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Switchable Cas9

Title data

Richter, Florian ; Fonfara, Ines ; Gelfert, Renate ; Nack, Jennifer ; Charpentier, Emmanuelle ; Möglich, Andreas:
Switchable Cas9.
In: Current Opinion in Biotechnology. Vol. 48 (2017) . - pp. 119-126.
ISSN 1879-0429
DOI: https://doi.org/10.1016/j.copbio.2017.03.025

Abstract in another language

Ever since its discovery, Cas9 from Streptococcus pyogenes has revolutionized biology by enabling analysis and engineering of genomes with unprecedented precision and ease. To fine-tune on-target effects and to mitigate adverse effects caused by untimely and off-target action of Cas9, strategies have been developed to control its activity at the post-translational stage via external trigger signals. Control is either achieved by modifying the Cas9 protein itself or its programmable RNA molecules. To date, switchable Cas9 variants responding to small ligands, light or temperature have been engineered. With these variants in hand, the regulation and modification of genomes can be accomplished in graded and ever more precise manner.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Andreas Möglich
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 570 Life sciences, biology
Date Deposited: 03 May 2017 08:37
Last Modified: 03 May 2017 08:37
URI: https://eref.uni-bayreuth.de/id/eprint/36918