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Copper(II) complexes with tridentate Schiff base-like ligands : solid state and solution structures and anticancer activity

Title data

Dankhoff, Katja ; Gold, Madeleine ; Kober, Luisa ; Schmitt, Florian ; Pfeifer, Lena ; Dürrmann, Andreas ; Kostrhunova, Hana ; Rothemund, Matthias ; Brabec, Viktor ; Schobert, Rainer ; Weber, Birgit:
Copper(II) complexes with tridentate Schiff base-like ligands : solid state and solution structures and anticancer activity.
In: Dalton Transactions. (September 2019) .
ISSN 1477-9234
DOI: https://doi.org/10.1039/C9DT02571E

Abstract in another language

We report 15 new Cu(II) complexes with tridentate NNO -acylenamino ligands derived from 2-picolylamine and bearing up to three alkyl, alkoxy, alkoxycarbonyl, or (pseudo)halide substituents. The structures of nine complexes were elucidated by single crystal X-ray diffraction analysis. Complexes with an unsubstituted pyridine ring crystallised with a square pyramidal coordination sphere, whereas substitution of the pyridine ring led to a square planar coordination sphere around the metal centre. The solution structures and properties of the complexes were characterised by UV-Vis spectroscopy and cyclic voltammetry. They were also tested for their cytotoxic effect on four human cancer cell lines. Two complexes were identified that were highly active with single-digit IC50 values, exceeding those of cisplatin by far. A tentative structure-activity relationship was proposed as well as topoisomerase I inhibition as a possible mode of action, while any significant interference with DNA and the level of reactive oxygen species could be excluded.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Anorganic Chemistry IV > Chair Anorganic Chemistry IV - Univ.-Prof. Dr. Birgit Weber
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 19 Sep 2019 07:20
Last Modified: 19 Sep 2019 07:20
URI: https://eref.uni-bayreuth.de/id/eprint/52331