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Monitoring recovery from iron deficiency using total hemoglobin mass

Titelangaben

Wachsmuth, Nadine ; Aigner, Thomas ; Völzke, Christian ; Zapf, Jürgen ; Schmidt, Walter:
Monitoring recovery from iron deficiency using total hemoglobin mass.
In: Medicine & Science in Sports & Exercise. Bd. 47 (Februar 2015) Heft 2 . - S. 419-427.
ISSN 1530-0315
DOI: 10.1249/MSS.0000000000000420

Abstract

INTRODUCTION
Using hemoglobin concentration ([Hb]) to diagnose borderline iron deficiency and monitor the progress of its treatment is difficult because of the confounding effects of plasma volume. Because hemoglobin mass (Hbmass) is not affected by plasma volume, it may be a more sensitive parameter. The aim of this study was to monitor Hbmass, iron storage, and maximal oxygen consumption (V˙O2max) during and after oral iron therapy in subjects with severe and moderate iron deficiency.

METHODS
Three groups of female recreational athletes were monitored for at least 22 wk, as follows: 1) severe iron deficiency group (SID) (n = 8; ferritin, ≤12 ng·mL), 2) moderate iron deficiency group (MID) (n = 14; ferritin, ≤25 ng·mL), and 3) control group (n = 8; ferritin, >25 ng·mL). Hbmass and iron status were determined before, during, and up to 12 wk after at least 10 wk of oral iron supplementation. In total, five V˙O2max tests were performed before, during, and after the supplementation period.

RESULTS
Hbmass increased markedly in the SID group (15.6% ± 11.0%, P < 0.001) and slightly in the MID group (2.2% ± 3.7%, P < 0.05) by the end of the supplementation period and remained at this level for the following 12 wk. [Hb] and Hbmass were similarly affected, but Hbmass was more closely related to mean corpuscular volume and mean corpuscular hemoglobin than [Hb]. The SID group incorporated 534 ± 127 mg of iron into ferritin and hemoglobin, whereas the MID group incorporated 282 ± 68 mg of iron. V˙O2max increased only in the SID group by 0.20 ± 0.18 L·min (P < 0.05) and was closely related to Hbmass (P < 0.01).

CONCLUSIONS
Hbmass is a sensitive tool for monitoring recovery from iron deficiency anemia and assessing the effectiveness of iron supplementation in individuals with severe or moderate iron deficiency.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Institutionen der Universität: Fakultäten > Kulturwissenschaftliche Fakultät > Institut für Sportwissenschaft
Fakultäten > Kulturwissenschaftliche Fakultät > Institut für Sportwissenschaft > Professur Sportwissenschaft IV (Sportmedizin/Sportphysiologie) > Professur Sportwissenschaft IV (Sportmedizin/Sportphysiologie) - Univ.-Prof. Dr. Walter Schmidt
Fakultäten
Fakultäten > Kulturwissenschaftliche Fakultät
Fakultäten > Kulturwissenschaftliche Fakultät > Institut für Sportwissenschaft > Professur Sportwissenschaft IV (Sportmedizin/Sportphysiologie)
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
Eingestellt am: 07 Sep 2017 08:11
Letzte Änderung: 07 Sep 2017 08:19
URI: https://eref.uni-bayreuth.de/id/eprint/39211