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Copper(II) complexes with tridentate Schiff base-like ligands : solid state and solution structures and anticancer activity

Titelangaben

Dankhoff, Katja ; Gold, Madeleine ; Kober, Luisa ; Schmitt, Florian ; Pfeifer, Lena ; Dürrmann, Andreas ; Kostrhunova, Hana ; Rothemund, Matthias ; Brabec, Viktor ; Schobert, Rainer ; Weber, Birgit:
Copper(II) complexes with tridentate Schiff base-like ligands : solid state and solution structures and anticancer activity.
In: Dalton Transactions. Bd. 48 (2019) Heft 40 . - S. 15220-15230.
ISSN 1477-9234
DOI: https://doi.org/10.1039/C9DT02571E

Abstract

We report 15 new Cu(II) complexes with tridentate NNO -acylenamino ligands derived from 2-picolylamine and bearing up to three alkyl, alkoxy, alkoxycarbonyl, or (pseudo)halide substituents. The structures of nine complexes were elucidated by single crystal X-ray diffraction analysis. Complexes with an unsubstituted pyridine ring crystallised with a square pyramidal coordination sphere, whereas substitution of the pyridine ring led to a square planar coordination sphere around the metal centre. The solution structures and properties of the complexes were characterised by UV-Vis spectroscopy and cyclic voltammetry. They were also tested for their cytotoxic effect on four human cancer cell lines. Two complexes were identified that were highly active with single-digit IC50 values, exceeding those of cisplatin by far. A tentative structure-activity relationship was proposed as well as topoisomerase I inhibition as a possible mode of action, while any significant interference with DNA and the level of reactive oxygen species could be excluded.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Professur Anorganische Chemie IV > Professur Anorganische Chemie IV - Univ.-Prof. Dr. Birgit Weber
Fakultäten
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Professur Anorganische Chemie IV
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
Eingestellt am: 19 Sep 2019 07:20
Letzte Änderung: 25 Apr 2022 09:21
URI: https://eref.uni-bayreuth.de/id/eprint/52331