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Heeger, Sebastian ; Leismann, Oliver ; Schittenhelm, Ralf B. ; Schraidt, Oliver ; Heidmann, Stefan ; Lehner, Christian F.:
Genetic interactions of separase regulatory subunits reveal the diverged Drosophila Cenp-C homolog.
In: Genes & Development.
Bd. 19
(2005)
Heft 17
.
- S. 2041-2053.
ISSN 1549-5477
DOI: https://doi.org/10.1101/gad.347805
Abstract
Faithful transmission of genetic information during mitotic divisions depends on bipolar attachment of sister kinetochores to the mitotic spindle and on complete resolution of sister-chromatid cohesion immediately before the metaphase-to-anaphase transition. Separase is thought to be responsible for sister-chromatid separation, but its regulation is not completely understood. Therefore, we have screened for genetic loci that modify the aberrant phenotypes caused by overexpression of the regulatory separase complex subunits Pimples/securin and Three rows in Drosophila. An interacting gene was found to encode a constitutive centromere protein. Characterization of its centromere localization domain revealed the presence of a diverged CENPC motif. While direct evidence for an involvement of this Drosophila Cenp-C homolog in separase activation at centromeres could not be obtained, in vivo imaging clearly demonstrated that it is required for normal attachment of kinetochores to the spindle.
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| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Keywords: | centromere; Cenp-A; Cenp-C; kinetochore; separase ; Sister-Chromatid Separation; Centromere Protein-C; Histone H3 Variant; Anaphase Spindle Elongation; Budding Yeast Kinetochore; Saccharomyces-Cerevisiae; Caenorhabditis-Elegans; Outer Kinetochore; Inner Kinetochore; Fission Yeast |
| Institutionen der Universität: | Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie > Lehrstuhl Genetik Fakultäten Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Biologie |
| Titel an der UBT entstanden: | Ja |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie |
| Eingestellt am: | 05 Mär 2020 11:45 |
| Letzte Änderung: | 16 Mai 2022 14:57 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/54474 |