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Designed enzymatically degradable amphiphilic conetworks by radical ring-opening polymerization

Title data

Shi, Yinfeng ; Schmalz, Holger ; Agarwal, Seema:
Designed enzymatically degradable amphiphilic conetworks by radical ring-opening polymerization.
In: Polymer Chemistry. Vol. 6 (2015) Issue 35 . - pp. 6409-6415.
ISSN 1759-9954
DOI: https://doi.org/10.1039/c5py00962f

Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

A new route for the preparation of enzymatically degradable amphiphilic conetworks (APCNs) based on unsaturated polyesters by radical ring-opening copolymerization of vinylcyclopropane (VCP) with cyclic ketene acetal (CKA) is presented in this article. In the first step, the unsaturated biodegradable polyesters with random distribution of cross-linkable double bonds and degradable ester units were prepared by radical ring-opening copolymerization of VCP and CKA such as 2-methylene-4-phenyl-1,3-dioxolane (MPDO). Very similar reactivity ratios (rVCP = 0.23 ± 0.08 and rMPDO = 0.18 ± 0.02), unimodal gel permeation chromatography (GPC) curves and 2D NMR technique (heteronuclear multiple bond correlation, HMBC) showed the formation of random copolymers with unsaturation and ester units. The unsaturated units were used for cross-linking by radical polymerization with a hydrophilic macromonomer (oligo(ethylene glycol) methacrylate, OEGMA) in a second step for the formation of enzymatically degradable amphiphilic conetworks (APCNs). Enzymatic degradability was studied using Lipase from Pseudomonas cepacia. Due to the hydrophilic (HI) and hydrophobic (HO) microphase separation, the APCNs showed swelling in both water and organic solvents with different optical properties. The method provides an interesting route for making functional biodegradable APCNs using radical chemistry in the future by choosing appropriate vinyl comonomers.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Research Institutions > Research Centres > Bayreuth Center for Colloids and Interfaces - BZKG
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 12 Dec 2019 08:28
Last Modified: 12 Dec 2019 08:28
URI: https://eref.uni-bayreuth.de/id/eprint/53564