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Two Structurally Independent Domains of E. coli NusG Create Regulatory Plasticity via Distinct Interactions with RNA Polymerase and Regulators

Title data

Mooney, Rachel A. ; Schweimer, Kristian ; Rösch, Paul ; Gottesman, Max E. ; Landick, Robert:
Two Structurally Independent Domains of E. coli NusG Create Regulatory Plasticity via Distinct Interactions with RNA Polymerase and Regulators.
In: Journal of Molecular Biology. Vol. 391 (2009) Issue 2 . - pp. 341-358.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2009.05.078

Official URL: Volltext

Abstract in another language

NusG is a conserved regulatory protein that interacts with elongation complexes (ECs) of RNA polymerase, DNA, and RNA to modulate transcription in multiple and sometimes opposite ways. In Escherichia coli, NusG suppresses pausing and increases elongation rate, enhances termination by E. coli ρ and phage HK022 Nun protein, and promotes antitermination by λN and in ribosomal RNA operons. We report NMR studies that suggest that E. coli NusG consists of two largely independent N-and C-terminal structural domains

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: NusG; RNA polymerase (RNAP); transcription regulation
Institutions of the University: Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biopolymers
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Biopolymers - Univ.-Prof. Dr. Paul Rösch
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biopolymers > Lehrstuhl Biopolymere - Apl. Prof. Dr. Birgitta Wöhrl
Result of work at the UBT: Yes
DDC Subjects: 500 Science
500 Science > 500 Natural sciences
500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 19 Dec 2014 09:56
Last Modified: 11 Jun 2019 09:11
URI: https://eref.uni-bayreuth.de/id/eprint/5093