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Oncostatin M produced in Kupffer cells in response to PGE2 : possible contributor to hepatic insulin resistance and steatosis

Title data

Henkel, Janin ; Gärtner, Daniela ; Dorn, Christoph ; Hellerbrand, Claus ; Schanze, Nancy ; Elz, Sheila R. ; Püschel, Gerhard P.:
Oncostatin M produced in Kupffer cells in response to PGE2 : possible contributor to hepatic insulin resistance and steatosis.
In: Laboratory Investigation. Vol. 91 (2011) Issue 7 . - pp. 1107-1117.
ISSN 1530-0307
DOI: https://doi.org/10.1038/labinvest.2011.47

Abstract in another language

Hepatic insulin resistance is a major contributor to hyperglycemia in metabolic syndrome and type II diabetes. It is caused in part by the low-grade inflammation that accompanies both diseases, leading to elevated local and circulating levels of cytokines and cyclooxygenase products such as prostaglandin E2 (PGE2). In a recent study, PGE2 produced in Kupffer cells attenuated insulin-dependent glucose utilization by interrupting the intracellular signal chain downstream of the insulin receptor in hepatocytes. In addition to directly affecting insulin signaling in hepatocytes, PGE2 in the liver might affect insulin resistance by modulating cytokine production in non-parenchymal cells. In accordance with this hypothesis, PGE2 stimulated in the current study oncostatin M (OSM) production by Kupffer cells. OSM in turn attenuated insulin-dependent Akt-activation and, as a downstream target, glucokinase induction in hepatocytes, most likely by inducing SOCS3. In addition, it inhibited the expression of key enzymes of hepatic lipid metabolism. COX 2 and OSM mRNA were induced early in the course of the development of non-alcoholic steatohepatitis (NASH) in mice. Thus, induction of OSM production in Kupffer cells by an autocrine PGE2-dependent feed-forward loop may be an additional, thus far unrecognized, mechanism contributing to hepatic insulin resistance and the development of NASH.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties > Faculty of Life Sciences: Food, Nutrition and Health
Faculties
Result of work at the UBT: No
DDC Subjects: 500 Science > 500 Natural sciences
500 Science > 570 Life sciences, biology
Date Deposited: 26 Apr 2021 11:24
Last Modified: 26 Apr 2021 13:09
URI: https://eref.uni-bayreuth.de/id/eprint/64430