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Optoribogenetic control of regulatory RNA molecules

Title data

Pilsl, Sebastian ; Morgan, Charles ; Choukeife, Moujab ; Möglich, Andreas ; Mayer, Günter:
Optoribogenetic control of regulatory RNA molecules.
In: Nature Communications. Vol. 11 (2020) Issue 1 . - No. 4825.
ISSN 2041-1723
DOI: https://doi.org/10.1038/s41467-020-18673-5

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

Short regulatory RNA molecules underpin gene expression and govern cellular state and physiology. To establish an alternative layer of control over these processes, we generated chimeric regulatory RNAs that interact reversibly and light-dependently with the light-oxygen-voltage photoreceptor PAL. By harnessing this interaction, the function of micro RNAs (miRs) and short hairpin (sh) RNAs in mammalian cells can be regulated in a spatiotemporally precise manner. The underlying strategy is generic and can be adapted to near-arbitrary target sequences. Owing to full genetic encodability, it establishes optoribogenetic control of cell state and physiology. The method stands to facilitate the non-invasive, reversible and spatiotemporally resolved study of regulatory RNAs and protein function in cellular and organismal environments.

Further data

Item Type: Article in a journal
Refereed: Yes
Additional notes: Number: 1 Publisher: Nature Publishing Group
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Andreas Möglich
Result of work at the UBT: Yes
DDC Subjects: 500 Science > 570 Life sciences, biology
Date Deposited: 29 Sep 2020 07:14
Last Modified: 29 Sep 2020 07:14
URI: https://eref.uni-bayreuth.de/id/eprint/57732