Wrapping of Microparticles by Floppy Lipid Vesicles

Title data

Spanke, Hendrik T. ; Style, Robert W. ; François-Martin, Claire ; Feofilova, Maria ; Eisentraut, Manuel ; Kress, Holger ; Agudo-Canalejo, Jaime ; Dufresne, Eric R.:
Wrapping of Microparticles by Floppy Lipid Vesicles.
Universität Bayreuth; ETH Zürich; Max-Planck Institute for Dynamics and Self-Organization
In: Physical Review Letters. Vol. 125 (5 November 2020) Issue 19 . - No. 198102.
ISSN 1079-7114
DOI: https://doi.org/10.1103/PhysRevLett.125.198102

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Abstract in another language

Lipid membranes, the barrier defining living cells and many of their subcompartments, bind to a wide variety of nano- and micrometer sized objects. In the presence of strong adhesive forces, membranes can strongly deform and wrap the particles, an essential step in crossing the membrane for a variety of healthy and disease-related processes. A large body of theoretical and numerical work has focused on identifying the physical properties that underly wrapping. Using a model system of micron-sized colloidal particles and giant unilamellar lipid vesicles with tunable adhesive forces, we measure a wrapping phase diagram and make quantitative comparisons to theoretical models. Our data are consistent with a model of membrane-particle interactions accounting for the adhesive energy per unit area, membrane bending rigidity, particle size, and vesicle radius.