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Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH

Title data

Henkel, Janin ; Buchheim-Dieckow, Katja ; Castro, José P. ; Laeger, Thomas ; Wardelmann, Kristina ; Kleinridders, André ; Jöhrens, Korinna ; Püschel, Gerhard P.:
Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH.
In: Nutrients. Vol. 11 (8 November 2019) Issue 11 .
ISSN 2072-6643
DOI: https://doi.org/10.3390/nu11112709

Abstract in another language

Non-alcoholic fatty liver diseases (NAFLD) including the severe form with steatohepatitis (NASH) are highly prevalent ailments to which no approved pharmacological treatment exists. Dietary intervention aiming at 10% weight reduction is efficient but fails due to low compliance. Increase in physical activity is an alternative that improved NAFLD even in the absence of weight reduction. The underlying mechanisms are unclear and cannot be studied in humans. Here, a rat NAFLD model was developed that reproduces many facets of the diet-induced NAFLD in humans. The impact of endurance exercise was studied in this model. Male Wistar rats received control chow or a NASH-inducing diet rich in fat, cholesterol, and fructose. Both diet groups were subdivided into a sedentary and an endurance exercise group. Animals receiving the NASH-inducing diet gained more body weight, got glucose intolerant and developed a liver pathology with steatosis, hepatocyte hypertrophy, inflammation and fibrosis typical of NAFLD or NASH. Contrary to expectations, endurance exercise did not improve the NASH activity score and even enhanced hepatic inflammation. However, endurance exercise attenuated the hepatic cholesterol overload and the ensuing severe oxidative stress. In addition, exercise improved glucose tolerance possibly in part by induction of hepatic FGF21 production.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: FGF21; NAFLD; NASH; cholesterol; endurance exercise; glucose intolerance; oxidative stress
Institutions of the University: Faculties > Faculty of Life Sciences: Food, Nutrition and Health
Result of work at the UBT: No
DDC Subjects: 500 Science
500 Science > 570 Life sciences, biology
Date Deposited: 26 Apr 2021 12:39
Last Modified: 26 Apr 2021 12:57
URI: https://eref.uni-bayreuth.de/id/eprint/64443