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Dankhoff, Katja ; Gold, Madeleine ; Kober, Luisa ; Schmitt, Florian ; Pfeifer, Lena ; Dürrmann, Andreas ; Kostrhunova, Hana ; Rothemund, Matthias ; Brabec, Viktor ; Schobert, Rainer ; Weber, Birgit:
Copper(II) complexes with tridentate Schiff base-like ligands : solid state and solution structures and anticancer activity.
In: Dalton Transactions.
Bd. 48
(2019)
Heft 40
.
- S. 15220-15230.
ISSN 1477-9234
DOI: https://doi.org/10.1039/C9DT02571E
Abstract
We report 15 new Cu(II) complexes with tridentate NNO -acylenamino ligands derived from 2-picolylamine and bearing up to three alkyl, alkoxy, alkoxycarbonyl, or (pseudo)halide substituents. The structures of nine complexes were elucidated by single crystal X-ray diffraction analysis. Complexes with an unsubstituted pyridine ring crystallised with a square pyramidal coordination sphere, whereas substitution of the pyridine ring led to a square planar coordination sphere around the metal centre. The solution structures and properties of the complexes were characterised by UV-Vis spectroscopy and cyclic voltammetry. They were also tested for their cytotoxic effect on four human cancer cell lines. Two complexes were identified that were highly active with single-digit IC50 values, exceeding those of cisplatin by far. A tentative structure-activity relationship was proposed as well as topoisomerase I inhibition as a possible mode of action, while any significant interference with DNA and the level of reactive oxygen species could be excluded.
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| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Professur Anorganische Chemie IV > Professur Anorganische Chemie IV - Univ.-Prof. Dr. Birgit Weber Fakultäten Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Professur Anorganische Chemie IV |
| Titel an der UBT entstanden: | Ja |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Eingestellt am: | 19 Sep 2019 07:20 |
| Letzte Änderung: | 25 Apr 2022 09:21 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/52331 |