität Bayreuth, Fakultät für Ingenieurwissenschaften)

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Schallon, Anja ; Synatschke, Christopher V. ; Jérôme, Valérie ; Müller, Axel H. E. ; Freitag, Ruth:
Nanoparticulate Nonviral Agent for the Effective Delivery of pDNA and siRNA to Differentiated Cells and Primary Human T Lymphocytes.
In: Biomacromolecules. Vol. 13 (2012) Issue 11 . - pp. 3463-3474.
DOI: https://doi.org/10.1021/bm3012055

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Freitag, Ruth ; Jérôme, Valérie ; Müller, Axel H. E. ; Schmalz, Holger:
Polymermodifizierte magnetische Nanopartikel.
In: GIT : Labor-Fachzeitschrift. (2012) Issue 8 . - p. 602.

Schallon, Anja:
Untersuchung des nicht-viralen Gentransfers mit den Polymeren PEI und PDMAEMA.
Berlin : Köster , 2012 . - III, 162 p. - (Wissenschaftliche Schriftenreihe Bioprozesstechnik ; 3 )
( Doctoral thesis, 2012 , Universität Bayreuth, Fakultät für Ingenieurwissenschaften)

2011

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Arnold, Marc ; Bittermann, Holger ; Kalbfuss-Zimmermann, Bernd ; Neumann, Thomas ; Schmidt, Kristina ; Sekul, Renate ; Hilbrig, Frank ; Ludolph, Heiko ; Freitag, Ruth:
Antibody purification by affinity chromatography based on small molecule affinity ligands identified by SPR-based screening of chemical microarrays.
In: Journal of Chromatography A. Vol. 1218 (July 2011) Issue 29 . - 4649 - 4659.
DOI: https://doi.org/10.1016/j.chroma.2011.05.040

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Schallon, Anja ; Synatschke, Christopher V. ; Pergushov, Dmitry V. ; Jérôme, Valérie ; Müller, Axel H. E. ; Freitag, Ruth:
DNA Melting Temperature Assay for Assessing the Stability of DNA Polyplexes Intended for Nonviral Gene Delivery.
In: Langmuir. Vol. 27 (2011) Issue 19 . - pp. 12042-12051.
DOI: https://doi.org/10.1021/la201803c

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Synatschke, Christopher V. ; Schallon, Anja ; Jérôme, Valérie ; Freitag, Ruth ; Müller, Axel H. E.:
Influence of Polymer Architecture and Molecular Weight of Poly(2-(dimethylamino)ethyl methacrylate) Polycations on Transfection Efficiency and Cell Viability in Gene Delivery.
In: Biomacromolecules. Vol. 12 (2011) Issue 12 . - pp. 4247-4255.
DOI: https://doi.org/10.1021/bm201111d

Pfaff, André ; Schallon, Anja ; Ruhland, Thomas M. ; Majewski, Alexander P. ; Schmalz, Holger ; Freitag, Ruth ; Müller, Axel H. E.:
Magnetic and Fluorescent Glycopolymer Hybrid Nanoparticles for Intranuclear Optical Imaging.
In: Biomacromolecules. Vol. 12 (2011) Issue 10 . - pp. 3805-3811.
DOI: https://doi.org/10.1021/bm201051p

2010

Jung, Christoph ; Polier, Sigrun ; Schoeffel, Markus ; Drechsler, Markus ; Jérôme, Valérie ; Freitag, Ruth:
Fluorescence Correlation Spectroscopy as a Quantitative Tool Applied to Drug Delivery Model Systems.
In: Nature Precedings. (January 2010) .
DOI: https://doi.org/10.1038/npre.2010.4140.1

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Freimark, Denise ; Jérôme, Valérie ; Freitag, Ruth:
A GFP-based method facilitates clonal selection of transfected CHO cells.
In: Biotechnology Journal. Vol. 5 (January 2010) Issue 1 . - pp. 24-31.
DOI: https://doi.org/10.1002/biot.200800264

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Müllner, Markus ; Schallon, Anja ; Walther, Andreas ; Freitag, Ruth ; Müller, Axel H. E.:
Clickable, Biocompatible, and Fluorescent Hybrid Nanoparticles for Intracellular Delivery and Optical Imaging.
In: Biomacromolecules. Vol. 11 (2010) Issue 2 . - pp. 390-396.
DOI: https://doi.org/10.1021/bm901099p

2009

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Jérôme, Valérie ; Heider, Andreas ; Schallon, Anja ; Freitag, Ruth:
Exhaustive in vivo labelling of plasmid DNA with BrdU for intracellular detection in non-viral transfection of mammalian cells.
In: Biotechnology Journal. Vol. 4 (October 2009) Issue 10 . - pp. 1479-1487.
DOI: https://doi.org/10.1002/biot.200900053

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Parisot, Judicaël ; Kurz, Katrin ; Hilbrig, Frank ; Freitag, Ruth:
Use of azobenzene amino acids as photo-responsive conformational switches to regulate antibody–antigen interaction.
In: Journal of Separation Science. Vol. 32 (May 2009) Issue 10 . - pp. 1613-1624.
DOI: https://doi.org/10.1002/jssc.200800698

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Hilbrig, Frank ; Jérôme, Valérie ; Salzig, Mark ; Freitag, Ruth:
Strategy for the isolation of native dehydrogenases with potential for biosensor development from the organism Hyphomicrobium zavarzinii ZV580.
In: Journal of Chromatography A. Vol. 1216 (April 2009) Issue 16 . - 3518 - 3525.
DOI: https://doi.org/10.1016/j.chroma.2008.09.020

Hofstetter, Eugen-Maria ; Gabler, Ralf ; Peiffer, Stefan ; Hilbrig, Frank ; Freitag, Ruth:
Ammoniakstrippung an einer etablierten, thermophilen Biogasanlage - technische und wirtschaftliche Evaluierung.
In: Chemie Ingenieur Technik. Vol. 81 (2009) Issue 7 . - pp. 921-932.
DOI: https://doi.org/10.1002/cite.200900033

Weiss, Agnes ; Jérôme, Valérie ; Burghardt, Diana ; Likke, Likke ; Peiffer, Stefan ; Hofstetter, Eugen-Maria ; Gabler, Ralf ; Freitag, Ruth:
Investigation of factors influencing biogas production in a large-scale thermophilic municipal biogas plant.
In: Applied Microbiology and Biotechnology. Vol. 84 (2009) Issue 5 . - pp. 987-1001.
DOI: https://doi.org/10.1007/s00253-009-2093-6

2008

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Weiss, Agnes ; Jérôme, Valérie ; Freitag, Ruth ; Mayer, Helmut K.:
Diversity of the resident microbiota in a thermophilic municipal biogas plant.
In: Applied Microbiology and Biotechnology. Vol. 81 (November 2008) Issue 1 . - pp. 163-173.
DOI: https://doi.org/10.1007/s00253-008-1717-6

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Stocker, Gisela ; Dumoulin, Dorothée ; Vandevyver, Caroline ; Hilbrig, Frank ; Freitag, Ruth:
Screening of a human antibody phage display library against a peptide antigen using stimuli-responsive bioconjugates.
In: Biotechnology Progress. Vol. 24 (November 2008) Issue 6 . - pp. 1314-1324.
DOI: https://doi.org/10.1002/btpr.60

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Stocker-Majd, Gisela ; Hilbrig, Frank ; Freitag, Ruth:
Extraction of haemoglobin from human blood by affinity precipitation using a haptoglobin-based stimuli–responsive affinity macroligand.
In: Journal of Chromatography A. Vol. 1194 (June 2008) Issue 1 . - 57 - 65.
DOI: https://doi.org/10.1016/j.chroma.2008.03.091

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Achmann, Sabine ; Hermann, Markus ; Hilbrig, Frank ; Jérôme, Valérie ; Hämmerle, Martin ; Freitag, Ruth ; Moos, Ralf:
Direct detection of formaldehyde in air by a Novel NAD⁺- and glutathione-independent formaldehyde dehydrogenase-Based biosensor.
In: Talanta. Vol. 75 (15 May 2008) Issue 3 . - pp. 786-791.
DOI: https://doi.org/10.1016/j.talanta.2007.12.015

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Jérôme, Valérie ; Hermann, Markus ; Hilbrig, Frank:
A fast method for the quantification of methylamine in fermentation broths by gas chromatography.
In: Journal of Chromatography B. Vol. 861 (January 2008) Issue 1 . - pp. 88-94.
DOI: https://doi.org/10.1016/j.jchromb.2007.11.027

Freimark, Denise:
Entwicklung und Charakterisierung von Bioprozessen zur Produktion osteoinduktiver Wachstumsfaktoren in Chinese-Hamster-ovary-Zellen.
Berlin : Köster , 2008 . - XII, 241 p. - (Wissenschaftliche Schriftenreihe Bioprozesstechnik ; 1 )
( Doctoral thesis, 2008, Universität Bayreuth, Fakultät für Ingenieurwissenschaften)

Freitag, Ruth ; Hilbrig, Frank:
Use of the avidin (imino)biotin system as a general approach to affinity precipitation.
In: McMahon, Robert J. (ed.): Avidin-Biotin interactions : methods and applications. - Totowa, NJ : Humana Press, 2008 . - pp. 35-50 . - (Methods in Molecular Biology ; 418 )

2007

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Jérôme, Valérie ; Hermann, Markus ; Hilbrig, Frank ; Freitag, Ruth:
Development of a fed-batch process for the production of a dye-linked formaldehyde dehydrogenase in Hyphomicrobium zavarzinii ZV 580.
In: Applied Microbiology and Biotechnology. Vol. 77 (December 2007) Issue 4 . - pp. 779-788.
DOI: https://doi.org/10.1007/s00253-007-1218-z

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Vandevyver, Caroline ; Canarelli, Stéphane ; Bossen, Claudia ; Fisch, Igor ; Motmans, Kris ; Raus, Jef ; Freitag, Ruth:
Investigation and molecular mimicry of the antigen involved in the interaction between the monoclonal antibody 5D10 and the human breast cancer cell line MCF-7.
In: Biotechnology and Bioengineering. Vol. 97 (July 2007) Issue 4 . - pp. 721-734.
DOI: https://doi.org/10.1002/bit.21276

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Freitag, Ruth ; Schumacher, Ivo ; Hilbrig, Frank:
Affinity precipitation an option for early capture in bioprocessing.
In: Biotechnology Journal. Vol. 2 (June 2007) Issue 6 . - pp. 685-690.
DOI: https://doi.org/10.1002/biot.200600200

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Weiss, Agnes ; Jérôme, Valérie ; Freitag, Ruth:
Comparison of strategies for the isolation of PCR-compatible, genomic DNA from a municipal biogas plants.
In: Journal of Chromatography B. Vol. 853 (June 2007) Issue 1/2 . - 190 - 197.
DOI: https://doi.org/10.1016/j.jchromb.2007.03.009

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Willert-Porada, Monika ; Lorenz, Katrin ; Freitag, Ruth ; Jérôme, Valérie ; Pfeiffer, Stefan:
Biofilm Based Microbial Fuel Cell.
In: Laudon, Matthew ; Romanowicz, Bart (ed.): NSTI Nanotech 2007. - Boston Mass. : Nano Science and Technology Institute, 2007 . - pp. 728-731

O'Mahony, Kevin ; Freitag, Ruth ; Hilbrig, Frank ; Schumacher, Ingo ; Müller, Patrick:
Integration of bacteria capture via filtration and in situ lysis for recovery of plasmid DNA under industry-compatible conditions.
In: Biotechnology Progress. Vol. 23 (2007) Issue 4 . - pp. 895-903.
DOI: https://doi.org/10.1021/bp0701113

Achmann, Sabine ; Hermann, Markus ; Jérôme, Valérie ; Hämmerle, Martin ; Freitag, Ruth ; Moos, Ralf:
NAD-unabhängige Formaldehyddehydrogenase aus H. zavarzinii : Einsatz im Biosensor.
2007
Event: 5. Deutsches Biosensor Symposium 2007 , 18.-21.03.2007 , Bochum, Deutschland.
(Conference item: Conference , Other Presentation type)

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2006

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Jérôme, Valérie ; Graser, Andreas ; Müller, Rolf ; Kontermann, Roland E. ; Konur, Abdo:
Cytotoxic T lymphocytes responding to low dose TRP2 antigen are induced against B16 melanoma by liposome-encapsulated TRP2 peptide and CpG DNA adjuvant.
In: Journal of Immunotherapy. Vol. 29 (May 2006) Issue 3 . - pp. 294-305.
DOI: https://doi.org/10.1097/01.cji.0000199195.97845.18

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O'Mahony, Kevin ; Freitag, Ruth ; Dhote, Bernhard ; Hilbrig, Frank ; Müller, Patrick ; Schumacher, Ivo:
Capture of Bacteria from Fermentation Broth by Body Feed Filtration : A Solved Problem?
In: Biotechnology Progress. Vol. 22 (2006) Issue 2 . - pp. 471-483.
DOI: https://doi.org/10.1021/bp050302a

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Pöhner, Claudia ; Hilbrig, Frank ; Jérôme, Valérie ; Freitag, Ruth:
Design and Characterization of Stimuli-Responsive FLAG-tag Analogues and the Illumination-Induced Modulation of Their Interaction with Antibody 4E11.
In: Biotechnology Progress. Vol. 22 (2006) Issue 4 . - pp. 1170-1178.
DOI: https://doi.org/10.1021/bp060011h

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Stocker, Gisela ; Vandevyver, Caroline ; Hilbrig, Frank ; Freitag, Ruth:
Purification of RT-PCR Competent Poly(A) mRNA from Crude Cell Lysate by Affinity Precipitation.
In: Biotechnology Progress. Vol. 22 (2006) Issue 6 . - pp. 1621-1629.
DOI: https://doi.org/10.1021/bp060095u

2005

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Desponds, Arnaud ; Freitag, Ruth:
Light-responsive bioconjugates as novel tools for specific capture of biologicals by photoaffinity precipitation.
In: Biotechnology and Bioengineering. Vol. 91 (September 2005) Issue 5 . - pp. 583-591.
DOI: https://doi.org/10.1002/bit.20479

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O'Mahony, Kevin ; Freitag, Ruth ; Hilbrig, Frank ; Müller, Patrick ; Schumacher, Ivo:
Proposal for a better integration of bacterial lysis into the production of plasmid DNA at large scale.
In: Journal of Biotechnology. Vol. 119 (September 2005) Issue 2 . - pp. 118-132.
DOI: https://doi.org/10.1016/j.jbiotec.2005.03.020

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Suarez, Mougli ; Haenni, Marisa ; Canarelli, Stéphane ; Fisch, Florian ; Chodanowski, Pierre ; Servis, Catherine ; Michielin, Olivier ; Freitag, Ruth ; Moreillon, Philippe ; Mermod, Nicolas:
Structure-Function Characterization and Optimization of a Plant-Derived Antibacterial Peptide.
In: Antimicrobial Agents and Chemotherapy. Vol. 49 (September 2005) Issue 9 . - pp. 3847-3857.
DOI: https://doi.org/10.1128/AAC.49.9.3847-3857.2005

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Jozwik, Magdalena ; Kaczmarski, Krzystof ; Freitag, Ruth:
Investigation of the steric mass action formalism in the simulation of breakthrough curves on a monolithic and a packed bed column.
In: Journal of Chromatography A. Vol. 1073 (May 2005) Issue 1/2 . - 111 - 121.
DOI: https://doi.org/10.1016/j.chroma.2005.01.059

Volltext
Yamahata, Christophe ; Vandevyver, Caroline ; Lacharme, Frederic ; Izewska, Paulina ; Vogel, Horst ; Freitag, Ruth ; Gijs, Martin A. M.:
Pumping of mammalian cells with a nozzle-diffuser micropump.
In: Lab on a Chip. Vol. 5 (2005) Issue 10 . - pp. 1083-1088.
DOI: https://doi.org/10.1039/B504468E

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2004

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Malinova, Vesela ; Freitag, Ruth ; Wandrey, Christine:
Adsorption of charged macromolecules on oppositely charged porous column materials.
In: Journal of Chromatography A. Vol. 1036 (May 2004) Issue 1 . - 25 - 32.
DOI: https://doi.org/10.1016/j.chroma.2003.10.087

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Kern, Christoph ; Jess, Andreas ; Altstädt, Volker ; Langenfelder, Dieter ; Wöllecke, Frank:
Messung der Löslichkeit und des Stofftransports von CO2 in polymeren Werkstoffen mit Hilfe einer Magnetschwebewaage.
In: Chemie Ingenieur Technik. Vol. 76 (2004) Issue 9 . - p. 1352.
DOI: https://doi.org/10.1002/cite.200490252

2003

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Gehrke, Stephan ; Jérôme, Valérie ; Müller, Rolf:
Chimeric transcriptional control units for improved liver-specific transgene expression.
In: Gene. Vol. 322 (December 2003) . - 137 - 143.
DOI: https://doi.org/10.1016/j.gene.2003.08.010

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Hilbrig, Frank ; Freitag, Ruth:
Continuous annular chromatography.
In: Journal of Chromatography B. Vol. 790 (June 2003) Issue 1/2 . - pp. 1-15.
DOI: https://doi.org/10.1016/S1570-0232(03)00085-0

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Hilbrig, Frank ; Freitag, Ruth:
Protein purification by affinity precipitation.
In: Journal of Chromatography B. Vol. 790 (June 2003) Issue 1/2 . - pp. 79-90.
DOI: https://doi.org/10.1016/S1570-0232(03)00081-3

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Costioli, Matteo D. ; Fisch, Igor ; Garret-Flaudy, Frédéric ; Hilbrig, Frank ; Freitag, Ruth:
DNA purification by triple-helix affinity precipitation.
In: Biotechnology and Bioengineering. Vol. 81 (March 2003) Issue 5 . - pp. 535-545.
DOI: https://doi.org/10.1002/bit.10497

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Kontermann, Roland E. ; Korn, Tina ; Jérôme, Valérie:
Recombinant Adenoviruses for In Vivo Expression of Antibody Fragments.
In: Welschof, Martin ; Krauss, Jürgen (ed.): Recombinant Antibodies for Cancer Therapy : Methods and Protocols. - Totowa, NJ : Humana Press, 2003 . - pp. 421-433 . - (Methods in Molecular Biology ; 207 )
DOI: https://doi.org/10.1385/1-59259-334-8:421

2002

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Canarelli, Stéphane ; Fisch, Igor ; Freitag, Ruth:
Hyphenation of multi-dimensional chromatography and mass spectrometry for the at-line-analysis of the integrity of recombinant protein drugs.
In: Journal of Chromatography B. Vol. 775 (July 2002) Issue 1 . - pp. 27-35.
DOI: https://doi.org/10.1016/S1570-0232(02)00286-6

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Giovannini, Roberto ; Freitag, Ruth:
Continuous Separation of Multicomponent Protein Mixtures by Annular Displacement Chromatography.
In: Biotechnology Progress. Vol. 18 (2002) Issue 6 . - pp. 1324-1331.
DOI: https://doi.org/10.1021/bp010154y

2001

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Nettelbeck, Dirk M. ; Miller, Daniel W. ; Jérôme, Valérie ; Zuzarte, Marylou ; Watkins, Sarah J. ; Hawkins, Robert E. ; Müller, Rolf ; Kontermann, Roland E.:
Targeting of Adenovirus to Endothelial Cells by a Bispecific Single-Chain Diabody Directed against the Adenovirus Fiber Knob Domain and Human Endoglin (CD105).
In: Molecular Therapy. Vol. 3 (June 2001) Issue 6 . - pp. 882-891.
DOI: https://doi.org/10.1006/mthe.2001.0342

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Jérôme, Valérie ; Müller, Rolf:
A synthetic leucine zipper-based dimerization system for combining multiple promoter specificities.
In: Gene Therapy. Vol. 8 (May 2001) Issue 9 . - pp. 725-729.

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Koerner, Kathrin ; Jérôme, Valérie ; Schmidt, Thorsten ; Müller, Rolf:
Cell Cycle Regulation of the Murine cdc25BPromoter: Essential Role for Nuclear Factor-Y and a Proximal Repressor Element.
In: The Journal of Biological Chemistry. Vol. 276 (March 2001) Issue 13 . - pp. 9662-9669.
DOI: https://doi.org/10.1074/jbc.M008696200

2000

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Nettelbeck, Dirk M. ; Jérôme, Valérie ; Müller, Rolf:
Gene therapy : designer promoters for tumour targeting.
In: Trends in Genetics. Vol. 16 (April 2000) Issue 4 . - 174 - 181.
DOI: https://doi.org/10.1016/S0168-9525(99)01950-2

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Garret-Flaudy, Frédéric ; Freitag, Ruth:
Use of the avidin (imino)biotin system as a general approach to affinity precipitation.
In: Biotechnology and Bioengineering. (2000) Issue 3 . - pp. 223-234.
DOI: https://doi.org/10.1002/1097-0290(2000)71:3<223::AID-BIT1012>3.0.CO;2-U

1999

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Nettelbeck, Dirk M. ; Jérôme, Valérie ; Müller, Rolf:
A dual specificity promoter system combining cell cycle-regulated and tissue-specific transcriptional control.
In: Gene Therapy. Vol. 6 (1999) Issue 7 . - pp. 1276-1281.

1998

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Jérôme, Valérie ; Müller, Rolf:
Tissue-Specific, Cell Cycle-Regulated Chimeric Transcription Factors for the Targeting of Gene Expression to Tumor Cells.
In: Human Gene Therapy. Vol. 9 (10 December 1998) Issue 18 . - pp. 2653-2659.
DOI: https://doi.org/10.1089/hum.1998.9.18-2653

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Zwicker, Jörg ; Lucibello, France C ; Jérôme, Valérie ; Brüsselbach, Sabine ; Müller, Rolf:
CDF-1 mediated repression of cell cycle genes targets a specific subset of transactivators.
In: Nucleic Acids Research. Vol. 26 (15 February 1998) Issue 4 . - pp. 4926-4932.

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Nettelbeck, Dirk M. ; Jérôme, Valérie ; Müller, Rolf:
A strategy for enhancing the transcriptional activity of weak cell type-specific promoters.
In: Gene Therapy. Vol. 5 (1998) Issue 12 . - pp. 1656-1664.

1997

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Funk, M. ; Poensgen, B. ; Graulich, W. ; Jérôme, Valérie ; Müller, Rolf:
A novel, transformation-relevant activation domain in Fos proteins.
In: Molecular and Cellular Biology. Vol. 17 (February 1997) Issue 2 . - pp. 537-544.

1993

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Jérôme, Valérie ; Vourc'h, Claire ; Baulieu, Etienne-Emile ; Catelli, Maria-Grazia:
Cell Cycle Regulation of the Chicken hsp90α Expression.
In: Experimental Cell Research. Vol. 205 (March 1993) Issue 1 . - pp. 44-51.
DOI: https://doi.org/10.1006/excr.1993.1056

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Meng, X. ; Jérôme, Valérie ; Devin, Jocelyne ; Baulieu, Etienne-Emile ; Catelli, Maria-Grazia:
Cloning of Chicken hsp90β : The Only Vertebrate hsp90 Insensitive to Heat Shock.
In: Biochemical and Biophysical Research Communications. Vol. 190 (January 1993) Issue 2 . - pp. 630-636.
DOI: https://doi.org/10.1006/bbrc.1993.1095

1991

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Jérôme, Valérie ; Léger, Josette ; Devin, Jocelyne ; Baulieu, Etienne-Emile ; Catelli, Maria-Grazia:
Growth Factors Acting Via Tyrosine Kinase Receptors Induce HSP90a Gene Expression.
In: Growth Factors. Vol. 4 (1 January 1991) Issue 4 . - pp. 317-327.
DOI: https://doi.org/10.3109/08977199109043917

1989

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Vourc'h, Claire ; Binart, N. ; Chambraud, B. ; David, J. P. ; Jérôme, Valérie ; Baulieu, Etienne-Emile ; Catelli, Maria-Grazia:
Isolation and functional analysis of chicken 90-kDa heat shock protein gene promoter.
In: Nucleic Acids Research. Vol. 17 (11 July 1989) Issue 13 . - pp. 5259-5272.

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