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Genetic interactions of separase regulatory subunits reveal the diverged Drosophila Cenp-C homolog

Title data

Heeger, Sebastian ; Leismann, Oliver ; Schittenhelm, Ralf ; Schraidt, Oliver ; Heidmann, Stefan ; Lehner, Christian F.:
Genetic interactions of separase regulatory subunits reveal the diverged Drosophila Cenp-C homolog.
In: Genes & Development. Vol. 19 (September 2005) Issue 17 . - pp. 2041-2053.
ISSN 1549-5477
DOI: https://doi.org/10.1101/gad.347805

Abstract in another language

Faithful transmission of genetic information during mitotic divisions depends on bipolar attachment of sister kinetochores to the mitotic spindle and on complete resolution of sister-chromatid cohesion immediately before the metaphase-to-anaphase transition. Separase is thought to be responsible for sister-chromatid separation, but its regulation is not completely understood. Therefore, we have screened for genetic loci that modify the aberrant phenotypes caused by overexpression of the regulatory separase complex subunits Pimples/securin and Three rows in Drosophila. An interacting gene was found to encode a constitutive centromere protein. Characterization of its centromere localization domain revealed the presence of a diverged CENPC motif. While direct evidence for an involvement of this Drosophila Cenp-C homolog in separase activation at centromeres could not be obtained, in vivo imaging clearly demonstrated that it is required for normal attachment of kinetochores to the spindle.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: centromere; Cenp-A; Cenp-C; kinetochore; separase ; Sister-Chromatid Separation; Centromere Protein-C; Histone H3 Variant; Anaphase Spindle Elongation; Budding Yeast Kinetochore; Saccharomyces-Cerevisiae; Caenorhabditis-Elegans; Outer Kinetochore; Inner Kinetochore; Fission Yeast
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology > Chair Genetics
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Biology
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 570 Life sciences, biology
Date Deposited: 05 Mar 2020 11:45
Last Modified: 05 May 2020 08:43
URI: https://eref.uni-bayreuth.de/id/eprint/54474