Institutions of the University of Bayreuth
Lehrstuhl Biochemie der Ernährung - Univ.-Prof. Dr. Janin Henkel-Oberländer

Huschek, Gerd ; Rawel, Harshadrai M. ; Schweikert, Torsten ; Henkel-Oberländer, Janin ; Tchewonpi Sagu, Sorel:
Characterization and optimization of microwave-assisted extraction of B-phycoerythrin from Porphyridium purpureum using response surface methodology and Doehlert design.
In: Bioresource Technology Reports. Vol. 19 (September 2022) . - 101212.
DOI: https://doi.org/10.1016/j.biteb.2022.101212

Bishop, Christopher A. ; Machate, Tina ; Henning, Thorsten ; Henkel, Janin ; Püschel, Gerhard ; Weber, Daniela ; Grune, Tilman ; Klaus, Susanne ; Weitkunat, Karolin:
Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle.
In: Nutrition & Diabetes. Vol. 12 (2022) . - 20.
DOI: https://doi.org/10.1038/s41387-022-00200-8

Püschel, Gerhard Paul ; Klauder, Julia ; Henkel, Janin:
Macrophages, Low-Grade Inflammation, Insulin Resistance and Hyperinsulinemia : A Mutual Ambiguous Relationship in the Development of Metabolic Diseases.
In: Journal of Clinical Medicine. Vol. 11 (2022) Issue 15 . - 4358.
DOI: https://doi.org/10.3390/jcm11154358

Henkel-Oberländer, Janin ; Klauder, Julia ; Statz, Meike ; Wohlenberg, Anne-Sophie ; Kuipers, Sonja ; Vahrenbrink, Madita ; Püschel, Gerhard Paul:
Enhanced Palmitate-Induced Interleukin-8 Formation in Human Macrophages by Insulin or Prostaglandin E₂.
In: Biomedicines. Vol. 9 (2021) Issue 5 . - 449.
DOI: https://doi.org/10.3390/biomedicines9050449

Klauder, Julia ; Henkel, Janin ; Vahrenbrink, Madita ; Wohlenberg, Anne-Sophie ; Camargo, Rodolfo Gonzalez ; Püschel, Gerhard Paul:
Direct and indirect modulation of LPS-induced cytokine production by insulin in human macrophages.
In: Cytokine. Vol. 136 (2020) . - 155241.
DOI: https://doi.org/10.1016/j.cyto.2020.155241

Henkel-Oberländer, Janin:
Einfluss von Prostaglandin E2 auf die Entstehung von Insulinresistenz und die Regulation der Entzündungsantwort bei der Diät-induzierten nicht-alkoholischen Fettlebererkrankung.
Universität Potsdam , 2020
( Habilitation thesis, 2021 , Universität Potsdam, Institut für Ernährungswissenschaft, Biochemie der Ernährung)

Schell, Mareike ; Chudoba, Chantal ; Leboucher, Antoine ; Alfine, Eugenia ; Flore, Tanina ; Ritter, Katrin ; Weiper, Katharina ; Wernitz, Andreas ; Henkel, Janin ; Kleinridders, André:
Interplay of Dietary Fatty Acids and Cholesterol Impacts Brain Mitochondria and Insulin Action.
In: Nutrients. Vol. 12 (2020) Issue 5 . - No. 1518.
DOI: https://doi.org/10.3390/nu12051518

Henkel, Janin ; Buchheim-Dieckow, Katja ; Castro, José P. ; Laeger, Thomas ; Wardelmann, Kristina ; Kleinridders, André ; Jöhrens, Korinna ; Püschel, Gerhard P.:
Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH.
In: Nutrients. Vol. 11 (8 November 2019) Issue 11 . - No. 2709.
DOI: https://doi.org/10.3390/nu11112709

Henkel, Janin ; Coleman, Charles Dominic ; Schraplau, Anne ; Jöhrens, Korinna ; Weiss, Thomas Siegfried ; Jonas, Wenke ; Schürmann, Annette ; Püschel, Gerhard Paul:
Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model.
In: Scientific Reports. Vol. 8 (2018) . - 16127.
DOI: https://doi.org/10.1038/s41598-018-34633-y

Püschel, Gerhard P. ; Henkel, Janin:
Dietary cholesterol does not break your heart but kills your liver.
In: Porto Biomedical Journal. Vol. 3 (2018) Issue 1 . - No. e12.
DOI: https://doi.org/10.1016/j.pbj.0000000000000012

Henkel, Janin ; Alfine, Eugenia ; Saín, Juliana ; Jöhrens, Korinna ; Weber, Daniela ; Castro, José P. ; König, Jeannette ; Stuhlmann, Christin ; Vahrenbrink, Madita ; Jonas, Wenke ; Kleinridders, André. ; Püschel, Gerhard P:
Soybean Oil-Derived Poly-Unsaturated Fatty Acids Enhance Liver Damage in NAFLD Induced by Dietary Cholesterol.
In: Nutrients. Vol. 10 (2018) Issue 9 . - No. 1326.
DOI: https://doi.org/10.3390/nu10091326

Henkel, Janin ; Coleman, Charles Dominic ; Schraplau, Anne ; Jӧhrens, Korinna ; Weber, Daniela ; Castro, José P. ; Hugo, Martin ; Schulz, Tim Julius ; Krämer, Stephanie ; Schürmann, Annette ; Püschel, Gerhard Paul:
Induction of steatohepatitis (NASH) with insulin resistance in wildtype B6 mice by a western-type diet containing soybean oil and cholesterol.
In: Molecular Medicine. Vol. 23 (2017) . - pp. 70-82.
DOI: https://doi.org/10.2119/molmed.2016.00203

Manowsky, Julia ; Camargo, Rodolfo Gonzalez ; Kipp, Anna P. ; Henkel, Janin ; Püschel, Gerhard P.:
Insulin-induced cytokine production in macrophages causes insulin resistance in hepatocytes.
In: American Journal of Physiology. Vol. 310 (2016) Issue 11 . - S. E938-E946.
DOI: https://doi.org/10.1152/ajpendo.00427.2015

Neuschäfer-Rube, Frank ; Schraplau, Anne ; Schewe, Bettina ; Lieske, Stefanie ; Krützfeldt, Julia-Mignon ; Ringel, Sebastian ; Henkel, Janin ; Birkenfeld, Andreas L. ; Püschel, Gerhard P.:
Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes.
In: Toxicology. Vol. 337 (2015) . - pp. 1-9.
DOI: https://doi.org/10.1016/j.tox.2015.08.007

Fayyaz, Susann ; Henkel, Janin ; Japtok, Lukasz ; Krämer, Stephanie ; Damm, Georg ; Seehofer, Daniel ; Püschel, Gerhard P. ; Kleuser, Burkhard:
Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P₂ receptor subtype.
In: Diabetologia. Vol. 57 (2014) Issue 2 . - pp. 373-382.
DOI: https://doi.org/10.1007/s00125-013-3123-6

Neuschäfer-Rube, Frank ; Lieske, Stefanie ; Kuna, Manuela ; Henkel, Janin ; Perry, Rachel J. ; Erion, Derek M. ; Pesta, Dominik ; Willmes, Diana M. ; Brachs, Sebastian ; von Loeffelholz, Christian ; Tolkachov, Alexander ; Schupp, Michael ; Pathe-Neuschäfer-Rube, Andrea ; Pfeiffer, Andreas F. H. ; Shulman, Gerald I. ; Püschel, Gerhard P. ; Birkenfeld, Andreas L.:
The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes.
In: Diabetes. Vol. 63 (2014) Issue 3 . - pp. 1048-1057.
DOI: https://doi.org/10.2337/db13-0749

Spruss, Astrid ; Henkel, Janin ; Kanuri, Giridhar ; Blank, Daniela ; Püschel, Gerhard P. ; Bischoff, Stephan C. ; Bergheim, Ina:
Female mice are more susceptible to nonalcoholic fatty liver disease : sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response.
In: Molecular Medicine. Vol. 18 (2012) Issue 1 . - pp. 1346-1355.
DOI: https://doi.org/10.2119/molmed.2012.00223

Henkel, Janin ; Frede, Katja ; Schanze, Nancy ; Vogel, Heike ; Schürmann, Annette ; Spruss, Astrid ; Bergheim, Ina ; Püschel, Gerhard P.:
Stimulation of fat accumulation in hepatocytes by PGE₂-dependent repression of hepatic lipolysis, β-oxidation and VLDL-synthesis.
In: Laboratory Investigation. Vol. 92 (2012) Issue 11 . - pp. 1597-1606.
DOI: https://doi.org/10.1038/labinvest.2012.128

Henkel, Janin ; Gärtner, Daniela ; Dorn, Christoph ; Hellerbrand, Claus ; Schanze, Nancy ; Elz, Sheila R. ; Püschel, Gerhard P.:
Oncostatin M produced in Kupffer cells in response to PGE2 : possible contributor to hepatic insulin resistance and steatosis.
In: Laboratory Investigation. Vol. 91 (2011) Issue 7 . - pp. 1107-1117.
DOI: https://doi.org/10.1038/labinvest.2011.47

Henkel, Janin:
Modulation der Insulin-abhängigen Regulation des hepatischen Glucose- und Lipidmetabolismus durch Prostaglandin E2.
Universität Potsdam , 2010
( Doctoral thesis, 2010, Universität Potsdam, Institut für Ernährungswissenschaft, Biochemie der Ernährung)

Henkel, Janin ; Neuschäfer-Rube, Frank ; Pathe-Neuschäfer-Rube, Andrea ; Püschel, Gerhard P.:
Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes.
In: Hepatology. Vol. 50 (2009) Issue 3 . - pp. 781-790.
DOI: https://doi.org/10.1002/hep.23064