Foamy Virus Gag p71-p68 Cleavage Is Required for Template Switch of the Reverse Transcriptase

Titelangaben

Spannaus, Ralf ; Schneider, Anna ; Hartl, Maximilian J. ; Wöhrl, Birgitta M. ; Bodem, Jochen:
Foamy Virus Gag p71-p68 Cleavage Is Required for Template Switch of the Reverse Transcriptase.
In: Journal of Virology. Bd. 87 (2013) Heft 13 . - S. 7774-7776.
ISSN 1098-5514
DOI: https://doi.org/10.1128/JVI.00833-13

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Abstract

In contrast to orthoretroviruses, processing of foamy viral p71 Gag is limited to a single cleavage site. Nevertheless, Gag maturation is essential for infectivity, but deletion of p3 results in a modest drop in infectivity. Here, we show that Gag processing of p71 to p68 and p3 is essential for full-length cDNA synthesis, while inactivation of Gag cleavage results in cDNAs containing only the RU5 region; cDNAs encompassing the U3 region were almost undetectable.