bei Google ScholarTitelangaben
Apsite, Indra ; Constante Ibarra, Gissela Katherine ; Dulle, Martin ; Vogt, Lena ; Caspari, Anja ; Boccaccini, Aldo R. ; Synytska, Alla ; Salehi, Sahar ; Ionov, Leonid:
4D biofabrication of fibrous artificial nerve graft for neuron regeneration.
In: Biofabrication.
Bd. 12
(2020)
Heft 3
.
- 035027.
ISSN 1758-5082
DOI: https://doi.org/10.1088/1758-5090/ab94cf
Abstract
In this paper, we describe the application of the 4D biofabrication approach for the fabrication of artificial nerve graft. Bilayer scaffolds consisting of uniaxially aligned polycaprolactonepoly(glycerol sebacate) (PCL-PGS) and randomly aligned methacrylated hyaluronic acid (HA-MA) fibers were fabricated using electrospinning and further used for the culture of PC-12 neuron cells. Tubular structures form instantly after immersion of fibrous bilayer in an aqueous buffer and the diameter of obtained tubes can be controlled by changing bilayer parameters such as the thickness of each layer, overall bilayer thickness, and medium counterion concentration. Designed scaffolds showed a self-folded scroll-like structure with high stability after four weeks of real-time degradation. The significance of this research is in the fabrication of a tuneable tubular nerve guide conduits that can simplify the current existing clinical treatment of neural injuries.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Keywords: | electrospinning; self-folding; nerve guide conduits; 4D biofabrication; neuron cells |
| Institutionen der Universität: | Fakultäten > Fakultät für Ingenieurwissenschaften > Professur Biofabrikation > Professur Biofabrikation - Univ.-Prof. Dr. Leonid Ionov Fakultäten Fakultäten > Fakultät für Ingenieurwissenschaften Fakultäten > Fakultät für Ingenieurwissenschaften > Professur Biofabrikation |
| Titel an der UBT entstanden: | Ja |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften 500 Naturwissenschaften und Mathematik > 540 Chemie 600 Technik, Medizin, angewandte Wissenschaften > 600 Technik |
| Eingestellt am: | 29 Mai 2020 07:44 |
| Letzte Änderung: | 30 Mai 2023 11:34 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/55346 |