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Monitoring recovery from iron deficiency using total hemoglobin mass

Title data

Wachsmuth, Nadine ; Aigner, Thomas ; Völzke, Christian ; Zapf, Jürgen ; Schmidt, Walter:
Monitoring recovery from iron deficiency using total hemoglobin mass.
In: Medicine & Science in Sports & Exercise. Vol. 47 (February 2015) Issue 2 . - pp. 419-427.
ISSN 1530-0315
DOI: https://doi.org/10.1249/MSS.0000000000000420

Abstract in another language

INTRODUCTION
Using hemoglobin concentration ([Hb]) to diagnose borderline iron deficiency and monitor the progress of its treatment is difficult because of the confounding effects of plasma volume. Because hemoglobin mass (Hbmass) is not affected by plasma volume, it may be a more sensitive parameter. The aim of this study was to monitor Hbmass, iron storage, and maximal oxygen consumption (V˙O2max) during and after oral iron therapy in subjects with severe and moderate iron deficiency.

METHODS
Three groups of female recreational athletes were monitored for at least 22 wk, as follows: 1) severe iron deficiency group (SID) (n = 8; ferritin, ≤12 ng·mL), 2) moderate iron deficiency group (MID) (n = 14; ferritin, ≤25 ng·mL), and 3) control group (n = 8; ferritin, >25 ng·mL). Hbmass and iron status were determined before, during, and up to 12 wk after at least 10 wk of oral iron supplementation. In total, five V˙O2max tests were performed before, during, and after the supplementation period.

RESULTS
Hbmass increased markedly in the SID group (15.6% ± 11.0%, P < 0.001) and slightly in the MID group (2.2% ± 3.7%, P < 0.05) by the end of the supplementation period and remained at this level for the following 12 wk. [Hb] and Hbmass were similarly affected, but Hbmass was more closely related to mean corpuscular volume and mean corpuscular hemoglobin than [Hb]. The SID group incorporated 534 ± 127 mg of iron into ferritin and hemoglobin, whereas the MID group incorporated 282 ± 68 mg of iron. V˙O2max increased only in the SID group by 0.20 ± 0.18 L·min (P < 0.05) and was closely related to Hbmass (P < 0.01).

CONCLUSIONS
Hbmass is a sensitive tool for monitoring recovery from iron deficiency anemia and assessing the effectiveness of iron supplementation in individuals with severe or moderate iron deficiency.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Cultural Studies > Department of Sport Science
Faculties > Faculty of Cultural Studies > Department of Sport Science > Professorship Sports Science IV > Professorship Sports Science IV - Univ.-Prof. Dr. Walter Schmidt
Faculties
Faculties > Faculty of Cultural Studies
Faculties > Faculty of Cultural Studies > Department of Sport Science > Professorship Sports Science IV
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 610 Medicine and health
Date Deposited: 07 Sep 2017 08:11
Last Modified: 07 Sep 2017 08:19
URI: https://eref.uni-bayreuth.de/id/eprint/39211