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Structural Studies of the Equine Infectious Anemia Virus trans-activator Protein

Title data

Willbold, Dieter ; Volkmann, Andrea ; Metzger, Armin U. ; Sticht, Heinrich ; Rosin-Arbesfeld, Rina ; Gazit, Arnona ; Yaniv, Abraham ; Frank, Rainer W. ; Rösch, Paul:
Structural Studies of the Equine Infectious Anemia Virus trans-activator Protein.
In: European Journal of Biochemistry. Vol. 240 (August 1996) Issue 1 . - pp. 45-52.
ISSN 1432-1033
DOI: https://doi.org/10.1111/j.1432-1033.1996.0045h.x

Abstract in another language

Trans-activator (tat) proteins are necessary components for the completion of the T replication cycle of lentiviruses. The three-dimensional structure of the equine infectious anemia virus (EIAV) tat protein (e-tat) was studied with CD spectroscopy, NMR spectroscopy, and restrained molecular-dynamics calculations. No stable elements of regular secondary structure were detected, but the sequence regions responsible for nucleic acid binding showed helix-forming tendency, e-tat exhibits a flexible tertiary structure, and only the amino acids comprising the core sequence region form a well-defined tertiary fold. The three-dimensional structure allows discussion of biochemical data as well as data from molecular biological investigations of lentiviral tat proteins.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biopolymers
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Biopolymers - Univ.-Prof. Dr. Paul Rösch
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biopolymers > Lehrstuhl Biopolymere - Apl. Prof. Dr. Birgitta Wöhrl
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 11 Jan 2019 08:24
Last Modified: 13 Jun 2019 08:38
URI: https://eref.uni-bayreuth.de/id/eprint/46885