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The ambruticins and jerangolids : chemistry, biology and chemoenzymatic synthesis of potent antifungal drug candidates

Titelangaben

Hahn, Frank ; Guth, Florian:
The ambruticins and jerangolids : chemistry, biology and chemoenzymatic synthesis of potent antifungal drug candidates.
In: Natural Product Reports. Bd. 37 (2020) Heft 10 . - S. 1300-1315.
ISSN 1460-4752
DOI: https://doi.org/10.1039/D0NP00012D

Angaben zu Projekten

Projektfinanzierung: 7. Forschungsrahmenprogramm für Forschung, technologische Entwicklung und Demonstration der Europäischen Union
Deutsche Forschungsgemeinschaft

Abstract

The ambruticins and jerangolids are myxobacterial reduced polyketides, which are produced via highly unusual biosynthetic pathways containing a plethora of non-canonical enzymatic transformations. Since the discovery of the first congeners in the late 1970s, they have been in the focus of drug development due to their good antifungal activity and low toxicity in mammals, which result from interaction with an unusual innercellular target in fungi. Despite significant efforts, which have led to the development of various total syntheses, their structural complexity has yet avoided full exploitation of their pharmacological potential. This article summarises biological, total and semisynthetic as well as biosynthetic studies on both compounds. An outlook on the biosynthesis-based approaches to them and their derivatives is presented. Due to the structural and biosynthetic characteristics of the ambruticins and jerangolids, chemoenzymatic processes that make use of their biosynthetic pathway enzymes are particularly promising to gain efficient access to derivative libraries for structure activity relationship studies.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Institutionen der Universität: Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Professur Organische Chemie - Lebensmittelchemie > Professur Organische Chemie - Lebensmittelchemie - Univ.-Prof. Dr. Frank Hahn
Profilfelder > Advanced Fields > Molekulare Biowissenschaften
Profilfelder > Emerging Fields > Lebensmittel- und Gesundheitswissenschaften
Fakultäten
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie
Fakultäten > Fakultät für Biologie, Chemie und Geowissenschaften > Fachgruppe Chemie > Professur Organische Chemie - Lebensmittelchemie
Profilfelder
Profilfelder > Advanced Fields
Profilfelder > Emerging Fields
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 500 Naturwissenschaften und Mathematik > 540 Chemie
Eingestellt am: 22 Mai 2020 06:48
Letzte Änderung: 21 Dec 2022 06:55
URI: https://eref.uni-bayreuth.de/id/eprint/55199