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Inorganic and methylated thioarsenates pass the gastrointestinal barrier

Title data

Hinrichsen, Sinikka ; Geist, Franziska ; Planer-Friedrich, Britta:
Inorganic and methylated thioarsenates pass the gastrointestinal barrier.
In: Chemical Research in Toxicology. Vol. 28 (2015) Issue 9 . - pp. 1678-1680.
ISSN 1520-5010
DOI: https://doi.org/10.1021/acs.chemrestox.5b00268

Abstract in another language

Arsenic forms different species that are toxic for humans. Toxicity to internal organs is however only relevant if the respective species passes the gastrointestinal barrier. Thioarsenates were known to be produced by gut microbiota and to be toxic to bladder and liver cells, but their intestinal transport was largely unknown. Using a Caco-2 cell model, we show here that dimethylmonothioarsenate has the highest cellular retention and intestinal transport of all methylat-ed species. Mono- and trithioarsenate show little cellular retention like arsenate, but their intestinal transport is much higher than that of arsenate; for trithioarsenate almost as high as for arsenite. The transport of all thioarsenates in-creases in the absence of phosphate. With the present study, we link previous reports of thioarsenate formation and toxicity by proving their bioavailability and confirm the relevance of their consideration in As risk assessments.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: BAYCEER130692
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Earth Sciences > Professorship Environmental Geochemistry Group
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Earth Sciences > Professorship Environmental Geochemistry Group > Professorship Environmental Geochemistry - Univ.-Prof. Dr. Britta Planer-Friedrich
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center of Ecology and Environmental Research- BayCEER
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Earth Sciences
Result of work at the UBT: Yes
DDC Subjects: 500 Science
Date Deposited: 01 Aug 2016 11:40
Last Modified: 01 Aug 2016 11:40
URI: https://eref.uni-bayreuth.de/id/eprint/33749